IRF-4-mediated CIITA transcription is blocked by KSHV encoded LANA to inhibit MHC II presentation

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IRF-4-mediated CIITA transcription is blocked by KSHV encoded LANA to inhibit MHC II presentation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1003751
P932PMC publication ID3814934
P698PubMed publication ID24204280
P5875ResearchGate publication ID258350283

P50authorErle S RobertsonQ88590600
P2093author name stringJie Lu
Qiliang Cai
Shuvomoy Banerjee
Andrew D Hislop
Richard Dzeng
Amanda Cervini
P2860cites workRegulation of major histocompatibility complex class II genesQ24289448
Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytesQ24646670
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcomaQ28242984
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomasQ28299069
MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancersQ28306431
Negative regulation of Toll-like-receptor signaling by IRF-4.Q28587563
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's diseaseQ29619158
EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressorsQ33261811
IRF4 silencing inhibits Hodgkin lymphoma cell proliferation, survival and CCL5 secretionQ82651321
Interferon Regulatory Factor 4: Combinational Control of Lymphocyte DifferentiationQ84791007
Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 3 inhibits gamma interferon and major histocompatibility complex class II expressionQ42059350
Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes.Q42123661
Identification of distinct regions of 5' flanking DNA that mediate constitutive, IFN-gamma, STAT1, and TGF-beta-regulated expression of the class II transactivator gene.Q42453992
Kaposi sarcoma herpesvirus-encoded vFLIP and vIRF1 regulate antigen presentation in lymphatic endothelial cells.Q42502875
IRF-1 deficiency skews the differentiation of dendritic cells toward plasmacytoid and tolerogenic features.Q43871949
Differential regulation of class II MHC determinants on macrophages by IFN-gamma and IL-4.Q44938035
IRF-4 expression in the human myeloid lineage: up-regulation during dendritic cell differentiation and inhibition by 1alpha,25-dihydroxyvitamin D3.Q46437047
E47, IRF-4, and PU.1 synergize to induce B-cell-specific activation of the class II transactivator promoter III (CIITA-PIII).Q47225499
MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent.Q51115513
Kaposi's sarcoma-associated herpesvirus LANA hitches a ride on the chromosome.Q53621344
T-cell immunity to Kaposi sarcoma-associated herpesvirus: recognition of primary effusion lymphoma by LANA-specific CD4+ T cellsQ57259563
Regulation of Fc receptor for IgE (CD23) and class II MHC antigen expression on Burkitt's lymphoma cell lines by human IL-4 and IFN-gammaQ70051187
Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte functionQ71984887
The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cellsQ73184792
Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1Q74277987
Protein complexes associated with the Kaposi's sarcoma-associated herpesvirus-encoded LANA.Q33282107
p53 inhibition by the LANA protein of KSHV protects against cell deathQ33885642
Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA.Q33886675
HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphomaQ33889296
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activityQ33922095
Two distinct gamma interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, interferon regulatory factor 1, and transforming growth factor betaQ33957154
Epstein-Barr virus nuclear antigen 3C stabilizes Gemin3 to block p53-mediated apoptosisQ34102722
The RBP-Jκ binding sites within the RTA promoter regulate KSHV latent infection and cell proliferationQ34130213
Kaposi's sarcoma herpesvirus upregulates Aurora A expression to promote p53 phosphorylation and ubiquitylationQ34186981
Chromosome binding site of latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally replaced by histone H1Q34350776
Expression of the MHC class II transactivator (CIITA) type IV promoter in B lymphocytes and regulation by IFN-gammaQ34696238
The single RBP-Jkappa site within the LANA promoter is crucial for establishing Kaposi's sarcoma-associated herpesvirus latency during primary infectionQ35077558
Molecular Biology of Kaposi's Sarcoma-associated Herpesvirus and Related OncogenesisQ35124404
Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphomaQ35131811
The internal Kaposi's sarcoma-associated herpesvirus LANA regions exert a critical role on episome persistenceQ35140238
Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosisQ35175590
Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease.Q35809792
MHC class II transactivator (CIITA) expression is upregulated in multiple myeloma cells by IFN-gammaQ35842817
Kaposi's sarcoma-associated herpesvirus inhibits expression and function of endothelial cell major histocompatibility complex class II via suppressor of cytokine signaling 3Q36155542
The pIV-otal class II transactivator promoter regulates major histocompatibility complex class II expression in the thymusQ36369511
Selective abrogation of major histocompatibility complex class II expression on extrahematopoietic cells in mice lacking promoter IV of the class II transactivator gene.Q36369564
Both IFN-gamma and IL-4 induce MHC class II expression at the surface of mouse pro-B cellsQ36511198
IRF4 addiction in multiple myelomaQ36891060
IRF-4 functions as a tumor suppressor in early B-cell developmentQ36948612
The Kaposi's Sarcoma-associated Herpesvirus-encoded vIRF-3 Inhibits Cellular IRF-5Q37136785
Repression of IRF-4 target genes in human T cell leukemia virus-1 infectionQ38362324
The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentationQ39591598
Characterization of a novel human herpesvirus 8-encoded protein, vIRF-3, that shows homology to viral and cellular interferon regulatory factorsQ39593162
Kaposi's sarcoma-associated herpesvirus inhibits interleukin-4-mediated STAT6 phosphorylation to regulate apoptosis and maintain latencyQ39665994
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (KSHV) upregulates survivin expression in KSHV-Associated B-lymphoma cells and contributes to their proliferationQ39852047
In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma herpes virusQ40257446
Expression of Kaposi's sarcoma-associated herpesvirus-encoded K10/10.1 protein in tissues and its interaction with poly(A)-binding proteinQ40276880
CD4+ T-cell responses to Epstein-Barr virus (EBV) latent-cycle antigens and the recognition of EBV-transformed lymphoblastoid cell linesQ40441967
Kaposi's sarcoma-associated herpesvirus-encoded viral IRF3 modulates major histocompatibility complex class II (MHC-II) antigen presentation through MHC-II transactivator-dependent and -independent mechanisms: implications for oncogenesisQ40529241
Disruption of the B-cell specific transcriptional program in HHV-8 associated primary effusion lymphoma cell linesQ40669895
Quantitative control of MHC class II expression by the transactivator CIITA.Q41055792
Dissection of the interferon gamma-MHC class II signal transduction pathway reveals that type I and type II interferon systems share common signalling component(s)Q41520809
Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditionsQ42049779
Cytomegalovirus inhibits major histocompatibility class II expression on infected endothelial cellsQ42050049
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P304page(s)e1003751
P577publication date2013-10-31
P1433published inPLOS PathogensQ283209
P1476titleIRF-4-mediated CIITA transcription is blocked by KSHV encoded LANA to inhibit MHC II presentation
P478volume9

