Mitochondrial transcription in mammalian cells

scientific article published on January 2017

Mitochondrial transcription in mammalian cells is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.2741/4520
P932PMC publication ID5653244
P698PubMed publication ID27814650

P2093author name stringMikhail F Alexeyev
Inna N Shokolenko
P2860cites workIdentification and characterization of mammalian mitochondrial tRNA nucleotidyltransferasesQ24291562
The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNAQ24294939
LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAsQ24295176
Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expressionQ24299068
Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNAQ24299860
Mitochondrial Atpif1 regulates haem synthesis in developing erythroblastsQ24302493
Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitroQ24307535
Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillanceQ24311728
Role of SUV3 helicase in maintaining mitochondrial homeostasis in human cellsQ24320354
Helix unwinding and base flipping enable human MTERF1 to terminate mitochondrial transcriptionQ24321529
MTERF3 is a negative regulator of mammalian mtDNA transcriptionQ24323198
RNA processing in human mitochondriaQ24324126
Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionalityQ24337635
The yeast nuclear gene suv3 affecting mitochondrial post-transcriptional processes encodes a putative ATP-dependent RNA helicaseQ37122753
The control region of mitochondrial DNA shows an unusual CpG and non-CpG methylation patternQ37383786
Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53.Q37421120
The MTERF family proteins: mitochondrial transcription regulators and beyond.Q37444322
Organization of the human mitochondrial transcription initiation complexQ37680395
A novel intermediate in transcription initiation by human mitochondrial RNA polymerase.Q37680403
Identification of a novel human nuclear-encoded mitochondrial poly(A) polymeraseQ37693914
Mechanistic insight into pentatricopeptide repeat proteins as sequence-specific RNA-binding proteins for organellar RNAs in plantsQ38009252
The role of mitochondria in cytosolic-nuclear iron–sulfur protein biogenesis and in cellular iron regulationQ38280591
The impact of mitochondrial endosymbiosis on the evolution of calcium signalingQ38284224
In organello footprint analysis of human mitochondrial DNA: human mitochondrial transcription factor A interactions at the origin of replicationQ38301808
Nuclear-encoded factors involved in post-transcriptional processing and modification of mitochondrial tRNAs in human disease.Q38389947
The amino terminal extension of mammalian mitochondrial RNA polymerase ensures promoter specific transcription initiationQ38593965
Maintenance and Expression of Mammalian Mitochondrial DNA.Q38792624
Impairment of methyl cycle affects mitochondrial methyl availability and glutathione level in Down's syndromeQ39613369
Maintenance of respiratory chain function in mouse hearts with severely impaired mtDNA transcriptionQ39861560
Polyadenylation and degradation of human mitochondrial RNA: the prokaryotic past leaves its markQ40396680
Structural models of mammalian mitochondrial transcription factor B2.Q40844000
Ribosome-associated pentatricopeptide repeat proteins function as translational activators in mitochondria of trypanosomesQ40966005
TEFM is a potent stimulator of mitochondrial transcription elongation in vitroQ41410437
The core human mitochondrial transcription initiation complex: It only takes two to tangoQ42096581
A promoter recognition mechanism common to yeast mitochondrial and phage t7 RNA polymerasesQ42125728
The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cellsQ42491908
A family of putative transcription termination factors shared amongst metazoans and plantsQ42669375
Mitochondrial biology. Replication-transcription switch in human mitochondriaQ43100171
Modeling of ATP-ADP steady-state exchange rate mediated by the adenine nucleotide translocase in isolated mitochondria.Q43254003
Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice.Q43757469
Comparative analysis of human mitochondrial methylomes shows distinct patterns of epigenetic regulation in mitochondriaQ44068476
Characterization of mature mitochondrial transcripts in Drosophila, and the implications for the tRNA punctuation model in arthropodsQ44455625
The pattern of transcription of the human mitochondrial rRNA genes reveals two overlapping transcription unitsQ45345561
Termination of transcription in human mitochondria: identification and purification of a DNA binding protein factor that promotes terminationQ45345563
