A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms

scientific article published on 16 May 2017

A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms is …
instance of (P31):
meta-analysisQ815382
scholarly articleQ13442814

External links are
P356DOI10.1194/JLR.M076232
P932PMC publication ID5580897
P698PubMed publication ID28512139

P50authorOlli RaitakariQ23039996
Peter VollenweiderQ28039313
Florian KronenbergQ28039325
Claudia LaminaQ28050004
Mika KähönenQ29839349
Terho LehtimäkiQ29839397
Gérard WaeberQ29839423
Annette PetersQ37629853
Stefan CoassinQ42643471
Ilkka SeppäläQ47157531
Sven BergmannQ55590536
Konstantin StrauchQ76510167
Rico RueediQ84253992
Steven C HuntQ89298880
P2093author name stringChristian Gieger
Thomas Meitinger
Bernhard Paulweber
Pedro Marques-Vidal
Gertraud Erhart
Lukas Forer
Sebastian Schönherr
Janina S Ried
Noha A Yousri
Ludmilla Kedenko
Andrea Stöckl
Doreen Dähnhardt
Salome Mack
KORA-Study Group
P2860cites workIdentification and analysis of functional elements in 1% of the human genome by the ENCODE pilot projectQ21061203
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Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6qQ30486850
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LPA and PLG sequence variation and kringle IV-2 copy number in two populationsQ33818108
Distribution and medical impact of loss-of-function variants in the Finnish founder populationQ33981677
Molecular basis of apolipoprotein (a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresisQ34265255
Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stressQ34346809
Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies in Adults With Hypercholesterolemia: A Systematic Review and Meta-analysisQ34473809
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Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels.Q35234069
Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrationsQ35603379
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Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetesQ35721709
The impact of low-frequency and rare variants on lipid levelsQ36591109
Sex-Specific Genetic Variants are Associated With Coronary Endothelial DysfunctionQ36877201
Inflammation stimulates the expression of PCSK9Q36945328
Associations Between Common and Rare Exonic Genetic Variants and Serum Levels of 20 Cardiovascular-Related Proteins: The Tromsø StudyQ37170991
Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohortsQ37678895
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TLR2 and TLR4 in autoimmune diseases: a comprehensive reviewQ38172423
Hyperlipoproteinemia type 3: the forgotten phenotypeQ38235600
Structure, function, and genetics of lipoprotein (a).Q38807488
Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) LevelsQ39071274
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Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European CaucasiansQ39900228
Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in manQ40108225
A novel but frequent variant in LPA KIV-2 is associated with a pronounced Lp(a) and cardiovascular risk reduction.Q40227515
Characterization of multiple enhancer regions upstream of the apolipoprotein(a) geneQ42447270
The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentrationQ42600872
Parental history and myocardial infarction risk across the world: the INTERHEART StudyQ43551638
Genetically elevated lipoprotein(a) and increased risk of myocardial infarctionQ44238417
LPA Gene, Ethnicity, and Cardiovascular EventsQ46076964
The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particlesQ46171048
A common nonsense mutation in the repetitive Kringle IV-2 domain of human apolipoprotein(a) results in a truncated protein and low plasma Lp(a).Q46221191
Lipoprotein(a) Mass Levels Increase Significantly According to APOE Genotype: An Analysis of 431 239 PatientsQ46239308
Genetic variants associated with Lp(a) lipoprotein level and coronary disease.Q50572117
Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study.Q53789135
A common LPA null allele associates with lower lipoprotein(a) levels and coronary artery disease risk.Q54203344
Frequency distributions of apolipoprotein(a) kringle IV repeat alleles and their effects on lipoprotein(a) levels in Caucasian, Asian, and African populations: the distribution of null alleles is non-randomQ57811672
To stratify or not to stratify: power considerations for population-based genome-wide association studies of quantitative traitsQ60585330
Apolipoprotein E phenotype and lipoprotein(a) in familial hypercholesterolaemia: implication for lipoprotein(a) metabolismQ72404804
Post-prandial Lp(a): identification of a triglyceride-rich particle containing apo EQ72428827
The identification of polymorphisms in the coding region of the apolipoprotein (a) gene--association with earlier identified polymorphic sites and influence on the lipoprotein (a) concentrationQ73307877
Sequence and functional changes in a putative enhancer region upstream of the apolipoprotein(a) geneQ78663526
Lipoprotein(a)-cholesterol: a significant component of serum cholesterolQ84358732
Genetic determination of lipoprotein(a) and its association with cardiovascular disease: convenient does not always mean betterQ87160159
P433issue9
P921main subjectgenome-wide association studyQ1098876
LPAQ18028636
P304page(s)1834-1844
P577publication date2017-05-16
P1433published inJournal of Lipid ResearchQ6295449
P1476titleA genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms
P478volume58

Reverse relations

cites work (P2860)
Q58566313A comprehensive map of single base polymorphisms in the hypervariable LPA Kringle IV-2 copy number variation region
Q94445741A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter
Q89934238Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis
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Q55427348Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.
Q90269588Estimation of the Required Lipoprotein(a)-Lowering Therapeutic Effect Size for Reduction in Coronary Heart Disease Outcomes: A Mendelian Randomization Analysis
Q52641914Genetic Factors Explain a Major Fraction of the 50% Lower Lipoprotein(a) Concentrations in Finns.
Q58123851Genetic Variants Associated With Plasma Lipids Are Associated With the Lipid Response to Niacin
Q87799091Impact of Apolipoprotein(a) Isoform Size on Lipoprotein(a) Lowering in the HPS2-THRIVE Study
Q47274864Lipoprotein(a) in clinical practice: New perspectives from basic and translational science
Q88497342Lipoprotein(a): the common, likely causal, yet elusive risk factor for cardiovascular disease
Q108126970Machine Learning Prediction of Biomarkers from SNPs and of Disease Risk from Biomarkers in the UK Biobank
Q52691298Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.

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