Heterocycle Formation via Palladium-Catalyzed C-H Functionalization

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Heterocycle Formation via Palladium-Catalyzed C-H Functionalization is …
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scholarly articleQ13442814

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P356DOI10.1055/S-0031-1289766
P932PMC publication ID4936280
P698PubMed publication ID27397938

P50authorKeary M EngleQ49956200
P2093author name stringJin-Quan Yu
Tian-Sheng Mei
Lei Kou
Sandy Ma
P2860cites workRu-, Rh-, and Pd-catalyzed C-C bond formation involving C-H activation and addition on unsaturated substrates: reactions and mechanistic aspectsQ78066242
Synthesis of 3-(diarylmethylenyl)oxindole by a palladium-catalyzed domino carbopalladation/C-H activation/C-C bond-forming processQ79186659
Palladium-catalyzed synthesis of 2-substituted benzothiazoles via a C-H functionalization/intramolecular C-S bond formation processQ79692942
Novel acetoxylation and C-C coupling reactions at unactivated positions in alpha-amino acid derivativesQ79888871
Transition-metal-catalyzed reactions in heterocyclic synthesisQ80073280
The catalytic cross-coupling of unactivated arenesQ80382134
Biaryl synthesis via direct arylation: establishment of an efficient catalyst for intramolecular processesQ80391227
Palladium-catalyzed C-H activation/intramolecular amination reaction: a new route to 3-aryl/alkylindazolesQ80535178
Synthesis of rhazinicine by a metal-catalyzed C-H bond functionalization strategyQ80865640
Pd(II)-catalyzed enantioselective activation of C(sp2)-H and C(sp3)-H bonds using monoprotected amino acids as chiral ligandsQ81289986
Elements of regiocontrol in palladium-catalyzed oxidative arene cross-couplingQ81321398
Combined C-H functionalization/C-N bond formation route to carbazolesQ81365824
Pd(II)-catalyzed monoselective ortho halogenation of C-H bonds assisted by counter cations: a complementary method to directed ortho lithiationQ81396586
Multiple C-H activations to construct biologically active molecules in a process completely free of organohalogen and organometallic componentsQ81557742
High-yielding palladium-catalyzed intramolecular alkane arylation: reaction development and mechanistic studiesQ81559366
Carbon-fluorine reductive elimination from a high-valent palladium fluorideQ81615269
High-yielding intramolecular direct arylation reactions with aryl chloridesQ81674878
Preparation of benzolactams by Pd(II)-catalyzed carbonylation of N-unprotected arylethylaminesQ82465285
Palladium-catalyzed direct arylation of simple arenes in synthesis of biaryl moleculesQ82830308
Functionalization of organic molecules by transition-metal-catalyzed C(sp3)-H activationQ82837929
Intramolecular oxidative C-H coupling for medium-ring synthesisQ83073371
Catalytic dehydrogenative cross-coupling: forming carbon-carbon bonds by oxidizing two carbon-hydrogen bondsQ83579479
Intramolecular oxidative C-N bond formation for the synthesis of carbazoles: comparison of reactivity between the copper-catalyzed and metal-free conditionsQ83741384
Construction of nitrogen-containing heterocycles by C-H bond functionalizationQ83827400
Heterocycle formation via palladium-catalyzed intramolecular oxidative C-H bond functionalization: an efficient strategy for the synthesis of 2-aminobenzothiazolesQ83935218
Palladium-catalyzed dehydrogenative direct arylations of 1,2,3-triazolesQ83961169
A practical strategy for the structural diversification of aliphatic scaffolds through the palladium-catalyzed picolinamide-directed remote functionalization of unactivated C(sp3)-H bondsQ84022764