Reverse relations

cites work (P2860)
Q36646579Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS
Q64969424Direct Inhibition of IRF-Dependent Transcriptional Regulatory Mechanisms Associated With Disease.
Q45323918Ebola virus secreted glycoprotein decreases the anti-viral immunity of macrophages in early inflammatory responses
Q38817881Giving CD4+ T cells the slip: viral interference with MHC class II-restricted antigen processing and presentation.
Q64250362Impact of HVT Vaccination on Splenic miRNA Expression in Marek's Disease Virus Infections
Q49248446Impaired IFN-α-mediated signal in dendritic cells differentiates active from latent tuberculosis
Q64898709Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella.
Q89965497KSHV: Immune Modulation and Immunotherapy
Q38903379Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Inhibits Major Histocompatibility Complex Class II Expression by Disrupting Enhanceosome Assembly through Binding with the Regulatory Factor X Complex
Q34059252Kaposi's sarcoma-associated herpesvirus K3 and K5 ubiquitin E3 ligases have stage-specific immune evasion roles during lytic replication
Q38760916Major Histocompatibility Complex Class II HLA-DRα Is Downregulated by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Lytic Transactivator RTA and MARCH8.
Q40876736Repression of CIITA by the Epstein-Barr virus transcription factor Zta is independent of its dimerization and DNA binding
Q47570715TLRs/NLRs: Shaping the landscape of host immunity.
Q26747452The Modulation of Apoptotic Pathways by Gammaherpesviruses
Q26767186The Role of Gammaherpesviruses in Cancer Pathogenesis

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