Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways

scientific article published on 12 November 2015

Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PTR.5517
P8608Fatcat IDrelease_efkxfl365nfjvl2wr3vyqva2dq
P698PubMed publication ID26560814

P2093author name stringKuan-Hung Lin
Hou-Chang Chiu
Ray-Jade Chen
Li-Ming Lien
Ming-Yi Shen
Duen-Suey Chou
Joen-Rong Sheu
Meng-Jiy Wang
Wan-Jung Lu
Jia-Lun Wu
P2860cites workComprehensive genomic characterization defines human glioblastoma genes and core pathwaysQ24656128
Heterogeneity of epidermal growth factor receptor signalling networks in glioblastomaQ27013006
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastomaQ27860910
Synergistic anti-inflammatory effects of nobiletin and sulforaphane in lipopolysaccharide-stimulated RAW 264.7 cellsQ28731439
The WHO classification of tumors of the nervous systemQ33845646
G1 cell-cycle control and cancerQ34368858
Inhibitory effects of nobiletin on hepatocellular carcinoma in vitro and in vivoQ34789103
The challenges and the promise of molecular targeted therapy in malignant gliomasQ35214534
The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancers via the Akt pathwayQ35636447
Therapeutic advances in the treatment of glioblastoma: rationale and potential role of targeted agentsQ36395924
The effectiveness and cost-effectiveness of carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma: a systematic review and economic evaluationQ37000030
A highly invasive human glioblastoma pre-clinical model for testing therapeuticsQ37103825
Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob miceQ38346573
Nobiletin inhibits invasion and migration of human nasopharyngeal carcinoma cell lines by involving ERK1/2 and transcriptional inhibition of MMP-2.Q38922626
Nobiletin induces inhibitions of Ras activity and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling to suppress cell proliferation in C6 rat glioma cells.Q39172844
Resveratrol reduces the invasive growth and promotes the acquisition of a long-lasting differentiated phenotype in human glioblastoma cellsQ39577641
Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR miceQ39997059
A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cellsQ40041651
Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cellsQ40188424
Evaluation of the effects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitroQ40713972
Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model miceQ43495733
Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese miceQ44693111
Fruit, vegetable, and antioxidant intake and all-cause, cancer, and cardiovascular disease mortality in a community-dwelling population in Washington County, MarylandQ45176780
Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivoQ45185161
Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease.Q46547320
Flavonoid composition of fruit tissues of citrus speciesQ46905583
Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD).Q48208900
Nobiletin, a polymethoxy flavonoid, suppresses bone resorption by inhibiting NFκB-dependent prostaglandin E synthesis in osteoblasts and prevents bone loss due to estrogen deficiency.Q48925017
Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function.Q55068125
P433issue2
P921main subjectcell migrationQ189092
cell growthQ189159
P304page(s)214-221
P577publication date2015-11-12
P1433published inPhytotherapy ResearchQ7189844
P1476titleNobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways
P478volume30

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cites work (P2860)
Q471638745,6,7,3',4',5'-Hexamethoxyflavone inhibits growth of triple-negative breast cancer cells via suppression of MAPK and Akt signaling pathways and arresting cell cycle
Q38698041Antioxidant Capacity, Anticancer Ability and Flavonoids Composition of 35 Citrus (Citrus reticulata Blanco) Varieties.
Q38740714CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners
Q28066511Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?
Q92237885Nobiletin Inhibits Cell Viability via the SRC/AKT/STAT3/YY1AP1 Pathway in Human Renal Carcinoma Cells
Q64265285Nobiletin induces growth inhibition and apoptosis in human nasopharyngeal carcinoma C666-1 cells through regulating PARP-2/SIRT1/AMPK signaling pathway
Q98159365Nobiletin inhibits cell growth through restraining aerobic glycolysis via PKA-CREB pathway in oral squamous cell carcinoma
Q37376512Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression
Q64122876ROS generation and autophagosome accumulation contribute to the DMAMCL-induced inhibition of glioma cell proliferation by regulating the ROS/MAPK signaling pathway and suppressing the Akt/mTOR signaling pathway
Q28079806The Multifunctional Effects of Nobiletin and Its Metabolites In Vivo and In Vitro

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