The effect of empagliflozin on oxidative nucleic acid modifications in patients with type 2 diabetes: protocol for a randomised, double-blinded, placebo-controlled trial

scientific article published on 09 May 2017

The effect of empagliflozin on oxidative nucleic acid modifications in patients with type 2 diabetes: protocol for a randomised, double-blinded, placebo-controlled trial is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/BMJOPEN-2016-014728
P932PMC publication ID5623443
P698PubMed publication ID28490557

P50authorHenrik Enghusen PoulsenQ33310622
Filip K KnopQ59659637
Tina VilsbøllQ60393741
P2093author name stringJørgen Rungby
Emil List Larsen
Vanja Cejvanovic
Laura Kofoed Kjær
P2860cites workSGLT2 Inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms?Q26750510
Clinical Relevance of Biomarkers of Oxidative StressQ26785512
Common defects of mitochondria and iron in neurodegeneration and diabetes (MIND): a paradigm worth exploringQ26861082
Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitusQ28297680
Alogliptin after acute coronary syndrome in patients with type 2 diabetesQ28297690
SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trialsQ28710019
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetesQ29547541
Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of DiabetesQ34457919
The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering with oxidative stress and glucotoxicityQ34524690
Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 DiabetesQ34670462
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Long-term effects of Irbesartan treatment and smoking on nucleic acid oxidation in patients with type 2 diabetes and microalbuminuria: an Irbesartan in patients with type 2 diabetes and Microalbuminuria (IRMA 2) substudyQ35043750
Effect of empagliflozin monotherapy on postprandial glucose and 24-hour glucose variability in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled, 4-week studyQ35117192
Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patientsQ35563607
The Effects of Empagliflozin, an SGLT2 Inhibitor, on Pancreatic β-Cell Mass and Glucose Homeostasis in Type 1 DiabetesQ35903101
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Malondialdehyde as biomarker of oxidative damage to lipids caused by smoking.Q36750672
SGLT2 Inhibitors and Cardiovascular Risk: Lessons Learned From the EMPA-REG OUTCOME StudyQ36820604
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a biomarker in type 2 diabetesQ37912415
RNA modifications by oxidation: a novel disease mechanism?Q37981450
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Detection and interpretation of 8-oxodG and 8-oxoGua in urine, plasma and cerebrospinal fluidQ38116269
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Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary SyndromeQ41078909
Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass indexQ41104925
Simvastatin and oxidative stress in humans: A randomized, double-blinded, placebo-controlled clinical trialQ42725614
Survival as a function of HbA(1c) in people with type 2 diabetes: a retrospective cohort studyQ43181601
Urinary excretion of biomarkers of oxidatively damaged DNA and RNA in hereditary hemochromatosisQ43290649
Determination of malondialdehyde as dithiobarbituric acid adduct in biological samples by HPLC with fluorescence detection: comparison with ultraviolet-visible spectrophotometryQ43714076
Clarithromycin, trimethoprim, and penicillin and oxidative nucleic acid modifications in humans: randomised, controlled trialsQ46420088
Oltipraz chemoprevention trial in Qidong, People's Republic of China: Unaltered oxidative biomarkersQ61794754
P433issue5
P921main subjectplaceboQ269829
type 2 diabetesQ3025883
empagliflozinQ5373824
P304page(s)e014728
P577publication date2017-05-09
P1433published inBMJ OpenQ17003470
P1476titleThe effect of empagliflozin on oxidative nucleic acid modifications in patients with type 2 diabetes: protocol for a randomised, double-blinded, placebo-controlled trial
P478volume7