Immunologic Targets in Atopic Dermatitis and Emerging Therapies: An Update

scientific article

Immunologic Targets in Atopic Dermatitis and Emerging Therapies: An Update is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P6179Dimensions Publication ID1008901133
P356DOI10.1007/S40257-016-0205-5
P698PubMed publication ID27371134

P2093author name stringLisa A Beck
Diane Wang
P2860cites workInterleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial.Q53536137
Inadequate response to ustekinumab in atopic dermatitis - a report of two patients.Q53668118
Activation of TLR2 enhances tight junction barrier in epidermal keratinocytes.Q54567889
Induction of beta-defensin 3 in keratinocytes stimulated by bacterial lipopeptides through toll-like receptor 2.Q54601882
Toll-like receptor 2 (TLR2) mediates intracellular signalling in human keratinocytes in response to Malassezia furfur.Q54631753
Possible Pathogenic Role of Th17 Cells for Atopic DermatitisQ56772998
Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthmaQ24681031
The role of microorganisms in atopic dermatitisQ24683941
Immune Pathways in Atopic Dermatitis, and Definition of Biomarkers through Broad and Targeted TherapeuticsQ26799532
Barrier Epithelial Cells and the Control of Type 2 ImmunityQ26801045
Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approachesQ26852335
Functional activity of serotoninergic and melatoninergic systems expressed in the skinQ28206451
Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in miceQ28265772
IL-31: a new link between T cells and pruritus in atopic skin inflammationQ28295839
IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitisQ28295850
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitisQ28303063
Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasisQ30525640
Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studiesQ30957004
Cost of atopic dermatitis and eczema in the United StatesQ33183415
Targeting interleukin-13 with tralokinumab attenuates lung fibrosis and epithelial damage in a humanized SCID idiopathic pulmonary fibrosis model.Q33799732
Molecular mechanisms of IgE regulationQ33835041
Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis.Q33849441
Exome sequencing of filaggrin and related genes in African-American children with atopic dermatitisQ33916764
Th2 cytokines increase Staphylococcus aureus alpha toxin-induced keratinocyte death through the signal transducer and activator of transcription 6 (STAT6)Q33916807
Filaggrin mutations associated with skin and allergic diseases.Q34223419
Differential in situ cytokine gene expression in acute versus chronic atopic dermatitisQ34229692
Anti-immunoglobulin E in the treatment of refractory atopic dermatitisQ34307177
Treatment of recalcitrant atopic dermatitis with the oral Janus kinase inhibitor tofacitinib citrateQ34486040
Proteases as Th2 adjuvantsQ34662936
Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjectsQ34782224
Structures and biological functions of IL-31 and IL-31 receptorsQ34858355
Safety and efficacy of baricitinib at 24 weeks in patients with rheumatoid arthritis who have had an inadequate response to methotrexateQ35048395
Atopic dermatitis: a disease of altered skin barrier and immune dysregulationQ35065037
Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapiesQ35077866
Guidelines of care for the management of atopic dermatitis: section 3. Management and treatment with phototherapy and systemic agentsQ35539576
Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor BaricitinibQ35800753
Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing SpondylitisQ35877149
Functions of thymic stromal lymphopoietin in immunity and diseaseQ35953900
Mechanistic correlations between two itch biomarkers, cytokine interleukin-31 and neuropeptide β-endorphin, via STAT3/calcium axis in atopic dermatitisQ36351112
T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements.Q36503230
Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6Q36509379
Activation of epidermal toll-like receptor 2 enhances tight junction function: implications for atopic dermatitis and skin barrier repairQ36692559
A pilot study of an oral phosphodiesterase inhibitor (apremilast) for atopic dermatitis in adultsQ36734928
Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseasesQ36775280
Climatic factors are associated with childhood eczema prevalence in the United States.Q36821478
"Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis.Q37137538
Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4.Q37175971
Cathelicidin deficiency predisposes to eczema herpeticumQ37307447
Crisaborole Topical Ointment, 2% in Patients Ages 2 to 17 Years with Atopic Dermatitis: A Phase 1b, Open-Label, Maximal-Use Systemic Exposure StudyQ37375523
A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.Q37397800
Cellular and molecular mechanisms in atopic dermatitisQ37499326
IL-5- and eosinophil-mediated inflammation: from discovery to therapyQ37612636
A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1.Q37649820
Extrinsic and intrinsic types of atopic dermatitisQ37703808
Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis.Q37709674
Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitisQ37709681
Type 2 innate immune responses and the natural helper cell.Q37842599
Contrasting pathogenesis of atopic dermatitis and psoriasis--part II: immune cell subsets and therapeutic conceptsQ37855007
The cutaneous innate immune response in patients with atopic dermatitis.Q38078473
Efficacy of allergen-specific immunotherapy for atopic dermatitis: a systematic review and meta-analysis of randomized controlled trials.Q38104457
Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: a systematic reviewQ38165590
Type 2 Innate Lymphoid Cells in Allergic DiseaseQ38216020
IL-17 and infectionsQ38268322
The JAK-STAT pathway: impact on human disease and therapeutic interventionQ38317993
Emerging biologics for the treatment of chronic rhinosinusitisQ38344266
Risk of Serious Infection With Biologic and Systemic Treatment of Psoriasis: Results From the Psoriasis Longitudinal Assessment and Registry (PSOLAR).Q38411653
Type 2 cytokines: mechanisms and therapeutic strategiesQ38424752
Interleukin 4 inhibition as a potential therapeutic in pemphigusQ38600160
Targeting key proximal drivers of type 2 inflammation in diseaseQ38608260
Secukinumab Inhibition of Interleukin-17A in Patients with Psoriatic ArthritisQ38958215
The Toll-like receptor 2 R753Q mutation modifies cytokine production and Toll-like receptor expression in atopic dermatitisQ40018839
IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3.Q40109996
Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trialQ40445632
Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial.Q40672713
The phosphodiesterase 4 inhibitor roflumilast is effective in the treatment of allergic rhinitisQ40682613
Endogenous antimicrobial peptides and skin infections in atopic dermatitisQ40698186
Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitisQ41719738
Severe refractory atopic dermatitis in an adolescent patient successfully treated with ustekinumabQ42575535
Association of HLA-DRB1 alleles with clinical responses to the anti-interleukin-17A monoclonal antibody secukinumab in active rheumatoid arthritisQ42639324
Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responsesQ42944667
Dysregulation of CD36 upon TLR-2 stimulation in monocytes from patients with atopic dermatitis and the TLR2 R753Q polymorphismQ43256713
OPA-15406, a novel, topical, nonsteroidal, selective phosphodiesterase-4 (PDE4) inhibitor, in the treatment of adult and adolescent patients with mild to moderate atopic dermatitis (AD): A phase-II randomized, double-blind, placebo-controlled studyQ43692258
Effects of an anti-TSLP antibody on allergen-induced asthmatic responsesQ44096664
The effects of the novel SHIP1 activator AQX-1125 on allergen-induced responses in mild-to-moderate asthma.Q44102880
Association of the toll-like receptor 2 A-16934T promoter polymorphism with severe atopic dermatitisQ44413966
Dupilumab in persistent asthma with elevated eosinophil levelsQ44480181
Tralokinumab for moderate-to-severe UC: a randomised, double-blind, placebo-controlled, phase IIa studyQ44696806
Novel filaggrin mutation but no other loss-of-function variants found in Ethiopian patients with atopic dermatitis.Q44971096
Pharmacokinetic Profile, Safety, and Tolerability of Crisaborole Topical Ointment, 2% in Adolescents with Atopic Dermatitis: An Open-Label Phase 2a StudyQ46098786
Impact of a soluble phospholipase A2 inhibitor on inhaled allergen challenge in subjects with asthmaQ46413563
Anti-IL-5 recombinant humanized monoclonal antibody (mepolizumab) for the treatment of atopic dermatitis.Q46424938
Prevalence of IgE-mediated food allergy among children with atopic dermatitis.Q46629938
Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen-induced asthmatic reactionsQ46637522
Transgenic mice which overproduce Th2 cytokines develop spontaneous atopic dermatitis and asthmaQ47265833
Differential in vivo cytokine mRNA expression in lesional skin of intrinsic vs. extrinsic atopic dermatitis patients using semiquantitative RT-PCR.Q47341670
Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genesQ47640250
The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placQ47933206
The toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotypeQ47984267
Safety and efficacy of topical E6005, a phosphodiesterase 4 inhibitor, in Japanese adult patients with atopic dermatitis: results of a randomized, vehicle-controlled, multicenter clinical trialQ48099089
Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesionsQ50232370
Efficacy and safety of intravenous secukinumab in noninfectious uveitis requiring steroid-sparing immunosuppressive therapy.Q52870118
Quality of life in atopic dermatitis.Q53480974
P433issue5
P921main subjectatopic dermatitisQ268667
P304page(s)425-443
P577publication date2016-07-01
P1433published inAmerican Journal of Clinical DermatologyQ18616212
P1476titleImmunologic Targets in Atopic Dermatitis and Emerging Therapies: An Update
P478volume17

