Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

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Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives? is …
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review articleQ7318358
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P356DOI10.3390/NU8110698
P932PMC publication ID5133085
P698PubMed publication ID27827912

P50authorSebastiano GangemiQ42724685
Gioacchino CalapaiQ37368499
Santa CirmiQ38361949
Alessandro MaugeriQ103822986
Giuseppe Angelo Giovanni LombardoQ63676175
P2093author name stringNadia Ferlazzo
Michele Navarra
P2860cites workSuppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by apigenin via the inhibition of p38 mitogen-activated protein kinase-dependent matrix metalloproteinase-9 expressionQ43049471
Effect of naringin on the DNA damage induced by daunorubicin in mouse hepatocytes and cardiocytes.Q43089665
Apigenin Induces Apoptosis through a Mitochondria/Caspase-Pathway in Human Breast Cancer MDA-MB-453 CellsQ43138260
Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db miceQ43242148
Effect of nobiletin on K562 cells xenograft in nude miceQ43273170
The chemopreventive bioflavonoid apigenin inhibits prostate cancer cell motility through the focal adhesion kinase/Src signaling mechanismQ43279507
Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells.Q43573086
Inhibitory effect of naringin on the micronuclei induced by ifosfamide in mouse, and evaluation of its modulatory effect on the Cyp3a subfamilyQ43708309
Inhibitory effect of mandarin juice rich in beta-cryptoxanthin and hesperidin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary tumorigenesis in miceQ43786678
Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matriQ43893142
Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoterQ43895329
Effects of several flavonoids on the growth of B16F10 and SK-MEL-1 melanoma cell lines: relationship between structure and activity.Q43945430
Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cellsQ44007849
Food groups and laryngeal cancer risk: a case-control study from Italy and SwitzerlandQ44062559
Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cellsQ44177064
A protective effect of the Mediterranean diet for cutaneous melanomaQ44225124
Dietary fruit and vegetables protect against somatic mutation in vivo, but low or high intake of carotenoids does not.Q44427330
Citrus fruit and cancer risk in a network of case-control studies.Q44598693
Quercetin inhibits the invasion of murine melanoma B16-BL6 cells by decreasing pro-MMP-9 via the PKC pathwayQ44639500
Chemotherapeutic effect of tangeretin, a polymethoxylated flavone studied in 7, 12-dimethylbenz(a)anthracene induced mammary carcinoma in experimental ratsQ44658051
Molecular mechanisms for apigenin-induced cell-cycle arrest and apoptosis of hormone refractory human prostate carcinoma DU145 cellsQ44747184
Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transportQ44854938
Naringenin inhibits glucose uptake in MCF-7 breast cancer cells: a mechanism for impaired cellular proliferationQ44866182
Mechanisms underlying the anti-tumoral effects of Citrus Bergamia juiceQ21133561
Cancer chemoprevention by citrus pulp and juices containing high amounts of β-cryptoxanthin and hesperidinQ21285045
Hallmarks of Cancer: The Next GenerationQ22252312
Induction of cancer-specific cytotoxicity towards human prostate and skin cells using quercetin and ultrasoundQ24650438
Vitamin C: update on physiology and pharmacologyQ24654791
Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytesQ24678624
Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesisQ24808665
Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisionsQ26261171
Citrus fruit intake and breast cancer risk: a quantitative systematic reviewQ34339770
Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinoma cell through ROS generation and cell cycle arrest.Q34351949
The comprehensive approach to diet: a critical reviewQ34428612
Vegetable and fruit intake and pancreatic cancer in a population-based case-control study in the San Francisco bay areaQ34452190
Chemistry and pharmacology of the Citrus bioflavonoid hesperidinQ34464892
Preserved foods in relation to risk of nasopharyngeal carcinoma in Shanghai, ChinaQ34506907
Potential synergy of phytochemicals in cancer prevention: mechanism of actionQ34552949
