SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes.

scientific article published on March 2016

SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MOLCEL.2016.02.024
P932PMC publication ID4799497
P698PubMed publication ID26990989

P50authorMing TanQ57152427
Jung-Hyun KimQ61918827
Ssang-Taek LimQ64515245
Eun-Young AhnQ84476133
P2093author name stringGang Huang
Eun Young Park
Joshua K Stone
Richard M Myers
Erik K Flemington
Xiaomei Yan
Hyeonsoo Park
Thomas W Butler
Florencia Pauli-Behn
Melody C Baddoo
P2860cites workMenin critically links MLL proteins with LEDGF on cancer-associated target genesQ37217351
Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcriptionQ37255927
Gfi1-cells and circuits: unraveling transcriptional networks of development and diseaseQ37767120
Emerging epigenetic targets and therapies in cancer medicineQ38010385
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesisQ38015891
Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3), which promotes viability of Hodgkin/Reed-Sternberg cellsQ38319231
Targeting the MLL complex in castration-resistant prostate cancerQ38893281
New discoveries of old SON: a link between RNA splicing and cancerQ39351268
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.Q39643148
The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesisQ40359760
Let's sp(l)ice up pluripotency!Q42883138
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cellsQ43734888
Menin links estrogen receptor activation to histone H3K4 trimethylationQ83228702
Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcriptionQ22001458
SON controls cell-cycle progression by coordinated regulation of RNA splicingQ24299993
Gadd45 stress sensors in malignancy and leukemiaQ24600698
Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) proteinQ27670797
High-resolution profiling of histone methylations in the human genomeQ27860906
COMPASS: a complex of proteins associated with a trithorax-related SET domain proteinQ27931344
Organization and conservation of the GART/SON/DONSON locus in mouse and human genomesQ28144204
A cDNA clone for a novel nuclear protein with DNA binding activityQ28201469
Transcription repression of human hepatitis B virus genes by negative regulatory element-binding protein/SONQ28212953
SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 clusterQ28283462
SON connects the splicing-regulatory network with pluripotency in human embryonic stem cellsQ28298055
A chromatin landmark and transcription initiation at most promoters in human cellsQ29547180
Regulation of MLL1 H3K4 methyltransferase activity by its core componentsQ29614518
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemiaQ30425903
p21 in cancer: intricate networks and multiple activitiesQ30436015
Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.Q30537596
Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disordersQ33374851
MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.Q33694927
An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domainQ33761102
The role of SON in splicing, development, and diseaseQ34066845
WRAD: enabler of the SET1-family of H3K4 methyltransferasesQ34278347
Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexesQ34554800
Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterationsQ35025549
Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivoQ35557914
Son maintains accurate splicing for a subset of human pre-mRNAsQ35672134
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.Q35898171
Histone methylase MLL1 has critical roles in tumor growth and angiogenesis and its knockdown suppresses tumor growth in vivoQ36438203
P433issue6
P304page(s)859-873
P577publication date2016-03-01
P1433published inMolecular CellQ3319468
P1476titleSON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes
P478volume61

Reverse relations

cites work (P2860)
Q99412626A de novo heterozygous variant in the SON gene is associated with Zhu-Tokita-Takenouchi-Kim syndrome
Q38735423Alternative splicing: the pledge, the turn, and the prestige : The key role of alternative splicing in human biological systems
Q64882693Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy.
Q36174308Clustering of mRNA-Seq data based on alternative splicing patterns
Q90569904Co-inhibition of HDAC and MLL-menin interaction targets MLL-rearranged acute myeloid leukemia cells via disruption of DNA damage checkpoint and DNA repair
Q58801085DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity
Q29147448De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability Syndrome
Q64101011Differential isoform expression and alternative splicing in sex determination in mice
Q89055219Germline Stem Cell Heterogeneity Supports Homeostasis in Drosophila
Q55279675MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.
Q64949879Mapping 3D genome organization relative to nuclear compartments using TSA-Seq as a cytological ruler.
Q90038226SON haploinsufficiency causes impaired pre-mRNA splicing of CAKUT genes and heterogeneous renal phenotypes
Q103029141SON inhibits megakaryocytic differentiation via repressing RUNX1 and the megakaryocytic gene expression program in acute megakaryoblastic leukemia
Q47814736The future: genetics advances in MEN1 therapeutic approaches and management strategies.

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