miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes.

scientific article

miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1020145005
P356DOI10.1038/ONC.2015.69
P698PubMed publication ID25798844

P50authorWinston HideQ37383962
Minh T N LeQ83490175
P2093author name stringJ Lieberman
M P Thomas
F Petrocca
S M Tan
G Altschuler
R Perdigão-Henriques
P2860cites workmiR-200 enhances mouse breast cancer cell colonization to form distant metastasesQ21091183
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Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteinsQ24299613
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ANP32E is a histone chaperone that removes H2A.Z from chromatinQ24323053
Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathwayQ24534439
Fast and effective prediction of microRNA/target duplexesQ24537313
MicroRNA targeting specificity in mammals: determinants beyond seed pairingQ24607724
The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2Q24608778
Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem CellsQ24610880
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIPQ24630900
MicroRNA-182-5p targets a network of genes involved in DNA repairQ24633326
Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAsQ24635151
Argonaute HITS-CLIP decodes microRNA-mRNA interaction mapsQ24645826
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2Q24646996
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cellsQ24649109
Circulating microRNAs as stable blood-based markers for cancer detectionQ24652098
The basics of epithelial-mesenchymal transitionQ24652992
MicroRNAs and their isomiRs function cooperatively to target common biological pathwaysQ27499590
Epithelial-mesenchymal transitions in tumour progressionQ27860487
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targetsQ27860792
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1Q27861068
The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cellsQ28143877
The formin-homology-domain-containing protein FHOD1 enhances cell migrationQ28187471
MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translationQ28281118
miR-200b as a prognostic factor in breast cancer targets multiple members of RAB familyQ28394618
Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signalingQ28477912
A proximal activator of transcription in epithelial-mesenchymal transitionQ28588516
miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumorsQ28742532
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Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosisQ29547575
MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancerQ29614237
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasionQ29616467
A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transitionQ29617690
Downregulation of miRNA-200c links breast cancer stem cells with normal stem cellsQ29619847
The formin-homology-domain-containing protein FHOD1 enhances cell migrationQ29999814
Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levelsQ30502172
Collective invasion in breast cancer requires a conserved basal epithelial programQ30573307
AILUN: reannotating gene expression data automaticallyQ31134851
miR-200b targets GATA-4 during cell growth and differentiationQ31813082
Serum miR-200c is a novel prognostic and metastasis-predictive biomarker in patients with colorectal cancerQ33654179
Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta.Q33721793
SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genesQ33867572
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathwayQ33926690
14-3-3 binding sites in the snail protein are essential for snail-mediated transcriptional repression and epithelial-mesenchymal differentiationQ33951080
miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1Q33996050
E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas.Q34088774
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogrammingQ34125369
Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasionQ34332451
Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumorQ34352016
MiR-200a regulates epithelial to mesenchymal transition-related gene expression and determines prognosis in colorectal cancer patientsQ34402921
miR-200b Targets Ets-1 and Is Down-regulated by Hypoxia to Induce Angiogenic Response of Endothelial CellsQ34503190
Transitions between epithelial and mesenchymal states in development and diseaseQ34761972
An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transitionQ34977307
Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stressQ35183034
Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonizationQ35204515
MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F.Q35697850
CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set.Q36103111
MicroRNA-200b is overexpressed in endometrial adenocarcinomas and enhances MMP2 activity by downregulating TIMP2 in human endometrial cancer cell line HEC-1A cellsQ36603067
Mapping the human miRNA interactome by CLASH reveals frequent noncanonical bindingQ36833119
A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cellsQ37171616
MicroRNA-200b regulates cyclin D1 expression and promotes S-phase entry by targeting RND3 in HeLa cellsQ38341911
Sequencing of captive target transcripts identifies the network of regulated genes and functions of primate-specific miR-522.Q38965159
MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanismsQ39389208
Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicityQ39408977
MicroRNA-200b reverses chemoresistance of docetaxel-resistant human lung adenocarcinoma cells by targeting E2F3.Q39433284
miR-200bc/429 cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP.Q39459142
MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1.Q39513672
miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancerQ39698184
MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts.Q39790978
MicroRNA-141 and -200a are involved in bone morphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5.Q39849364
TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switchQ39903519
An epistatic mini-circuitry between the transcription factors Snail and HNF4α controls liver stem cell and hepatocyte features exhorting opposite regulation on stemness-inhibiting microRNAs.Q42096394
miRNA and protein expression profiles of visceral adipose tissue reveal miR-141/YWHAG and miR-520e/RAB11A as two potential miRNA/protein target pairs associated with severe obesityQ47847761
The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer.Q48682005
HomoTarget: a new algorithm for prediction of microRNA targets in Homo sapiens.Q51297716
MiR-200b is involved in Tgf-β signaling to regulate mammalian palate development.Q51847951
A novel function of WAVE in lamellipodia: WAVE1 is required for stabilization of lamellipodial protrusions during cell spreadingQ81661004
MiR-429 is an independent prognostic factor in colorectal cancer and exerts its anti-apoptotic function by targeting SOX2Q85317023
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)158-172
P577publication date2015-03-23
P1433published inOncogeneQ1568657
P1476titlemiR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes
P478volume35

Reverse relations

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