Pembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): a multicentre, open-label, phase 1b trial

scientific article published on 3 May 2016

Pembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): a multicentre, open-label, phase 1b trial is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1470-2045(16)00175-3
P698PubMed publication ID27157491

P50authorHyun Cheol ChungQ59647646
Yung-Jue BangQ16180903
P2093author name stringDung T Le
Minori Koshiji
Talia Golan
Chia-Chi Lin
Shilpa Gupta
Kei Muro
Autumn J McRee
Barbara Burtness
Veena Shankaran
Kenneth Emancipator
Ravit Geva
Jonathan Juco
Jared Lunceford
Joseph Paul Eder
Daniel Catenacci
Kumudu Pathiraja
P2860cites workDevelopment of a Prototype Immunohistochemistry Assay to Measure Programmed Death Ligand-1 Expression in Tumor TissueQ38377655
PD-L1 expression analysis in gastric carcinoma tissue and blocking of tumor-associated PD-L1 signaling by two functional monoclonal antibodiesQ40185070
Expression of B7-H1 on gastric epithelial cells: its potential role in regulating T cells during Helicobacter pylori infectionQ40313152
Phase I Study of Pembrolizumab (MK-3475; Anti-PD-1 Monoclonal Antibody) in Patients with Advanced Solid Tumors.Q41228724
Association of PD-L1 expression on tumor-infiltrating mononuclear cells and overall survival in patients with urothelial carcinomaQ43788672
Prognostic implications of immunosuppressive protein expression in tumors as well as immune cell infiltration within the tumor microenvironment in gastric cancer.Q53249720
Gastric cancerQ57758203
Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significanceQ82793374
Correlation between infiltration of FOXP3+ regulatory T cells and expression of B7-H1 in the tumor tissues of gastric cancerQ87494688
Expression of costimulatory molecules B7-H1, B7-H4 and Foxp3+ Tregs in gastric cancer and its clinical significanceQ87827796
Gastric cancer: prevention, screening and early diagnosisQ26860418
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The blockade of immune checkpoints in cancer immunotherapyQ27860852
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PD-1 and its ligands in tolerance and immunityQ28131650
Comprehensive molecular characterization of gastric adenocarcinomaQ28244985
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Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trialQ29620814
Pembrolizumab for the treatment of non-small-cell lung cancerQ29620851
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escapeQ29620881
Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trialQ29620917
Medical management of gastric cancer: a 2014 updateQ34326546
Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trialQ34670965
Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancerQ35113261
Heterogeneity of amplification of HER2, EGFR, CCND1 and MYC in gastric cancerQ35554809
Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunityQ35870655
P433issue6
P921main subjectmulticenter clinical trialQ6934595
pembrolizumabQ13896859
P304page(s)717-726
P577publication date2016-05-03
P1433published inLancet Oncology CommissionQ13747613
P1476titlePembrolizumab for patients with PD-L1-positive advanced gastric cancer (KEYNOTE-012): a multicentre, open-label, phase 1b trial
P478volume17

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