Association between fruit and vegetable consumption and oral cancer: a meta-analysis of observational studiesQ34567375
Inhibition of oral carcinogenesis by citrus flavonoids.Q34591213
Hesperidin protects renal and hepatic tissues against free radical-mediated oxidative stress during DMBA-induced experimental breast cancerQ34634408
In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agentQ34639366
The citrus methoxyflavone tangeretin affects human cell-cell interactions.Q34706432
Molecular targets for nutrients involved with cancer preventionQ34718681
Bioactive compounds from Mexican lime ( Citrus aurantifolia ) juice induce apoptosis in human pancreatic cells.Q35013291
Cancer prevention -- the potential for diet to modulate molecular signallingQ35043753
Tangeretin, a citrus polymethoxyflavonoid, induces apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathwaysQ35103563
Hesperetin induces the apoptosis of hepatocellular carcinoma cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species, ATP and calciumQ35571150
Intake of fruits, vegetables and selected micronutrients in relation to the risk of breast cancerQ35607528
Pure total flavonoids from Citrus paradisi Macfadyen act synergistically with arsenic trioxide in inducing apoptosis of Kasumi-1 leukemia cells in vitroQ35687542
In vitro effect of bergamot (Citrus bergamia) juice against cagA-positive and-negative clinical isolates of Helicobacter pyloriQ35721183
Evidence for activation of mutated p53 by apigenin in human pancreatic cancerQ35751608
Citrus Fruit Intake Substantially Reduces the Risk of Esophageal Cancer: A Meta-Analysis of Epidemiologic StudiesQ35795097
Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrestQ35804007
Tangeretin sensitizes cisplatin-resistant human ovarian cancer cells through downregulation of phosphoinositide 3-kinase/Akt signaling pathway.Q35869232
Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G(2)/M arrest and apoptosisQ35923012
Poncirin Induces Apoptosis in AGS Human Gastric Cancer Cells through Extrinsic Apoptotic Pathway by up-Regulation of Fas LigandQ36184282
Fruit and vegetable consumption is inversely associated with having pancreatic cancerQ36467889
Didymin reverses phthalate ester-associated breast cancer aggravation in the breast cancer tumor microenvironmentQ36524400
Regulation of the p14ARF-Mdm2-p53 pathway: an overview in breast cancerQ36571008
Food groups and colorectal cancer riskQ36617566
Food groups, oils and butter, and cancer of the oral cavity and pharynxQ36617958
Hesperidin from Citrus seed induces human hepatocellular carcinoma HepG2 cell apoptosis via both mitochondrial and death receptor pathwaysQ36827731
Naringenin reduces lung metastasis in a breast cancer resection model.Q36922668
Citrus fruit intake and stomach cancer risk: a quantitative systematic reviewQ37121683
An update of the WCRF/AICR systematic literature review on esophageal and gastric cancers and citrus fruits intakeQ26751453
Anti-inflammatory/antioxidant use in long-term maintenance cancer therapy: a new therapeutic approach to disease progression and recurrenceQ27010314
Inflammation and cancer: back to Virchow?Q28036756
Anti-Inflammatory Activity of Citrus bergamia Derivatives: Where Do We Stand?Q28075161
Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?Q28076243
Fruits and vegetables intake and risk of bladder cancer: a PRISMA-compliant systematic review and dose-response meta-analysis of prospective cohort studiesQ28088417
Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial growth factor from human tumor cellsQ28240326
Flavonoids: antioxidants or signalling molecules?Q28250292
Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitroQ28266942
The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cellsQ28268168
Inhibition of bacterial mutagenesis by Citrus flavonoidsQ28283692
Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated ratsQ28283845
Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activityQ28285710
Suppression of colon carcinogenesis by bioactive compounds in grapefruitQ28289446
Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juicesQ28293845
Effect of P-glycoprotein modulators on the pharmacokinetics of camptothecin using microdialysisQ28363738
Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis studyQ28379302
Natural products as sources of new drugs over the last 25 yearsQ29615119