Reverse relations

cites work (P2860)
Q47383323A safety review of the medications used to treat atopic dermatitis
Q45601105Atopic Dermatitis in Animals and People: An Update and Comparative Review
Q47602738Atopic Dermatitis: Disease Background and Risk Factors
Q50057530Atopic dermatitis physiopathology
Q64993836Consensus on the therapeutic management of atopic dermatitis - Brazilian Society of Dermatology.
Q50094027Crisaborole Ointment 2%: A Review in Mild to Moderate Atopic Dermatitis
Q55074071Emollient treatment of atopic dermatitis: latest evidence and clinical considerations.
Q26739986Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis
Q54110780Severe Atopic Dermatitis in Children.
Q47880524The Future of Atopic Dermatitis Treatment
Q33838470Therapeutic Applications of Rose Hips from Different Rosa Species.

articles: null.

Warning: Trying to access array offset on value of type null in /home/httpd/vhosts/renenyffenegger.ch/opendata.renenyffenegger.ch/Wikimedia/Wikidata/entity/main.php on line 1120 Warning: Trying to access array offset on value of type null in /home/httpd/vhosts/renenyffenegger.ch/opendata.renenyffenegger.ch/Wikimedia/Wikidata/entity/main.php on line 1120

Warning: foreach() argument must be of type array|object, null given in /home/httpd/vhosts/renenyffenegger.ch/opendata.renenyffenegger.ch/Wikimedia/Wikidata/entity/main.php on line 1122

Search more.