Nobiletin, a citrus polymethoxyflavonoid, suppresses multiple angiogenesis‐related endothelial cell functions and angiogenesis in vivo

scientific article published on November 1, 2010

Nobiletin, a citrus polymethoxyflavonoid, suppresses multiple angiogenesis‐related endothelial cell functions and angiogenesis in vivo is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1349-7006.2010.01668.X
P953full work available at URLhttps://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1349-7006.2010.01668.x
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1349-7006.2010.01668.x
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.2010.01668.x
P932PMC publication ID11158917
P698PubMed publication ID20670297
P5875ResearchGate publication ID45423031

P50authorYukio YamoriQ24063269
P2093author name stringSachi Kuranuki
Masahiko Ikekita
Kazuhiro Kunimasa
Mayumi Sato
Megumi Ikeda
Toshiro Ohta
Tsutomu Oikawa
P2860cites workCellular signaling by fibroblast growth factor receptorsQ24301087
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Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivoQ28371943
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesisQ29547178
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesisQ29617585
The chick embryo chorioallantoic membrane as a model for in vivo research on anti-angiogenesisQ34316079
Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activityQ34457597
Sp1 phosphorylation by Erk 2 stimulates DNA bindingQ34489381
Brazilian Propolis Suppresses Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells through Inactivation of Survival Signal ERK1/2.Q35109424
Molecular diagnosis of tumor angiogenesis and anti-angiogenic cancer therapyQ35211646
VEGF-receptor signal transductionQ35296110
Angiogenesis and signal transduction in endothelial cellsQ35874931
Urokinase-type plasminogen activator is induced in migrating capillary endothelial cellsQ36217171
Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretionQ39875880
Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line A549 in vitro and in vivoQ39996504
A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cellsQ40041651
Dipalmitoylation of radicicol results in improved efficacy against tumor growth and angiogenesis in vivoQ40181971
Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cellsQ40188424
Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesisQ40377374
Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: antiproliferative effects, induction of apoptosis and cell cycle deregulationQ40527746
Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophagesQ40642412
The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID miceQ40762288
Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-inflammatory polymethoxyflavonoidQ40824222
Three novel synthetic retinoids, Re 80, Am 580 and Am 80, all exhibit anti-angiogenic activity in vivoQ41660336
Plasminogen activators augment endothelial cell organization in vitro by two distinct pathwaysQ41668424
Signal transducers and activators of transcription mediate fibroblast growth factor-induced vascular endothelial morphogenesisQ41815867
Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells.Q42507939
Nonsteroidal anti-inflammatory drugs inhibit matrix metalloproteinase-2 via suppression of the ERK/Sp1-mediated transcriptionQ42522960
Mechanism of Adult Primitive Mesenchymal ST-13 Preadipocyte DifferentiationQ42801851
Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytesQ42829233
Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2.Q42833675
Dietary administration of citrus nobiletin inhibits azoxymethane-induced colonic aberrant crypt foci in ratsQ43697620
A potential use of a synthetic retinoid TAC-101 as an orally active agent that blocks angiogenesis in liver metastases of human stomach cancer cellsQ43803390
Phorbol ester induction of angiotensin-converting enzyme transcription is mediated by Egr-1 and AP-1 in human endothelial cells via ERK1/2 pathwayQ44217923
Effects of rhizoxin, a microbial angiogenesis inhibitor, on angiogenic endothelial cell functionsQ44275822
Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in ratsQ45306912
Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-kappaB, AP-1, and Sp1 activationQ46763143
Flavonoid composition of fruit tissues of citrus speciesQ46905583
Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formationQ47745076
The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells.Q52573380
ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesisQ58001185
Inhibition of angiogenesis by vitamin D3 analoguesQ67657266
Antitumor effect of 22-oxa-1α,25-dihydroxyvitamin D3 a potent angiogenesis inhibitor, on rat mammary tumors induced by 7, 12-dimethylbenz[a]anthraceneQ67712006
Urokinase-type plasminogen activator mediates basic fibroblast growth factor-induced bovine endothelial cell migration independent of its proteolytic activityQ67738387
A highly potent antiangiogenic activity of retinoidsQ69113896
Medroxyprogesterone acetate, an anti-cancer and anti-angiogenic steroid, inhibits the plasminogen activator in bovine endothelial cellsQ69114475
Radicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesisQ72106388
Barriers to drug delivery in solid tumorsQ72141985
A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblastsQ73385942
Vascular endothelial growth factor activates STAT proteins in aortic endothelial cellsQ74232904
The proteasome is involved in angiogenesisQ74586034
Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells. Evidence for a dual kinase mechanismQ77900470
Antiangiogenic effects of indole-3-carbinol and 3,3'-diindolylmethane are associated with their differential regulation of ERK1/2 and Akt in tube-forming HUVECQ84848256
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectCitrusQ81513
endotheliumQ111140
angiogenesisQ539568
P304page(s)2462-2469
P577publication date2010-11-01
P1433published inCancer ScienceQ326125
P1476titleNobiletin, a citrus polymethoxyflavonoid, suppresses multiple angiogenesis-related endothelial cell functions and angiogenesis in vivo
Nobiletin, a citrus polymethoxyflavonoid, suppresses multiple angiogenesis‐related endothelial cell functions and angiogenesis in vivo
P478volume101

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cites work (P2860)
Q50043004Antiangiogenic Effect of Flavonoids and Chalcones: An Update.
Q34177531Anticancer activities of citrus peel polymethoxyflavones related to angiogenesis and others
Q38283152Bioactive Flavonoids, Antioxidant Behaviour, and Cytoprotective Effects of Dried Grapefruit Peels (Citrus paradisi Macf.).
Q58810742Characterization and Antiproliferative Activity of Nobiletin-Loaded Chitosan Nanoparticles
Q28066511Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?
Q94548342Citrus Peel Flavonoids as Potential Cancer Prevention Agents
Q35634433Exogenously-added copper/zinc superoxide dismutase rescues damage of endothelial cells from lethal irradiation
Q34639366In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent
Q33754877Nobiletin Inhibits Angiogenesis by Regulating Src/FAK/STAT3-Mediated Signaling through PXN in ER⁺ Breast Cancer Cells
Q38922626Nobiletin inhibits invasion and migration of human nasopharyngeal carcinoma cell lines by involving ERK1/2 and transcriptional inhibition of MMP-2.
Q34417473Nobiletin suppresses cell viability through AKT pathways in PC-3 and DU-145 prostate cancer cells
Q53701902Nobiletin-Ameliorated Lipopolysaccharide-Induced Inflammation in Acute Lung Injury by Suppression of NF-κB Pathway In Vivo and Vitro.
Q34632484Resveratrol derivative-rich melinjo (Gnetum gnemon L.) seed extract suppresses multiple angiogenesis-related endothelial cell functions and tumor angiogenesis
Q35636447The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancers via the Akt pathway
Q38540713The potential of fibroblast growth factor/fibroblast growth factor receptor signaling as a therapeutic target in tumor angiogenesis.
Q92289418Transdermal delivery of nobiletin using ionic liquids

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