Palladium-catalyzed oxidative cyclization of 3-phenoxyacrylates: an approach to construct substituted benzofurans from phenolsQ84034956
Synthesis of dibenzofurans via palladium-catalyzed phenol-directed C-H activation/C-O cyclizationQ84186640
Fused indolines by palladium-catalyzed asymmetric C-C coupling involving an unactivated methylene groupQ84499139
Palladium(II)-catalyzed selective monofluorination of benzoic acids using a practical auxiliary: a weak-coordination approachQ84544137
Palladium-catalyzed intramolecular C(sp2)-H amidination by isonitrile insertion provides direct access to 4-aminoquinazolines from N-arylamidinesQ84700616
Enantioselective synthesis of 2-methyl indolines by palladium catalysed asymmetric C(sp3)-H activation/cyclisationQ84959315
Transition Metal Catalyzed Coupling Reactions under C-H ActivationQ88519835
Aryl-aryl bond formation one century after the discovery of the Ullmann reactionQ28216892
The atom economy--a search for synthetic efficiencyQ28252628
Palladium-Catalyzed Ligand-Directed C−H Functionalization ReactionsQ29012891
Weak coordination as a powerful means for developing broadly useful C-H functionalization reactionsQ30410596
Synthesis of quinazolin-4(3H)-ones via Pd(II)-catalyzed intramolecular C(sp2)-H carboxamidation of N-arylamidinesQ33450845
Pd(II)-catalyzed enantioselective C-H olefination of diphenylacetic acidsQ33592501
Carbon-heteroatom bond formation catalysed by organometallic complexesQ33642210
Rhodium-catalyzed C-C bond formation via heteroatom-directed C-H bond activationQ33645846
Auxiliary-assisted palladium-catalyzed arylation and alkylation of sp2 and sp3 carbon-hydrogen bondsQ33737426
Pd(II)-catalyzed olefination of sp3 C-H bondsQ33738148
Total synthesis of (±)-cycloclavine and (±)-5-epi-cycloclavineQ33881189
Pd(II)-catalyzed hydroxyl-directed C-H olefination enabled by monoprotected amino acid ligandsQ33899813
Synthesis and functionalization of indoles through palladium-catalyzed reactionsQ34433267
Aromatic substitution of olefins. VI. Arylation of olefins with palladium(II) acetateQ34535495
Understanding and exploiting C-H bond activationQ34661308
Transition-metal-catalyzed direct arylation of (hetero)arenes by C-H bond cleavage.Q35016847
Pd(II)-Catalyzed Carbonylation of C(sp3)−H Bonds: A New Entry to 1,4-Dicarbonyl CompoundsQ35103618
Heterocycle synthesis via direct C-H/N-H couplingQ35670227
Palladium(0)-catalyzed intermolecular amination of unactivated C(sp³)-H bondsQ36145643
Synthesis of heterocycles via palladium-catalyzed oxidative addition.Q36648001
Aryl-aryl bond formation by transition-metal-catalyzed direct arylation.Q36702962
Sigma-chelation-directed C-H functionalizations using Pd(II) and Cu(II) catalysts: regioselectivity, stereoselectivity and catalytic turnoverQ36741282
Direct transition metal-catalyzed functionalization of heteroaromatic compoundsQ36852312
Function-oriented synthesis, step economy, and drug designQ37045266
Palladium(II)-catalyzed C-H activation/C-C cross-coupling reactions: versatility and practicalityQ37294999
Pd(0)/PR3-catalyzed intermolecular arylation of sp3 C-H bondsQ37307778
Palladium-catalyzed method for the synthesis of carbazoles via tandem C-H functionalization and C-N bond formation.Q37357302
Redox economy in organic synthesisQ37417218
Pd-catalyzed intramolecular oxidative C-H amination: synthesis of carbazoles.Q50518660
Synthesis of N-protected staurosporinones.Q51063825
Preparation of benzolactams by Pd(OAc)2-catalyzed direct aromatic carbonylation.Q51588711
Organometallic chemistry: C-H activation.Q53199987
