The synthetic progesterone Norgestrel is neuroprotective in stressed photoreceptor-like cells and retinal explants, mediating its effects via basic fibroblast growth factor, protein kinase A and glycogen synthase kinase 3β signalling.

scientific article published on 10 January 2016

The synthetic progesterone Norgestrel is neuroprotective in stressed photoreceptor-like cells and retinal explants, mediating its effects via basic fibroblast growth factor, protein kinase A and glycogen synthase kinase 3β signalling. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/EJN.13166
P698PubMed publication ID26750157

P50authorThomas G CotterQ61258687
P2093author name stringAlice C Wyse Jackson
P2860cites workHuman basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codonsQ24610347
Nuclear activities of basic fibroblast growth factor: potentiation of low-serum growth mediated by natural or chimeric nuclear localization signalsQ24654177
A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiationQ24679348
Determination of PCR efficiency in chelex-100 purified clinical samples and comparison of real-time quantitative PCR and conventional PCR for detection of Chlamydia pneumoniaeQ24798213
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Identification of a common non-apoptotic cell death mechanism in hereditary retinal degenerationQ27330551
Analyzing real-time PCR data by the comparative C(T) methodQ28131831
Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injuryQ28567090
Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosisQ28577648
Biological augmentation of rotator cuff repair using bFGF-loaded electrospun poly(lactide-co-glycolide) fibrous membranesQ33637025
Regulation of ribosomal S6 protein kinase-p90(rsk), glycogen synthase kinase 3, and beta-catenin in early Xenopus developmentQ33869282
Progesterone attenuates Aβ(25-35)-induced neuronal toxicity via JNK inactivation and progesterone receptor membrane component 1-dependent inhibition of mitochondrial apoptotic pathwayQ48380769
Norgestrel may be a potential therapy for retinal degenerations.Q48636129
Effects of progesterone on neurite growth inhibitors in the hippocampus following global cerebral ischemiaQ48820404
Activation of survival pathways in the degenerating retina of rd10 mice.Q54312217
Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal.Q54415298
Short-term psychosocial stress protects photoreceptors from damage via corticosterone-mediated activation of the AKT pathway.Q54544381
Enhancing survival of photoreceptor cells in vivo using the synthetic progestin Norgestrel.Q54580267
Biochemical analysis of the arginine methylation of high molecular weight fibroblast growth factor-2.Q33888191
Identification and characterization of rod-derived cone viability factorQ33979422
Progesterone in transient ischemic stroke: a dose-response studyQ34053634
Genes and mutations causing retinitis pigmentosaQ34346276
Basic fibroblast growth factor gene expression.Q34687219
Aberrant expression of Beclin-1 and LC3 correlates with poor prognosis of human hypopharyngeal squamous cell carcinomaQ34918935
Antioxidants reduce cone cell death in a model of retinitis pigmentosaQ34983972
Glycogen synthase kinase-3β is a prosurvival signal for the maintenance of human mast cell homeostasisQ35566591
A long-term efficacy study of gene replacement therapy for RPGR-associated retinal degenerationQ35766381
A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosaQ35961539
Basic fibroblast growth factor (FGF-2): the high molecular weight forms come of age.Q36666638
Treatments for spinal cord injury: is there hope in neurosteroids?Q37172354
Photoreceptor cell death mechanisms in inherited retinal degeneration.Q37316717
Methylation of high molecular weight fibroblast growth factor-2 determines post-translational increases in molecular weight and affects its intracellular distributionQ37381980
Endogenous and exogenous fibroblast growth factor 2 support survival of chick retinal neurons by control of neuronal neuronal bcl-x(L) and bcl-2 expression through a fibroblast berowth factor receptor 1- and ERK-dependent pathwayQ38311388
Progesterone receptor signalling in retinal photoreceptor neuroprotectionQ38829565
