A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity

scientific article published on 22 January 2016

A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1541-7786.MCR-15-0361
P932PMC publication ID4794370
P698PubMed publication ID26801054

P50authorPeter DervanQ907746
P2093author name stringJerzy Szablowski
Patrick J Frost
Veena S Mysore
P2860cites workThe emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma.Q37884379
Oxygen sensing, homeostasis, and diseaseQ37914865
Synergistic induction of apoptosis in multiple myeloma cells by bortezomib and hypoxia-activated prodrug TH-302, in vivo and in vitro.Q39129256
The prolyl-hydroxylase EGLN3 and not EGLN1 is inactivated by methylation in plasma cell neoplasia.Q39802320
Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myeloma cells to melphalanQ39813872
Regulation of D-cyclin translation inhibition in myeloma cells treated with mammalian target of rapamycin inhibitors: rationale for combined treatment with extracellular signal-regulated kinase inhibitors and rapamycin.Q39896259
A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer.Q40053351
AKT activity regulates the ability of mTOR inhibitors to prevent angiogenesis and VEGF expression in multiple myeloma cellsQ40224641
Establishment of a new model of human multiple myeloma using NOD/SCID/gammac(null) (NOG) miceQ40542205
Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interfaceQ41857906
Mammalian target of rapamycin inhibitors induce tumor cell apoptosis in vivo primarily by inhibiting VEGF expression and angiogenesis.Q42141137
Solid-phase synthesis of DNA binding polyamides on oxime resinQ44022836
Enhanced sensitivity of multiple myeloma cells containing PTEN mutations to CCI-779.Q44123722
Effect of thalidomide therapy on bone marrow angiogenesis in multiple myeloma.Q44746790
Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrugQ45851460
Role of the hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression.Q46541959
A SNP microarray and FISH-based procedure to detect allelic imbalances in multiple myeloma: an integrated genomics approach reveals a wide gene dosage effectQ47934995
Hypoxia and activated VEGF/receptor pathway in multiple myelomaQ54658355
Bone marrow of patients with active multiple myeloma: angiogenesis and plasma cell adhesion molecules LFA-1, VLA-4, LAM-1, and CD44Q71709369
Prognostic value of bone marrow angiogenesis in multiple myelomaQ74216118
Results from AMBER, a randomized phase 2 study of bevacizumab and bortezomib versus bortezomib in relapsed or refractory multiple myelomaQ84587252
Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxiaQ24524140
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complexQ24559347
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxiaQ24671941
Molecular basis of the VHL hereditary cancer syndromeQ28220414
ONCOMINE: a cancer microarray database and integrated data-mining platformQ28255103
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- miceQ28588885
In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft modelQ33362103
Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells.Q33829094
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.Q33863055
A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumorQ34053649
Biological consequences of tumor hypoxiaQ34275624
Bone marrow angiogenesis and progression in multiple myeloma.Q34292940
Novel therapies targeting the myeloma cell and its bone marrow microenvironmentQ34461557
Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine modelQ34526773
A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathwaysQ35163974
Metabolic signature identifies novel targets for drug resistance in multiple myelomaQ35612105
Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosisQ35628969
Anti-VEGF/VEGFR therapy for cancer: reassessing the targetQ35910772
The updated biology of hypoxia-inducible factorQ36001994
Bone marrow microenvironment and the identification of new targets for myeloma therapyQ36162703
Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamideQ36342812
Improved survival in multiple myeloma and the impact of novel therapiesQ36478461
Hypoxia signalling in cancer and approaches to enforce tumour regressionQ36488739
Regulating cellular oxygen sensing by hydroxylation.Q36509378
Role and regulation of prolyl hydroxylase domain proteinsQ37079729
Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to folQ37106652
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonistQ37695740
Direct measurement of local oxygen concentration in the bone marrow of live animalsQ37698984
Treatment options for relapsed and refractory multiple myelomaQ37853735
P4510describes a project that usesImageJQ1659584
P433issue3
P921main subjecthypoxiaQ105688
multiple myelomaQ467635
P304page(s)253-266
P577publication date2016-01-22
P1433published inMolecular Cancer ResearchQ2751014
P1476titleA DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity
P478volume14

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cites work (P2860)
Q92508057A Novel Therapeutic Induces DEPTOR Degradation in Multiple Myeloma Cells with Resulting Tumor Cytotoxicity
Q40124517A computational protocol for the discovery of lead molecules targeting DNA unique to pathogens.
Q50043318A polyamide inhibits replication of vesicular stomatitis virus by targeting RNA in the nucleocapsid.
Q90963815Pharmacologic Targeting of Hypoxia-Inducible Factors
Q46448023Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis.
Q89157968Targeting Transcription Factors for Cancer Treatment