Microglial-induced Müller cell gliosis is attenuated by progesterone in a mouse model of retinitis pigmentosa

scientific article published on 16 October 2017

Microglial-induced Müller cell gliosis is attenuated by progesterone in a mouse model of retinitis pigmentosa is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/GLIA.23243
P698PubMed publication ID29034506

P50authorThomas G CotterQ61258687
P2093author name stringAna M Ruiz-Lopez
Ashleigh M Byrne
Sarah L Roche
Jennifer N Moloney
P2860cites workInduction of gp130-related Cytokines and Activation of JAK2/STAT3 Pathway in Astrocytes Precedes Up-regulation of Glial Fibrillary Acidic Protein in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of NeurodegenerationQ23916363
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Adaptive Müller cell responses to microglial activation mediate neuroprotection and coordinate inflammation in the retinaQ28395317
Retinitis pigmentosaQ29616538
IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucomaQ34268399
Total protein analysis as a reliable loading control for quantitative fluorescent Western blottingQ34983533
Interferon-gamma (IFN-γ)-mediated retinal ganglion cell death in human tyrosinase T cell receptor transgenic mouseQ35107211
Differential expression of GFAP in early v late AMD: a quantitative analysisQ35591390
Microglial phagocytosis of living photoreceptors contributes to inherited retinal degenerationQ36057587
Long-term characterization of retinal degeneration in rd1 and rd10 mice using spectral domain optical coherence tomographyQ36089356
Progesterone Attenuates Microglial-Driven Retinal Degeneration and Stimulates Protective Fractalkine-CX3CR1 Signaling.Q36182897
Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration.Q36242882
Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degenerationQ36294246
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Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal DiseaseQ36418255
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Two mouse retinal degenerations caused by missense mutations in the beta-subunit of rod cGMP phosphodiesterase geneQ36926146
Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG studyQ36990099
The synthetic progestin norgestrel modulates Nrf2 signaling and acts as an antioxidant in a model of retinal degeneration.Q37341998
Regulation of dynamic behavior of retinal microglia by CX3CR1 signalingQ37358579
Gamma-interferon promotes proliferation of adult human astrocytes in vitro and reactive gliosis in the adult mouse brain in vivoQ37574148
Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effectsQ37574340
Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retinaQ37652175
Microglia activation is essential for BMP7-mediated retinal reactive gliosis.Q37739360
Retinal microglia: just bystander or target for therapy?Q38283351
The microglia in healthy and diseased retinaQ38465763
Pro-survival redox signalling in progesterone-mediated retinal neuroprotectionQ38703924
The synthetic progesterone Norgestrel is neuroprotective in stressed photoreceptor-like cells and retinal explants, mediating its effects via basic fibroblast growth factor, protein kinase A and glycogen synthase kinase 3β signalling.Q38805145
Progesterone receptor signalling in retinal photoreceptor neuroprotectionQ38829565
The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and GlaucomaQ39449147
Dap12 expression in activated microglia from retinoschisin-deficient retina and its PU.1-dependent promoter regulationQ40083101
Induction of an interferon‐γ Stat3 response in nerve cells by pre‐treatment with gp130 cytokinesQ40631389
Adalimumab Reduces Photoreceptor Cell Death in A Mouse Model of Retinal Degeneration.Q41458186
Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcificationQ41995272
Astrocytes and Müller Cell Alterations During Retinal Degeneration in a Transgenic Rat Model of Retinitis Pigmentosa.Q42156150
Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosaQ42174317
Detection of early neuron degeneration and accompanying glial responses in the visual pathway in a rat model of acute intraocular hypertensionQ43274465
Alternative activation of STAT1 and STAT3 in response to interferon-gammaQ45000443
Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathyQ46458778
Functional and structural modifications during retinal degeneration in the rd10 mouse.Q46474597
Long-term glial reactivity in rat retinas ipsilateral and contralateral to experimental glaucomaQ46566371
Progesterone analogue protects stressed photoreceptors via bFGF-mediated calcium influx.Q47855578
Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa.Q48301393
Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma.Q53557356
Müller Cell-Microglia Cross Talk Drives Neuroinflammation in Diabetic Retinopathy.Q53932141
Activation of survival pathways in the degenerating retina of rd10 mice.Q54312217
Enhancing survival of photoreceptor cells in vivo using the synthetic progestin Norgestrel.Q54580267
Müller cell changes in human diabetic retinopathyQ74371192
Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pigmentosaQ82266170
Microglia-Müller glia crosstalk in the rd10 mouse model of retinitis pigmentosaQ87512591
Alterations to retinal architecture prior to photoreceptor loss in a mouse model of retinitis pigmentosaQ89397421
P433issue2
P921main subjectmicrogliaQ1622829
P304page(s)295-310
P577publication date2017-10-16
P1433published inGliaQ15716658
P1476titleMicroglial-induced Müller cell gliosis is attenuated by progesterone in a mouse model of retinitis pigmentosa
P478volume66

Reverse relations

cites work (P2860)
Q90703336Diverse Signaling by TGFβ Isoforms in Response to Focal Injury is Associated with Either Retinal Regeneration or Reactive Gliosis
Q92573754Histopathologic Assessment of Optic Nerves and Retina From a Patient With Chronically Implanted Argus II Retinal Prosthesis System
Q90952579Immunological Considerations for Retinal Stem Cell Therapy
Q91788880Lentivirus vector-mediated knockdown of Sox9 shows neuroprotective effects on light damage in rat retinas
Q52372755Neuroprotective strategies for retinal disease.
Q64071806Progesterone, Lipoic Acid, and Sulforaphane as Promising Antioxidants for Retinal Diseases: A Review
Q100526014Sectoral activation of glia in an inducible mouse model of autosomal dominant retinitis pigmentosa
Q64250529The agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia
Q93101882The urokinase-type plasminogen activator system as drug target in retinitis pigmentosa: New pre-clinical evidence in the rd10 mouse model

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