The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancerQ29617123
Cancer chemoprevention with dietary phytochemicalsQ29617743
Biological properties of citrus flavonoids pertaining to cancer and inflammationQ31922880
Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell linesQ33178761
Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosminQ33221824
Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoidsQ33552810
hesperidin induces paraptosis like cell death in hepatoblastoma, HepG2 Cells: involvement of ERK1/2 MAPK [corrected].Q33825927
Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft modelsQ34040058
Bergamot juice extract inhibits proliferation by inducing apoptosis in human colon cancer cellsQ34041849
Flavonoids: structural requirements for antiproliferative activity on breast cancer cellsQ34103052
Lapatinib induces autophagic cell death and inhibits growth of human hepatocellular carcinomaQ34104067
Cancer prevention with natural compoundsQ34131211
The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice.Q34243734
Combination of Ethanolic Extract of Citrus aurantifolia Peels with Doxorubicin Modulate Cell Cycle and Increase Apoptosis Induction on MCF-7 Cells.Q34256324
Flavonoid fraction of Bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-κB inhibition in THP-1 monocytes.Q34258055
Molecular targets of apigenin in colorectal cancer cells: involvement of p21, NAG-1 and p53.Q34332568
Cytotoxicity and antiproliferative activities of several phenolic compounds against three melanocytes cell lines: relationship between structure and activityQ45110715
Do dietary lycopene and other carotenoids protect against prostate cancer?Q45130519
Flavonoid apigenin inhibits motility and invasiveness of carcinoma cells in vitroQ45137604
Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivoQ45185161
Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cellsQ45278642
Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in ratsQ45306912
Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.Q45919911
Modulatory efficacy of hesperetin (citrus flavanone) on xenobiotic-metabolizing enzymes during 1,2-dimethylhydrazine-induced colon carcinogenesis.Q45982356
Effects of quercetin on proliferation, apoptosis, adhesion and migration, and invasion of HeLa cellsQ46076987
Naringenin reduces tumor size and weight lost in N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in ratsQ46197881
Correlation between antiangiogenic activity and antioxidant activity of various components from propolisQ46209022
Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in miceQ46428684
Risk factors for the development of second primary tumors among men after laryngeal and hypopharyngeal carcinomaQ46456049
Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cellsQ46483152
Modulatory effect of naringenin on N-methyl-N'-nitro-N-nitrosoguanidine- and saturated sodium chloride-induced gastric carcinogenesis in male Wistar ratsQ46531161
Natural iron chelators: Protective role in A549 cells of flavonoids-rich extracts of Citrus juices in Fe(3+)-induced oxidative stressQ46570215
Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in rats.Q46583886
Flavonoid quercetin, but not apigenin or luteolin, induced apoptosis in human myeloid leukemia cells and their resistant variants.Q46628564
Naringin accelerates the regression of pre-neoplastic lesions and the colorectal structural reorganization in a murine model of chemical carcinogenesisQ46894566
Flavonoid composition of fruit tissues of citrus speciesQ46905583
Citrus aurantium L. exhibits apoptotic effects on U937 human leukemia cells partly through inhibition of Akt.Q47228303
The Anticonvulsant Activity of a Flavonoid-Rich Extract from Orange Juice Involves both NMDA and GABA-Benzodiazepine Receptor Complexes.Q48040686
Naringin suppresses the development of glioblastoma by inhibiting FAK activityQ48787229
Effects of citrus flavonoids on the mutagenicity of heterocyclic amines and on cytochrome P450 1A2 activityQ50117776
Anti-inflammatory and Antioxidant Effects of Flavonoid-Rich Fraction of Bergamot Juice (BJe) in a Mouse Model of Intestinal Ischemia/Reperfusion Injury.Q42419286
Modulation of N-methyl-N-amylnitrosamine-induced rat oesophageal tumourigenesis by dietary feeding of diosmin and hesperidin, both alone and in combinationQ42437102
Flavonoids inhibit VEGF/bFGF-induced angiogenesis in vitro by inhibiting the matrix-degrading proteasesQ42441688
Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary-bladder carcinogenesis in male ICR miceQ42448104
Effects of nobiletin on PhIP-induced prostate and colon carcinogenesis in F344 rats.Q42483616
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: comparison with the protective effect of beta-caroteneQ42496565
Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells.Q42507939
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats by flavonoids diosmin and hesperidin, each alone and in combination.Q42528835
Anthocyanins and their role in cancer preventionQ37197566
Perspectives for cancer prevention with natural compoundsQ37212228
Citrus fruit intake and pancreatic cancer risk: a quantitative systematic reviewQ37282234
Hormonal and metabolic modulation through nutrition: towards a primary prevention of breast cancerQ37764591
Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapyQ37782112
Chemopreventive effect of dietary polyphenols in colorectal cancer cell linesQ37854984
Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activitiesQ37982235
Cranberry and recurrent cystitis: more than marketing?Q38185445
Citrus bergamia Juice Extract Attenuates β-Amyloid-Induced Pro-Inflammatory Activation of THP-1 Cells Through MAPK and AP-1 PathwaysQ38281514
Nobiletin induces apoptosis and potentiates the effects of the anticancer drug 5-fluorouracil in p53-mutated SNU-16 human gastric cancer cellsQ38452910
Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expressionQ38502150
Antimutagenic effect of plant flavonoids in the Salmonella assay systemQ38532466
Food groups and risk of colorectal cancer in ItalyQ38557216
Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt PathwaysQ38820034
Co-treatment of THP-1 cells with naringenin and curcumin induces cell cycle arrest and apoptosis via numerous pathwaysQ38825478
Chemopreventive effects of orange peel extract (OPE). I: OPE inhibits intestinal tumor growth in ApcMin/+ miceQ80246903
Chemoprotective effects of hesperidin against genotoxicity induced by cyclophosphamide in mice bone marrow cellsQ81478674
Anti-/pro-apoptotic effects of hesperetin against 7,12-dimetylbenz(a)anthracene-induced alteration in animalsQ82927753
Naringin inhibits tumor growth and reduces interleukin-6 and tumor necrosis factor α levels in rats with Walker 256 carcinosarcomaQ83166327
Enhancement of transglutaminase activity and polyamine depletion in B16-F10 melanoma cells by flavonoids naringenin and hesperitin correlate to reduction of the in vivo metastatic potentialQ83340318
Antiproliferative efficacy of hesperetin (citrus flavanoid) in 1,2-dimethylhydrazine-induced colon cancerQ84815308
Attenuation of NDEA-induced hepatocarcinogenesis by naringenin in ratsQ85505065
Inhibitory effect of naringenin (citrus flavonone) on N-nitrosodiethylamine induced hepatocarcinogenesis in ratsQ86478853
Citrus fruit intake and bladder cancer risk: a meta-analysis of observational studiesQ88087048
Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastomaQ95820838
Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3).Q39595000
Flavonoids inhibit angiogenic cytokine production by human glioma cells.Q39618089
Inactivation of nuclear factor-κB by citrus flavanone hesperidin contributes to apoptosis and chemo-sensitizing effect in Ramos cellsQ39636717
Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cellsQ39641608
Naringenin promote apoptosis in cerebrally implanted C6 glioma cellsQ39666449
Nobiletin, a citrus polymethoxyflavonoid, suppresses multiple angiogenesis‐related endothelial cell functions and angiogenesis in vivoQ39673866
Naringenin up‐regulates the expression of death receptor 5 and enhances TRAIL‐induced apoptosis in human lung cancer A549 cellsQ39673949
Simultaneous quantitative monitoring of drug-induced caspase cascade pathways in carcinoma cellsQ39703393
Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE(2) activationQ39791378
Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell linesQ39795079
Didymin, a dietary flavonoid glycoside from citrus fruits, induces Fas-mediated apoptotic pathway in human non-small-cell lung cancer cells in vitro and in vivoQ39802992
Hesperidin suppressed proliferations of both human breast cancer and androgen-dependent prostate cancer cellsQ39834520
The flavonols quercetin, kaempferol, and myricetin inhibit hepatocyte growth factor-induced medulloblastoma cell migration.Q39879515