Highly efficient syntheses of azetidines, pyrrolidines, and indolines via palladium catalyzed intramolecular amination of C(sp3)-H and C(sp2)-H bonds at γ and δ positions.Q53393802
Total synthesis of celogentin C by stereoselective C-H activation.Q53485759
Activation of C−H Bonds by Metal ComplexesQ55933283
Intermolecular Amidation of Unactivated sp2and sp3C−H Bonds via Palladium-Catalyzed Cascade C−H Activation/Nitrene InsertionQ56028858
Palladium-Catalyzed Direct Synthesis of Carbazoles via One-PotN-Arylation and Oxidative Biaryl Coupling: Synthesis and Mechanistic StudyQ57261576
Palladium-Catalyzed sp3CH Activation of Simple Alkyl Groups: Direct Preparation of Indoline Derivatives fromN-Alkyl-2-bromoanilinesQ57261602
One-Pot Formation of CC and CN Bonds through Palladium-Catalyzed Dual CH Activation: Synthesis of PhenanthridinonesQ57614639
Catalytic and Highly Regioselective Cross-Coupling of Aromatic C−H SubstratesQ57944544
Palladium-Catalyzed Fluorination of Carbon−Hydrogen BondsQ57944590
Palladium-Catalyzed Methylation and Arylation of sp2and sp3C−H Bonds in Simple Carboxylic AcidsQ59350168
Organocatalytic, Oxidative, Intramolecular CH Bond Amination and Metal-free Cross-Amination of Unactivated Arenes at Ambient TemperatureQ64027956
Palladium-Catalyzed Double CH Activation Directed by Sulfoxides in the Synthesis of DibenzothiophenesQ64027958
New method for preparation of coumarins and quinolinones via Pd-catalyzed intramolecular hydroarylation of C-C triple bondsQ73185791
Efficient activation of aromatic C-H bonds for addition to C-C multiple bondsQ73556201
Catalytic functionalization of arenes and alkanes via C-H bond activationQ74401937
Anion-Accelerated Palladium-Catalyzed Intramolecular Coupling of Phenols with Aryl HalidesQ74835095
Bystanding F+ oxidants enable selective reductive elimination from high-valent metal centers in catalysisQ37832211
C-H functionalization logic in total synthesisQ37836434
Transition metal-catalyzed arylation of unactivated C(sp3)-H bondsQ37867002
Total synthesis and structural revision of the piperarborenines via sequential cyclobutane C-H arylationQ39361097
Palladium- and copper-catalyzed arylation of carbon-hydrogen bondsQ39818764
Mechanism of C-F reductive elimination from palladium(IV) fluoridesQ39973971
Room-temperature palladium-catalyzed C-H activation: ortho-carbonylation of aniline derivativesQ41951011
Aerobic Pd-catalyzed sp3 C-H olefination: a route to both N-heterocyclic scaffolds and alkenesQ42097723
Ligand-accelerated C-H activation reactions: evidence for a switch of mechanismQ42161197
Versatile Pd(OTf)2 x 2 H2O-catalyzed ortho-fluorination using NMP as a promoterQ42163150
Synthesis and reactivity of a mono-sigma-aryl palladium(IV) fluoride complexQ42557757
N-acylsulfonamide assisted tandem C-H olefination/annulation: synthesis of isoindolinonesQ42636203
syn-1,2-Amino alcohols via diastereoselective allylic C-H aminationQ42938646
Intramolecular palladium-catalyzed alkane C-H arylation from aryl chloridesQ42948149
Investigation of the Mechanism of C(sp3)−H Bond Cleavage in Pd(0)-Catalyzed Intramolecular Alkane Arylation Adjacent to Amides and SulfonamidesQ42948152
Facile benzo-ring construction via palladium-catalyzed functionalization of unactivated sp3 C-H bonds under mild reaction conditionsQ43003394
Expedient drug synthesis and diversification via ortho-C-H iodination using recyclable PdI2 as the precatalyst.Q43021577
An efficient transformation from benzyl or allyl halides to aryl and alkenyl nitriles.Q43053905
Palladium-catalyzed intramolecular amidation of C(sp2)-H bonds: synthesis of 4-aryl-2-quinolinonesQ43072170