Flexible recognition of rapidly evolving promoter sequences by mitochondrial transcription factor 1.Q46424856
The novel nuclear gene DSS-1 of Saccharomyces cerevisiae is necessary for mitochondrial biogenesisQ48072299
Precise identification of individual promoters for transcription of each strand of human mitochondrial DNA.Q48392139
Addition of a 29 residue carboxyl-terminal tail converts a simple HMG box-containing protein into a transcriptional activator.Q52208302
Human mitochondrial transcription factor A and promoter spacing integrity are required for transcription initiation.Q52208337
Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression.Q52533533
Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.Q52541455
The synthesis of mRNA in isolated mitochondria can be maintained for several hours and is inhibited by high levels of ATP.Q53903310
Identification of a stable RNA encoded by the H-strand of the mouse mitochondrial D-loop region and a conserved sequence motif immediately upstream of its polyadenylation siteQ58748766
The complete and symmetric transcription of the main non coding region of rat mitochondrial genome: in vivo mapping of heavy and light transcriptsQ67659199
The role of a conserved dodecamer sequence in yeast mitochondrial gene expressionQ69573507
Expression of the mitochondrial genome in HeLa cells. II. Evidence for complete transcription of mitochondrial DNAQ71769089
Expression of the mitochondria genome in HeLa cells. IV. Titration of mitochondrial genes for 16 s, 12 s and 4 s RNAQ71769092
Transcription termination at the mouse mitochondrial H-strand promoter distal site requires an A/T rich sequence motif and sequence specific DNA binding proteinsQ73112076
Termination factor-mediated DNA loop between termination and initiation sites drives mitochondrial rRNA synthesisQ82081316
Mitochondrial transcription is regulated via an ATP "sensing" mechanism that couples RNA abundance to respirationQ83294912
DNA conformation-dependent activities of human mitochondrial RNA polymeraseQ84276144
Mitochondrial epigenetics: an overlooked layer of regulation?Q87148396
TEFM (c17orf42) is necessary for transcription of human mtDNAQ24338642
Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding proteinQ24522604
The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cellsQ24559899
A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and AβQ24627359
Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expressionQ24672119
P-class pentatricopeptide repeat proteins are required for efficient 5' end formation of plant mitochondrial transcriptsQ27027070
NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assemblyQ27317049
Structure of human mitochondrial RNA polymeraseQ27674468
Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoterQ27675282
Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activationQ27681368
Sequence and organization of the human mitochondrial genomeQ27860659
DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator proteinQ27933227
Release of the yeast mitochondrial RNA polymerase specificity factor from transcription complexes.Q27935313
MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolismQ28067635
Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?Q28085240
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistanceQ28116902
Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesisQ28118716
Similarity of human mitochondrial transcription factor 1 to high mobility group proteinsQ28278034
MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulationQ28595031
Promoter selection in human mitochondria involves binding of a transcription factor to orientation-independent upstream regulatory elementsQ28611665
Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitroQ28730231
Mitochondrial DNA nucleoid structureQ29396842
CDD: NCBI's conserved domain databaseQ29615740
tRNA punctuation model of RNA processing in human mitochondriaQ29616348
Sequence and gene organization of mouse mitochondrial DNAQ29618227
Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in miceQ29619811
DNA-protein interactions in theDrosophila virilismitochondrial chromosomeQ30412389
DNA-protein interactions in the Drosophila melanogaster mitochondrial genome as deduced from trimethylpsoralen crosslinking patternsQ30463560
Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafnessQ30480487
Transient overexpression of mitochondrial transcription factor A (TFAM) is sufficient to stimulate mitochondrial DNA transcription, but not sufficient to increase mtDNA copy number in cultured cellsQ30841514