Naringenin enhances the anti-tumor effect of doxorubicin through selectively inhibiting the activity of multidrug resistance-associated proteins but not P-glycoproteinQ39907311
Nobiletin inhibits epithelial-mesenchymal transition of human non-small cell lung cancer cells by antagonizing the TGF-β1/Smad3 signaling pathwayQ39913283
Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinaseQ39923195
Naringenin induces apoptosis through downregulation of Akt and caspase-3 activation in human leukemia THP-1 cellsQ39927949
Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line A549 in vitro and in vivoQ39996504
Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR miceQ39997059
Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cellsQ40011807
A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cellsQ40041651
Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cellsQ40062174
Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21.Q40069899
Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4.Q40075860
NF-κB mediates the antiproliferative and proapoptotic effects of bergamot juice in HepG2 cellsQ40110654
Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cellsQ40188424
Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrestQ40188770
Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expressionQ40214504
Mechanism of apoptosis with the involvement of calpain and caspase cascades in human malignant neuroblastoma SH-SY5Y cells exposed to flavonoidsQ40229191
Phenylbenzopyrones structure-activity studies identify betuletol derivatives as potential antitumoral agentsQ40236979
Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3).Q40286264
Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated inhibition of breast cancer resistance proteinQ40404753
Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancerQ40411474
Tangeretin inhibits extracellular-signal-regulated kinase (ERK) phosphorylation.Q40448514
Citrus Reticulata blanco induces apoptosis in human gastric cancer cells SNU-668.Q40450253
Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice.Q40451449
Apigenin induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway.Q40483066
Effects of grapefruit juice on the multidrug transporter P-glycoprotein in the human proximal tubular cell line HK-2.Q40494738
Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: antiproliferative effects, induction of apoptosis and cell cycle deregulationQ40527746
Phytoestrogens are potent inhibitors of estrogen sulfation: implications for breast cancer risk and treatment.Q40568902
Interaction of the breast cancer resistance protein with plant polyphenolsQ40573021
The Chemopreventive Bioflavonoid Apigenin Modulates Signal Transduction Pathways in Keratinocyte and Colon Carcinoma Cell LinesQ40618180
Apigenin Induces Apoptosis through Proteasomal Degradation of HER2/neu in HER2/neu-overexpressing Breast Cancer Cells via the Phosphatidylinositol 3-Kinase/Akt-dependent PathwayQ40619186
Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoidsQ40632212
The variable effect on proliferation of a colon cancer cell line by the citrus fruit flavonoid NaringeninQ40643407
Effects of several polyhydroxylated flavonoids on the growth of B16F10 melanoma and Melan-a melanocyte cell lines: influence of the sequential oxidation state of the flavonoid skeletonQ40672708
Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potentialQ40678335
Flavonoid Fraction of Orange and Bergamot Juices Protect Human Lung Epithelial Cells from Hydrogen Peroxide-Induced Oxidative StressQ40683657
Evaluation of the effects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitroQ40713972
The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID miceQ40762288
Apigenin acts on the tumor cell invasion process and regulates protease productionQ40776545
Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice.Q40851574
Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell linesQ40867773
Flavonoids activate wild-type p53.Q41158056
Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanismQ41436320
Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible targetQ41502857
Studies on the differentiation inducers of myeloid leukemic cells from Citrus species.Q41560868
Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK PathwayQ41745925