Effect of vital dyes on retinal pigmented epithelial cell viability and apoptosis: implications for chromovitrectomyQ39095211
Vascular endothelial growth factor regulates primate choroid-retinal endothelial cell proliferation and tube formation through PI3K/Akt and MEK/ERK dependent signalingQ39142088
Inhibition of the PI3K/AKT pathway reduces tumor necrosis factor-alpha production in the cellular response to wear particles in vitroQ39208517
Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta.Q39540268
bFGF-mediated redox activation of the PI3K/Akt pathway in retinal photoreceptor cellsQ39610182
A stress survival response in retinal cells mediated through inhibition of the serine/threonine phosphatase PP2A.Q39679478
Rosiglitazone acts as a neuroprotectant in retinal cells via up-regulation of sestrin-1 and SOD-2.Q39882261
Effects of progesterone, levonorgestrel and medroxyprogesterone acetate on apoptosis in human endometrial endothelial cellsQ39896856
Redox survival signalling in retina-derived 661W cells.Q39993037
bFGF promotes photoreceptor cell survival in vitro by PKA-mediated inactivation of glycogen synthase kinase 3beta and CREB-dependent Bcl-2 up-regulation.Q40090627
Photoreceptor cell apoptosis induced by the 2-nitroimidazole radiosensitizer, CI-1010, is mediated by p53-linked activation of caspase-3.Q40381065
Progesterone neuroprotection in spinal cord trauma involves up-regulation of brain-derived neurotrophic factor in motoneuronsQ40428940
Retinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanismsQ41370456
Multiple forms of bFGF: differential nuclear and cell surface localizationQ41705923
Pathway activation profiling reveals new insights into age-related macular degeneration and provides avenues for therapeutic interventionsQ41807717
Modulation of Mitogenic Activity of Fibroblast Growth Factors by Inorganic PolyphosphateQ42802026
Progesterone attenuates neurological behavioral deficits of experimental autoimmune encephalomyelitis through remyelination with nucleus-sublocalized Olig1 protein.Q43104192
Mice lacking Period 1 and Period 2 circadian clock genes exhibit blue cone photoreceptor defectsQ43864562
Neuroprotection by scatter factor/hepatocyte growth factor and FGF-1 in cerebellar granule neurons is phosphatidylinositol 3-kinase/akt-dependent and MAPK/CREB-independentQ44027709
Progesterone neuroprotection in the Wobbler mouse, a genetic model of spinal cord motor neuron disease.Q44315188
Basis of progesterone protection in spinal cord neurodegenerationQ44371288
Antiproliferative and cytotoxic properties of moxifloxacin on rat retinal ganglion cellsQ44673050
Multiple death pathways in retina-derived 661W cells following growth factor deprivation: crosstalk between caspases and calpains.Q46450573
The role of nitric oxide and cGMP in somatostatin's protection against retinal ischemiaQ46825640
Basic fibroblast growth factor-induced protection from light damage in the mouse retina in vivoQ46844315
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectphotoreceptor proteinQ7187894
P304page(s)899-911
P577publication date2016-02-11
P1433published inEuropean Journal of NeuroscienceQ5412733
P1476titleThe synthetic progesterone Norgestrel is neuroprotective in stressed photoreceptor-like cells and retinal explants, mediating its effects via basic fibroblast growth factor, protein kinase A and glycogen synthase kinase 3β signalling
P478volume43

Reverse relations

cites work (P2860)
Q37652175Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retina
Q90952579Immunological Considerations for Retinal Stem Cell Therapy
Q47649807Microglial-induced Müller cell gliosis is attenuated by progesterone in a mouse model of retinitis pigmentosa
Q54975267Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa.
Q52372755Neuroprotective strategies for retinal disease.
Q38703924Pro-survival redox signalling in progesterone-mediated retinal neuroprotection
Q36182897Progesterone Attenuates Microglial-Driven Retinal Degeneration and Stimulates Protective Fractalkine-CX3CR1 Signaling.
Q47855578Progesterone analogue protects stressed photoreceptors via bFGF-mediated calcium influx.
Q37341998The synthetic progestin norgestrel modulates Nrf2 signaling and acts as an antioxidant in a model of retinal degeneration.