Lysyl oxidase is associated with the epithelial-mesenchymal transition of gastric cancer cells in hypoxia

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Lysyl oxidase is associated with the epithelial-mesenchymal transition of gastric cancer cells in hypoxia is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1032555653
P356DOI10.1007/S10120-015-0510-3
P698PubMed publication ID26100130

P2093author name stringKosei Hirakawa
Masakazu Yashiro
Masaichi Ohira
Tatsunari Fukuoka
Hiroaki Kasashima
Naoshi Kubo
Haruhito Kinoshita
Tamami Morisaki
Katsunobu Sakurai
Go Masuda
P2860cites workA molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progressionQ24314451
Matrix crosslinking forces tumor progression by enhancing integrin signalingQ24646370
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Tumor hypoxia: definitions and current clinical, biologic, and molecular aspectsQ28200181
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cellQ28208372
A molecular role for lysyl oxidase in breast cancer invasionQ28216721
RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasisQ28236828
Elastic fiber homeostasis requires lysyl oxidase-like 1 proteinQ28240976
Lysyl oxidase mediates hypoxic control of metastasisQ28271667
Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancyQ28276295
Metalloproteinase activity secreted by fibrogenic cells in the processing of prolysyl oxidase. Potential role of procollagen C-proteinaseQ28279434
Fully processed lysyl oxidase catalyst translocates from the extracellular space into nuclei of aortic smooth-muscle cellsQ28568824
Metalloproteinase Activity Secreted by Fibrogenic Cells in the Processing of Prolysyl OxidaseQ29544584
Establishment and characterization of a new hypoxia-resistant cancer cell line, OCUM-12/Hypo, derived from a scirrhous gastric carcinomaQ30493513
Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomasQ30544282
LOXL as a target to increase the elastin content in adult skin: a dill extract induces the LOXL gene expressionQ33250251
Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast culturesQ33943363
Lysyl oxidase-related protein-1 promotes tumor fibrosis and tumor progression in vivoQ34187677
Reduction of LOX- and LOXL2-mRNA expression in head and neck squamous cell carcinomas.Q34207894
Hypoxia stimulates the EMT of gastric cancer cells through autocrine TGFβ signalingQ34729819
Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cellsQ35134466
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formationQ35239845
Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer.Q35746400
Establishment of two new scirrhous gastric cancer cell lines: analysis of factors associated with disseminated metastasisQ36081321
Lysyl oxidase, extracellular matrix remodeling and cancer metastasisQ36284915
Notch signaling mediates hypoxia-induced tumor cell migration and invasionQ36609130
Upregulated expression of LOX is a novel independent prognostic marker of worse outcome in gastric cancer patients after curative surgeryQ36621104
Hypoxia-inducible factors: central regulators of the tumor phenotypeQ36701590
Hypoxia inducible factor 1α-mediated LOX expression correlates with migration and invasion in epithelial ovarian cancerQ36866279
LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasisQ36903532
Three-dimensional context regulation of metastasisQ37111021
The tumor microenvironment and metastatic diseaseQ37187529
Immunohistochemical detection of changes in tumor hypoxiaQ37188441
MCF-7 cells expressing nuclear associated lysyl oxidase-like 2 (LOXL2) exhibit an epithelial-to-mesenchymal transition (EMT) phenotype and are highly invasive in vitro.Q37233956
Lysyl oxidase-like 2 (LOXL2) from stromal fibroblasts stimulates the progression of gastric cancerQ38965504
Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathwaysQ38989588
Lysyl oxidase may play a critical role in hypoxia-induced NSCLC cells invasion and migrationQ39247251
Transcriptional profiling identifies upregulated genes following induction of epithelial-mesenchymal transition in squamous carcinoma cellsQ39431215
Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironmentQ39659310
Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1alpha, GLUT1, and CAIX.Q39696387
Hypoxia upregulates adhesion ability to peritoneum through a transforming growth factor-beta-dependent mechanism in diffuse-type gastric cancer cellsQ39741655
Tumor suppressive effect of lysyl oxidase proenzymeQ39857576
Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomasQ39971722
Detecting changes in tumor hypoxia with carbonic anhydrase IX and pimonidazoleQ40195317
Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.Q40514759
Peritoneal metastatic model for human scirrhous gastric carcinoma in nude miceQ41257371
LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition.Q41957208
The tumor suppressor activity of the lysyl oxidase propeptide reverses the invasive phenotype of Her-2/neu-driven breast cancer.Q42831276
Lysyl oxidase-like protein from bovine aorta. Isolation and maturation to an active form by bone morphogenetic protein-1.Q43783344
Identification of silencing of nine genes in human gastric cancers.Q44220770
Hypoxic cervical cancers with low apoptotic index are highly aggressive.Q45128481
Lysyl oxidase expression in bronchogenic carcinoma.Q46406027
Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanismQ46853176
Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling.Q54596208
Expression of a hypoxia-associated protein, carbonic anhydrase-9, correlates with malignant phenotypes of gastric carcinomaQ84501443
Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cellsQ85486101
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)431-442
P577publication date2015-06-23
P1433published inGastric CancerQ15724608
P1476titleLysyl oxidase is associated with the epithelial-mesenchymal transition of gastric cancer cells in hypoxia
P478volume19

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cites work (P2860)
Q41977476Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis
Q61454345Divergent roles of lysyl oxidase family members in ornithine decarboxylase- and RAS-transformed mouse fibroblasts and human melanoma cells
Q90172102Effect of Hypoxia on Gene Expression in Cell Populations Involved in Wound Healing
Q55276271Evaluation of Fluorine-18-Labeled α1(I)-N-Telopeptide Analogs as Substrate-Based Radiotracers for PET Imaging of Melanoma-Associated Lysyl Oxidase.
Q89587251Gastric Tumor Microenvironment
Q61447507Identification of potential biomarkers of lung adenocarcinoma brain metastases via microarray analysis of cDNA expression profiles
Q58764034Inhibition of lysyl oxidase expression by dextran sulfate affects invasion and migration of gastric cancer cells
Q37631469Lysyl Oxidase and the Tumor Microenvironment
Q49177437Lysyl oxidase activates cancer stromal cells and promotes gastric cancer progression: quantum dot-based identification of biomarkers in cancer stromal cells
Q92666152Lysyl oxidase induces epithelial-mesenchymal transition and predicts intrahepatic metastasis of hepatocellular carcinoma
Q38937873Lysyl oxidase isoforms in gastric cancer.
Q89701164MFAP2 is overexpressed in gastric cancer and promotes motility via the MFAP2/integrin α5β1/FAK/ERK pathway
Q55318272Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation.
Q55318093Role of Bone Morphogenetic Protein 7 (BMP7) in the Modulation of Corneal Stromal and Epithelial Cell Functions.
Q61804904TBL1 is required for the mesenchymal phenotype of transformed breast cancer cells
Q47205727The fibrotic tumor stroma
Q99350038Transcriptional analysis of cleft palate in TGFβ3 mutant mice
Q36369565Uncovering the role of nuclear Lysyl oxidase (LOX) in advanced high grade serous ovarian cancer

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