Chemopreventive effects of nobiletin and its colonic metabolites on colon carcinogenesisQ38829756
Flavonoid Fraction of Citrus reticulata Juice Reduces Proliferation and Migration of Anaplastic Thyroid Carcinoma CellsQ38835612
Anti-infective potential of Citrus bergamia Risso et Poiteau (bergamot) derivatives: a systematic reviewQ38842926
Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cellsQ38850387
Effects of bergamot essential oil and its extractive fractions on SH-SY5Y human neuroblastoma cell growthQ38895237
Nobiletin inhibits invasion and migration of human nasopharyngeal carcinoma cell lines by involving ERK1/2 and transcriptional inhibition of MMP-2.Q38922626
Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line.Q38929588
Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF‑κB/COX‑2‑caspase-1 pathway in HeLa cervical cancer cellsQ38961293
Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cellsQ38962284
Neuroprotection by association of palmitoylethanolamide with luteolin in experimental Alzheimer's disease models: the control of neuroinflammation.Q38967778
Naringenin inhibits migration of bladder cancer cells through downregulation of AKT and MMP‑2.Q38975898
Naringin suppress chondrosarcoma migration through inhibition vascular adhesion molecule-1 expression by modulating miR-126.Q38979915
Clinical Pharmacology of Citrus bergamia: A Systematic ReviewQ38982325
Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cellsQ39085322
Flavonoid apigenin modified gene expression associated with inflammation and cancer and induced apoptosis in human pancreatic cancer cells through inhibition of GSK-3β/NF-κB signaling cascadeQ39110471
Intake of fruit and vegetables and risk of bladder cancer: a dose-response meta-analysis of observational studiesQ39124528
Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathwayQ39149078
Nobiletin induces inhibitions of Ras activity and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling to suppress cell proliferation in C6 rat glioma cells.Q39172844
Induction of the cell cycle arrest and apoptosis by flavonoids isolated from Korean Citrus aurantium L. in non-small-cell lung cancer cellsQ39278480
The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathwaysQ39293024
Antimetastatic effect of nobiletin through the down-regulation of CXC chemokine receptor type 4 and matrix metallopeptidase-9.Q39304192
Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cellsQ39305542
Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cellsQ39360179
PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K-Akt-MDM2 signaling suppressionQ39404215
Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line--a comparative studyQ39432891
Apoptosis-mediated inhibition of human breast cancer cell proliferation by lemon citrus extractQ39435805
Evaluation of chemopreventive and cytotoxic effect of lemon seed extracts on human breast cancer (MCF-7) cellsQ39447735
Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation.Q39505782
Effects of dietary flavonoids, luteolin, and quercetin on the reversal of epithelial-mesenchymal transition in A431 epidermal cancer cells.Q39507443
1,2,3,4,6-penta-O-galloyl-β-D-glucose, quercetin, curcumin and lycopene induce cell-cycle arrest in MDA-MB-231 and BT474 cells through downregulation of Skp2 proteinQ39539242
The citrus flavonoid hesperidin induces p53 and inhibits NF-κB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARγ-dependent mechanism.Q39569040
Drug combinations with quercetin: doxorubicin plus quercetin in human breast cancer cellsQ39576769
Hesperetin, a potential therapy for carcinoid cancerQ39583082
Citrus consumption and cancer incidence: the Ohsaki cohort study.Q50568200
The role of diet and other environmental factors in the causation of gastric cancer in Iran--a population based study.Q50604248
Prospective study of fruits and vegetables and risk of oral premalignant lesions in men.Q50722834
Vegetables and fruits consumption and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study.Q51852218
Suppression by apigenin of peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats.Q53392573
Minor effects of the citrus flavonoids naringin, naringenin and quercetin, on the pharmacokinetics of doxorubicin in rats.Q53418978
Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin.Q53443691
Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice.Q53509827