Catalytic intermolecular linear allylic C-H amination via heterobimetallic catalysisQ43078965
Distinct reactivity of Pd(OTs)2: the intermolecular Pd(II)-catalyzed 1,2-carboamination of dienesQ43139123
Palladium-catalyzed amination of aromatic C-H bonds with oxime estersQ43148246
C-C bond formation via double C-H functionalization: aerobic oxidative coupling as a method for synthesizing heterocoupled biarylsQ43203010
Synthetic applications of Pd(II)-catalyzed C-H carboxylation and mechanistic insights: expedient routes to anthranilic acids, oxazolinones, and quinazolinonesQ43225960
Palladium-catalyzed amidation of unactivated C(sp(3))-H bonds: from anilines to indolinesQ43293505
Selective synthesis of 3-aryl quinolin-2(1H)-ones and 3-(1-arylmethylene)oxindoles involving a 2-fold arene C-H activation processQ43298874
Direct oxidative Heck cyclizations: intramolecular Fujiwara-Moritani arylations for the synthesis of functionalized benzofurans and dihydrobenzofuransQ43778014
A short synthetic route to (+)-austamide, (+)-deoxyisoaustamide, and (+)-hydratoaustamide from a common precursor by a novel palladium-mediated indole --> dihydroindoloazocine cyclizationQ44048696
Catalytic C-H bond functionalization with palladiumII: aerobic oxidative annulations of indolesQ44540120
Synthesis of Substituted Oxindoles from α-Chloroacetanilides via Palladium-Catalyzed C−H FunctionalizationQ44602269
Synthesis of the Elusive (R3P)2MF2 (M = Pd, Pt) ComplexesQ44643151
The total synthesis of (+)-dragmacidin F.Q45005378
Palladium-catalyzed cyclization/carboalkoxylation of alkenyl indolesQ45021310
Selective Pd-catalyzed oxidative coupling of anilides with olefins through C-H bond activation at room temperatureQ45712253
Pd(II)-catalyzed amination of C-H bonds using single-electron or two-electron oxidants.Q45927948
Direct imidation to construct 1H-benzo[d]imidazole through Pd(II)-catalyzed C-H activation promoted by thiourea.Q45955395
Total synthesis of (+/-)-rhazinal using novel palladium-catalyzed cyclizationsQ46059926
Pd(II)-catalyzed hydroxyl-directed C-H activation/C-O cyclization: expedient construction of dihydrobenzofuransQ46180672
Oxidative Pd(II)-catalyzed C-H bond amination to carbazole at ambient temperatureQ46254563
Synthesis of 1,2- and 1,3-dicarboxylic acids via Pd(II)-catalyzed carboxylation of aryl and vinyl C-H bondsQ46333063
Synthesis of beta-, gamma-, and delta-lactams via Pd(II)-catalyzed C-H activation reactionsQ46333074
Synthesis of indolines and tetrahydroisoquinolines from arylethylamines by Pd(II)-catalyzed C-H activation reactionsQ46485952
Intramolecular Pd(II)-catalyzed oxidative biaryl synthesis under air: reaction development and scopeQ46547881
Palladium-catalyzed intermolecular aerobic oxidative amination of terminal alkenes: efficient synthesis of linear allylamine derivativesQ46592233
Highly regioselective arylation of sp3 C-H bonds catalyzed by palladium acetateQ46712613
Computational study of the mechanism of cyclometalation by palladium acetateQ46733183
Catalytic direct arylation with aryl chlorides, bromides, and iodides: intramolecular studies leading to new intermolecular reactionsQ46887001
One-pot synthesis of carbazoles by palladium-catalyzed N-arylation and oxidative coupling.Q46922738
Xenon difluoride induced aryl iodide reductive elimination: a simple access to difluoropalladium(II) complexesQ48541382
P433issue12
P304page(s)1778-1791
P577publication date2012-05-25
P1433published inSynthesisQ929920
P1476titleHeterocycle Formation via Palladium-Catalyzed C-H Functionalization
P478volume44

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