Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Inhibits Major Histocompatibility Complex Class II Expression by Disrupting Enhanceosome Assembly through Binding with the Regulatory Factor X Complex

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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Inhibits Major Histocompatibility Complex Class II Expression by Disrupting Enhanceosome Assembly through Binding with the Regulatory Factor X Complex is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.03713-14
P8608Fatcat IDrelease_dy5c6syf7zbvhjwr3wejcaroha
P932PMC publication ID4442538
P698PubMed publication ID25740990

P50authorSubhash VermaQ57951657
Pravinkumar PurushothamanQ121298588
P2093author name stringNamrata Gupta
Qiliang Cai
Suhani Thakker
Shanthan Challa
P2860cites workA gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patientsQ22007941
RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiencyQ22009001
RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiencyQ24315739
RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdomQ24322587
Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cellsQ24527215
CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivationQ24551176
Associations and interactions between bare lymphocyte syndrome factorsQ24551773
Class II transactivator: mastering the art of major histocompatibility complex expressionQ24552298
Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complexQ24554195
Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-YQ24562002
The bare lymphocyte syndrome and the regulation of MHC expressionQ28204378
Genetic control of MHC class II expressionQ28216149
Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genesQ28263358
A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome)Q28301107
Expression of the three human major histocompatibility complex class II isotypes exhibits a differential dependence on the transcription factor RFXAPQ28511541
Comprehensive analysis of LANA interacting proteins essential for viral genome tethering and persistenceQ28533244
EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressorsQ33261811
Protein complexes associated with the Kaposi's sarcoma-associated herpesvirus-encoded LANA.Q33282107
Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen inhibits interferon (IFN) beta expression by competing with IFN regulatory factor-3 for binding to IFNB promoterQ33748042
Class II MHC genes: a model gene regulatory system with great biologic consequencesQ33805263
Characterization of monoclonal antibodies raised against the latent nuclear antigen of human herpesvirus 8Q33814510
Transcriptional scaffold: CIITA interacts with NF-Y, RFX, and CREB to cause stereospecific regulation of the class II major histocompatibility complex promoterQ33965074
Upregulation of Cellular Bcl-2 by the KSHV Encoded RTA Promotes Virion ProductionQ34013770
Monofunctional and polyfunctional CD8+ T cell responses to human herpesvirus 8 lytic and latency proteinsQ34189939
Assembly, transport, and function of MHC class II moleculesQ34328789
Conserved residues of the bare lymphocyte syndrome transcription factor RFXAP determine coordinate MHC class II expressionQ34474055
Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomesQ34593324
Function and regulation of class II transactivator in the immune systemQ34630279
IRF-4-mediated CIITA transcription is blocked by KSHV encoded LANA to inhibit MHC II presentationQ35034278
Viral inhibition of MHC class II antigen presentationQ35124245
Molecular Biology of Kaposi's Sarcoma-associated Herpesvirus and Related OncogenesisQ35124404
Structure and function of latency-associated nuclear antigenQ35124429
Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphomaQ35131811
Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirusQ35138059
CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complexQ35192842
Kaposi's Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Reduces Interleukin-8 Expression in Endothelial Cells and Impairs Neutrophil Chemotaxis by Degrading Nuclear p65Q35192868
Two B cell factors bind the HLA-DRA X box region and recognize different subsets of HLA class II promotersQ35793716
Modulation of Immune System by Kaposi’s Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion StrategiesQ35801076
Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease.Q35809792
Regulatory factor-X binding to mutant HLA-DRA promoter sequencesQ35918019
Sequences and factors: a guide to MHC class-II transcriptionQ36135151
Kaposi's sarcoma-associated herpesvirus inhibits expression and function of endothelial cell major histocompatibility complex class II via suppressor of cytokine signaling 3Q36155542