Chemopreventive effects of orange peel extract (OPE). II: OPE inhibits atypical hyperplastic lesions in rodent mammary gland.Q53556175
Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft.Q53625146
Naringin, a natural dietary compound, prevents intestinal tumorigenesis in Apc (Min/+) mouse model.Q53646650
NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation.Q54198974
The anti-inflammatory and antioxidant effects of bergamot juice extract (BJe) in an experimental model of inflammatory bowel disease.Q54303089
Chemopreventive efficacy of hesperetin (citrus flavonone) against 1,2-dimethylhydrazine-induced rat colon carcinogenesis.Q54319665
Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6/STAT3 pathway.Q54515968
Quercetin protects human-derived liver cells against mercury-induced DNA-damage and alterations of the redox statusQ57236621
Fruit and vegetable intake and the risk of gastric adenocarcinoma: A reanalysis of the european prospective investigation into cancer and nutrition (EPIC-EURGAST) study after a longer follow-upQ57252064
Fruit and vegetable consumption and pancreatic cancer risk in the European Prospective Investigation into Cancer and NutritionQ57271377
Type II estrogen binding sites and antiproliferative activity of quercetin in human meningiomasQ70521271
Isolation of anti-leukemia compounds from Citrus reticulataQ71040785
Protection from UV-B-induced DNA damage by flavonoidsQ72776205
Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cellsQ73033886
Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoidQ73147455
Preventive effect of hesperidin against inflammation in CD-1 mouse skin caused by tumor promoterQ73397101
Induction of p21/WAF1 and G1 cell-cycle arrest by the chemopreventive agent apigeninQ73484107
Food groups and risk of squamous cell esophageal cancer in northern ItalyQ73911369
Inhibition of azoxymethane-induced colon cancer by orange juiceQ73979904
Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potentialQ74081784
Suppression of azoxymethane-induced colon carcinogenesis in male F344 rats by mandarin juices rich in beta-cryptoxanthin and hesperidinQ74234541
Inhibition of mammary cancer by citrus flavonoidsQ77440730
Inhibitory effect of Hesperidin on tumour initiation and promotion in mouse skinQ77444802
Inhibitory effect of apigenin on benzo(a)pyrene-mediated genotoxicity in Swiss albino miceQ79853388
Suppression of tumor growth and invasion in 9,10 dimethyl benz(a) anthracene induced mammary carcinoma by the plant bioflavonoid quercetinQ79920810
Naringenin-induced apoptosis via activation of NF-kappaB and necrosis involving the loss of ATP in human promyeloleukemia HL-60 cellsQ79965685
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectfruitQ1364
neoplasmQ1216998
anticarcinogensQ4774590
CitrusQ81513
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)698
P577publication date2016-11-04
P1433published inNutrientsQ7070485
P1476titleChemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?
P478volume8

Reverse relations

cites work (P2860)
Q33854738Anticancer Potential of Citrus Juices and Their Extracts: A Systematic Review of Both Preclinical and Clinical Studies
Q48243050Chiral separation of novel iminonaringenin derivatives
Q94548342Citrus Peel Flavonoids as Potential Cancer Prevention Agents
Q40067756Consumption of fruits, vegetables, and risk of hematological malignancies: a systematic review and meta-analysis of prospective studies.
Q57591520Dietary Flavonoids and the Risk of Colorectal Cancer: An Updated Meta-Analysis of Epidemiological Studies
Q37734375Effectiveness of Citrus Fruits on Helicobacter pylori
Q90750096Effects of a Flavonoid-Rich Extract from Citrus sinensis Juice on a Diet-Induced Obese Zebrafish
Q93079853Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels
Q61811849Flavonoids in Cancer and Apoptosis
Q89477374Fruits
Q64253284Moringin from Seeds Inhibits Growth, Arrests Cell-Cycle, and Induces Apoptosis of SH-SY5Y Human Neuroblastoma Cells through the Modulation of NF-κB and Apoptotic Related Factors
Q99404916New Plant Breeding Techniques in Citrus for the Improvement of Important Agronomic Traits. A Review
Q90376675Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
Q61814320Treatment With a Flavonoid-Rich Fraction of Bergamot Juice Improved Lipopolysaccharide-Induced Periodontitis in Rats

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