Tasquinimod inhibits prostate cancer growth in bone through alterations in the bone microenvironment

scientific article published on 10 December 2015

Tasquinimod inhibits prostate cancer growth in bone through alterations in the bone microenvironment is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/PROS.23133
P698PubMed publication ID26660725
P5875ResearchGate publication ID286767396

P2093author name stringAnders Olsson
Lisa U Magnusson
Jan-Erik Damber
Karin Welén
Pascale Plas
Malin Hagberg Thulin
P2860cites workS100A9 interaction with TLR4 promotes tumor growthQ21134707
Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamidesQ21145828
Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumorsQ21245714
Global cancer statisticsQ22241238
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic nicheQ24606366
Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironmentQ24618224
Myeloid-derived suppressor cells: linking inflammation and cancerQ24641811
Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 proteinQ24641894
Inflammation and cancerQ24649640
Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cellsQ24658240
Myeloid-derived suppressor cells as regulators of the immune systemQ28131637
Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 studyQ28275476
Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasisQ28275735
HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repressionQ28582316
Osteoblastic cells regulate the haematopoietic stem cell nicheQ29615007
Identification of the haematopoietic stem cell niche and control of the niche sizeQ29615008
Osteomimetic properties of prostate cancer cells: a hypothesis supporting the predilection of prostate cancer metastasis and growth in the bone environmentQ30304016
Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistanceQ30500080
Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1.Q33692449
HDAC4 integrates PTH and sympathetic signaling in osteoblastsQ33797044
Cadherin-11 increases migration and invasion of prostate cancer cells and enhances their interaction with osteoblasts.Q34072879
Phase II randomized, double-blind, placebo-controlled study of tasquinimod in men with minimally symptomatic metastatic castrate-resistant prostate cancerQ34217642
Inhibition of metastasis in a castration resistant prostate cancer model by the quinoline-3-carboxamide tasquinimod (ABR-215050).Q34250496
Identification of ABR-215050 as lead second generation quinoline-3-carboxamide anti-angiogenic agent for the treatment of prostate cancerQ34563829
The quinoline-3-carboxamide anti-angiogenic agent, tasquinimod, enhances the anti-prostate cancer efficacy of androgen ablation and taxotere without effecting serum PSA directly in human xenograftsQ34610434
Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrowQ34755120
The class II histone deacetylase HDAC4 regulates cognitive, metabolic and endocrine functions through its expression in osteoblastsQ35040485
Tasquinimod modulates suppressive myeloid cells and enhances cancer immunotherapies in murine modelsQ35071167
Myeloid-derived suppressor cells regulate natural killer cell response to adenovirus-mediated gene transferQ36414429
The RANK/RANKL/OPG triad in cancer-induced bone diseasesQ36688664
LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasisQ36903532
The bone marrow niche: habitat to hematopoietic and mesenchymal stem cells, and unwitting host to molecular parasitesQ37096553
Cadherin-11 promotes the metastasis of prostate cancer cells to boneQ37100123
Osteoblasts stimulate the osteogenic and metastatic progression of castration-resistant prostate cancer in a novel model for in vitro and in vivo studiesQ37558837
Tumor-associated macrophages (TAM) as major players of the cancer-related inflammationQ37594369
Paradoxical roles of IL-4 in tumor immunityQ37651680
Premetastatic niche: ready for new therapeutic interventions?Q37996455
The rationale for targeting the LOX family in cancerQ38027412
Effect of radium-223 dichloride on symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases: results from a phase 3, double-blind, randomised trialQ38212374
Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype.Q39224283
N-cadherin increases after androgen deprivation and is associated with metastasis in prostate cancerQ39726974
Prostate cancer cells modulate osteoblast mineralisation and osteoclast differentiation through Id-1.Q39763199
Altered expression of genes regulating angiogenesis in experimental androgen-independent prostate cancerQ40036320
Long-term Safety and Antitumor Activity in the Phase 1-2 Study of Enzalutamide in Pre- and Post-docetaxel Castration-Resistant Prostate CancerQ41029729
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrowQ41788910
Tasquinimod prevents the angiogenic rebound induced by fractionated radiation resulting in an enhanced therapeutic response of prostate cancer xenograftsQ41836745
Molecular mechanisms of the inhibitory effect of lipopolysaccharide (LPS) on osteoblast differentiationQ42841776
Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenanceQ43129066
S100A8/S100A9 and their association with cartilage and boneQ46279555
Cell-to-cell contact is critical for the survival of hematopoietic progenitor cells on osteoblasts.Q51328919
P433issue4
P304page(s)383-393
P577publication date2015-12-10
P1433published inThe ProstateQ7758608
P1476titleTasquinimod inhibits prostate cancer growth in bone through alterations in the bone microenvironment
P478volume76

Reverse relations

cites work (P2860)
Q28072232Cell and Signal Components of the Microenvironment of Bone Metastasis Are Affected by Hypoxia
Q26748872Diagnostic, prognostic and predictive value of cell-free miRNAs in prostate cancer: a systematic review
Q40468733Phase Ib Trial of Cabazitaxel and Tasquinimod in Men With Heavily Pretreated Metastatic Castration Resistant Prostate Cancer (mCRPC): The CATCH Trial.

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