A novel antigen-processing-defective phenotype in major histocompatibility complex class II-positive CIITA transfectants is corrected by interferon-gammaQ36365569
Regulation of MHC class II expression, a unique regulatory system identified by the study of a primary immunodeficiency disease.Q36435823
Kaposi's sarcoma and its associated herpesvirusQ36487309
CIITA and Its Dual Roles in MHC Gene TranscriptionQ37405448
Implication of human herpesviruses in oncogenesis through immune evasion and supressionQ37522705
Cytolytic CD4 cells: Direct mediators in infectious disease and malignancyQ37710793
Herpesviruses Placating the Unwilling Host: Manipulation of the MHC Class II Antigen Presentation PathwayQ38046606
The Chromatin Landscape of Kaposi’s Sarcoma-Associated HerpesvirusQ38108700
Gammaherpesviruses and lymphoproliferative disordersQ38151190
Assembly of the RFX complex on the MHCII promoter: role of RFXAP and RFXB in relieving autoinhibition of RFX5.Q38288080
Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Recruits Topoisomerase IIβ for Latent DNA Replication of the Terminal RepeatsQ39320195
NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression.Q39366741
The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentationQ39591598
Major histocompatibility complex class II transcriptional platform: assembly of nuclear factor Y and regulatory factor X (RFX) on DNA requires RFX5 dimersQ39675159
The transcription factor RFX protects MHC class II genes against epigenetic silencing by DNA methylation.Q39822845
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mimics Epstein-Barr virus EBNA1 immune evasion through central repeat domain effects on protein processingQ40128647
In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma herpes virusQ40257446
The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA.Q40318272
Evolutionary conservation and characterization of the bare lymphocyte syndrome transcription factor RFX-B and its paralogue ANKRA2.Q40469893
Kaposi's sarcoma-associated herpesvirus-encoded viral IRF3 modulates major histocompatibility complex class II (MHC-II) antigen presentation through MHC-II transactivator-dependent and -independent mechanisms: implications for oncogenesisQ40529241
Lack of CIITA expression is central to the absence of antigen presentation functions of trophoblast cells and is caused by methylation of the IFN-gamma inducible promoter (PIV) of CIITA.Q40845871
Dissection of functional NF-Y-RFX cooperative interactions on the MHC class II Ea promoterQ40855305
CREB regulates MHC class II expression in a CIITA-dependent mannerQ40968178
Regulation of transcription of MHC class II genesQ41353021
Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 3 Inhibits Gamma Interferon and Major Histocompatibility Complex Class II ExpressionQ42059350
Solution Structure of the Heterotrimeric Complex between the Interaction Domains of RFX5 and RFXAP from the RFX Gene Regulatory ComplexQ42156320
Formation of the RFX gene regulatory complex induces folding of the interaction domain of RFXAP.Q43107227
Successful treatment of post-transplant Kaposi's sarcoma by reduction of immunosuppression.Q43974311
Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcomaQ45701411
Epigenetic silencing of the CIITA gene and posttranscriptional regulation of class II MHC genes in ocular melanoma cellsQ53887653
T-cell immunity to Kaposi sarcoma-associated herpesvirus: recognition of primary effusion lymphoma by LANA-specific CD4+ T cellsQ57259563
Purified X2 binding protein (X2BP) cooperatively binds the class II MHC X box region in the presence of purified RFX, the X box factor deficient in the bare lymphocyte syndromeQ71829451
The yeast two-hybrid assay to identify interacting proteinsQ73891707
A defect in the nuclear translocation of CIITA causes a form of type II bare lymphocyte syndromeQ74595039
Characterization of the RFX complex and the RFX5(L66A) mutant: implications for the regulation of MHC class II gene expressionQ79722457
Immune evasion by Kaposi's sarcoma-associated herpesvirusQ80212464
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectcoagulation factor x humanQ28859740
P304page(s)5536-5556
P577publication date2015-03-04
P1433published inJournal of VirologyQ1251128
P1476titleKaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Inhibits Major Histocompatibility Complex Class II Expression by Disrupting Enhanceosome Assembly through Binding with the Regulatory Factor X Complex
P478volume89

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cites work (P2860)
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Q90319823Molecular Biology of KSHV in Relation to HIV/AIDS-Associated Oncogenesis
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