Constitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrity

scientific article published on June 2008

Constitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.180.11.7485
P932PMC publication ID2410094
P698PubMed publication ID18490749
P5875ResearchGate publication ID5359160

P2093author name stringDouglas R Spitz
Alix Ashare
Gary W Hunninghake
Martha M Monick
Linda S Powers
Dayna J Groskreutz
Toru Nyunoya
Christopher W Barrett
Mitchell Coleman
Sara Hinde
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Active ERK contributes to protein translation by preventing JNK-dependent inhibition of protein phosphatase 1Q79929599
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Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseasesQ31030866
Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activationQ31034955
The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondriaQ33292529
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Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activityQ34328383
How to flip the (redox) switchQ35015887
Kinase signaling cascades in the mitochondrion: a matter of life or death.Q35979108
Glutathione, stress responses, and redox signaling in lung inflammation.Q36009340
The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functionsQ36360691
Energy metabolism of human neutrophils during phagocytosisQ36985938
Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.Q39457088
Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt.Q39528226
Pseudomonas aeruginosa delays Kupffer cell death via stabilization of the X-chromosome-linked inhibitor of apoptosis proteinQ40117830
Complex I binding by a virally encoded RNA regulates mitochondria-induced cell deathQ40125595
RETRACTED: Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212Q40168882
MEK-ERK signaling controls Hdm2 oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm.Q40455851
Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell deathQ40520566
Extracellular signal-regulated kinase activation delays hyperoxia-induced epithelial cell death in conditions of Akt downregulationQ40526073
MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxolQ40537978
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.Q40626751
The MEK/ERK pathway acts upstream of NF kappa B1 (p50) homodimer activity and Bcl-2 expression in a murine B-cell lymphoma cell line. MEK inhibition restores radiation-induced apoptosisQ40640417
Calcium induces cell survival and proliferation through the activation of the MAPK pathway in a human hormone-dependent leukemia cell line, TF-1.Q40663206
Bleomycin-induced apoptosis of alveolar epithelial cells requires angiotensin synthesis de novoQ40672073
Specific inhibition of interferon signal transduction pathways by adenoviral infectionQ40773522
Regulation of energy metabolism in macrophages during hypoxia. Roles of fructose 2,6-bisphosphate and ribose 1,5-bisphosphateQ40803469
THE NATURE OF LEUKEMIC BLOOD CELLS AS DETERMINED BY THEIR METABOLISM.Q40971941
PI3K: downstream AKTion blocks apoptosisQ41351876
Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis.Q42264580
On the mechanism of the anti-inflammatory activity of hexadimethrine bromideQ42371700
Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cellsQ42453027
Human alveolar macrophages and granulocyte-macrophage colony-stimulating factor-induced monocyte-derived macrophages are resistant to H2O2 via their high basal and inducible levels of catalase activityQ42503158
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.Q42800979
Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathwayQ43785527
Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species productionQ44258988
Combined action of ERK and NF kappa B mediates the protective effect of phorbol ester on Fas-induced apoptosis in Jurkat cellsQ44292870
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikisQ44502162
Aggravation of necrotic death of glucose-deprived cells by the MEK1 inhibitors U0126 and PD184161 through depletion of ATP.Q44933919
Reversible assembly of the ATP-binding cassette transporter Mdl1 with the F1F0-ATP synthase in mitochondriaQ44973156
Macrophages survive hyperoxia via prolonged ERK activation due to phosphatase down-regulationQ46497078
Ceramide activates a mitochondrial p38 mitogen-activated protein kinase: a potential mechanism for loss of mitochondrial transmembrane potential and apoptosisQ46717211
Changes in PKC isoforms in human alveolar macrophages compared with blood monocytes.Q47701571
Mitochondrial extracellular signal-regulated kinases 1/2 (ERK1/2) are modulated during brain developmentQ47927602
Human alveolar macrophages are deficient in PTEN. The role of endogenous oxidants.Q53643234
Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells.Q54143825
Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridineQ56879285
Direct evidence for a bone marrow origin of the alveolar macrophage in manQ67482801
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)7485-7496
P577publication date2008-06-01
P1433published inJournal of ImmunologyQ3521441
P1476titleConstitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrity
P478volume180

Reverse relations

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