Tissue-specific mtDNA abundance from exome data and its correlation with mitochondrial transcription, mass and respiratory activityQ30872900
Genome-wide analysis reveals coating of the mitochondrial genome by TFAM.Q31134050
The 3' ends of mature transcripts are generated by a processosome complex in fission yeast mitochondriaQ33321459
TFB2 is a transient component of the catalytic site of the human mitochondrial RNA polymeraseQ33589922
Identification of multiple rate-limiting steps during the human mitochondrial transcription cycle in vitroQ33855344
Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS releaseQ33913079
Core human mitochondrial transcription apparatus is a regulated two-component system in vitro.Q33982027
Human mitochondrial mRNAs--like members of all families, similar but differentQ34102714
A different genetic code in human mitochondriaQ34280642
A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activityQ34292729
Increased mitochondrial mass in mitochondrial myopathy miceQ34381144
The human mitochondrial transcription termination factor (mTERF) is fully active in vitro in the non-phosphorylated formQ34419579
Priming of human mitochondrial DNA replication occurs at the light-strand promoterQ34563955
Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2.Q34572837
Pentatricopeptide repeat proteins stimulate mRNA adenylation/uridylation to activate mitochondrial translation in trypanosomesQ34774754
The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomesQ34887679
Human mitochondrial DNA is packaged with TFAM.Q34908739
Genetic modification of survival in tissue-specific knockout mice with mitochondrial cardiomyopathyQ35112849
Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA.Q35170688
The human mitochondrial transcriptomeQ35178219
A model for transcription initiation in human mitochondriaQ35476735
Mitochondrial ribosomal protein L12 selectively associates with human mitochondrial RNA polymerase to activate transcriptionQ35518798
Mapping of nascent light and heavy strand transcripts on the physical map of HeLa cell mitochondrial DNAQ35619833
Mitochondrial poly(A) polymerase and polyadenylationQ35840151
Transcriptional requirements of the distal heavy-strand promoter of mtDNA.Q35922066
SUV3 helicase is required for correct processing of mitochondrial transcriptsQ36002469
Mitochondrial Polyadenylation Is a One-Step Process Required for mRNA Integrity and tRNA MaturationQ36016898
Identification of initiation sites for heavy-strand and light-strand transcription in human mitochondrial DNAQ36322623
Mammalian transcription factor A is a core component of the mitochondrial transcription machineryQ36340045
Mitochondrial Ribosomal Protein L12 Is Required for POLRMT Stability and Exists as Two Forms Generated by Alternative Proteolysis during ImportQ36442466
Mitochondrial DNA damage and the aging process: facts and imaginations.Q36647425
Mitochondrial poly(A) polymerase is involved in tRNA repairQ36676486
DNA replication and transcription in mammalian mitochondriaQ36780113
Purification and characterization of human mitochondrial transcription factor 1.Q36793853
Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitroQ36837503
Precise assignment of the light-strand promoter of mouse mitochondrial DNA: a functional promoter consists of multiple upstream domainsQ36896640
Identification of primary transcriptional start sites of mouse mitochondrial DNA: accurate in vitro initiation of both heavy- and light-strand transcriptsQ36913233
Synthesis and turnover of mitochondrial ribonucleic acid in HeLa cells: the mature ribosomal and messenger ribonucleic acid species are metabolically unstableQ36968307
P304page(s)835-853
P577publication date2017-01-01
P1433published inFrontiers in BioscienceQ5506062
P1476titleMitochondrial transcription in mammalian cells
P478volume22

Reverse relations

cites work (P2860)
Q90799063MitoPlex: A targeted multiple reaction monitoring assay for quantification of a curated set of mitochondrial proteins
Q64245890Mitochondrial DNA Integrity: Role in Health and Disease
Q92122417Mitochondrial DNA: Epigenetics and environment
Q92756302Mitochondrial Transcriptome Control and Intercompartment Cross-Talk During Plant Development
Q38635442Mitochondrial-epigenetic crosstalk in environmental toxicology
Q89623383Mitoepigenetics and Its Emerging Roles in Cancer
Q89710834On separation and coding capacity of mtDNA strands
Q57281642Polynucleotide phosphorylase: Not merely an RNase but a pivotal post-transcriptional regulator

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