Sonic Hedgehog inhibition as a strategy to augment radiosensitivity of hepatocellular carcinoma

scientific article

Sonic Hedgehog inhibition as a strategy to augment radiosensitivity of hepatocellular carcinoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/JGH.12931
P698PubMed publication ID25682950

P50authorAnn-Lii ChengQ38639483
Kai-Yuan TzenQ58875566
P2093author name stringJason Chia-Hsien Cheng
Chiao-Ling Tsai
Feng-Ming Hsu
Wei-Lin Liu
P2860cites workHedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancerQ27322930
Mutations affecting segment number and polarity in DrosophilaQ28273492
Hedgehog: functions and mechanismsQ29619190
Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathwayQ33567426
Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancerQ34022353
Hedgehog pathway inhibition radiosensitizes non-small cell lung cancersQ34094337
Radiation therapy for hepatocellular carcinoma: from palliation to cureQ34565716
Hedgehog signaling drives radioresistance and stroma-driven tumor repopulation in head and neck squamous cancersQ34620099
Polymeric nanoparticle-encapsulated hedgehog pathway inhibitor HPI-1 (NanoHHI) inhibits systemic metastases in an orthotopic model of human hepatocellular carcinomaQ35600888
Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumorsQ36959835
Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cellsQ36997036
Radiotherapy for hepatocellular carcinoma: an overview.Q37072524
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesisQ37110115
Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.Q37593483
Activation of the hedgehog-signaling pathway in human cancer and the clinical implicationsQ37638143
The Hedgehog's tale: developing strategies for targeting cancerQ37879912
Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cellsQ38281336
Sonic hedgehog signaling protects human hepatocellular carcinoma cells against ionizing radiation in an autocrine mannerQ39580882
A novel tripeptide, tyroserleutide, inhibits irradiation-induced invasiveness and metastasis of hepatocellular carcinoma in nude miceQ39711547
Sonic hedgehog promotes desmoplasia in pancreatic cancerQ39933626
Radiation-enhanced hepatocellular carcinoma cell invasion with MMP-9 expression through PI3K/Akt/NF-kappaB signal transduction pathway.Q40274284
Cyclopamine increases the cytotoxic effects of paclitaxel and radiation but not cisplatin and gemcitabine in Hedgehog expressing pancreatic cancer cellsQ40301291
Sonic Hedgehog signaling impairs ionizing radiation-induced checkpoint activation and induces genomic instabilityQ43248906
Dysregulation of the Hedgehog pathway in human hepatocarcinogenesisQ46843790
Hedgehog: an attribute to tumor regrowth after chemoradiotherapy and a target to improve radiation response.Q53589777
Activation of the hedgehog pathway in human hepatocellular carcinomas.Q54616323
Extrahepatic Metastases of Hepatocellular CarcinomaQ56172243
P433issue8
P304page(s)1317-1324
P577publication date2015-08-01
P1433published inJournal of Gastroenterology and HepatologyQ15764401
P1476titleSonic Hedgehog inhibition as a strategy to augment radiosensitivity of hepatocellular carcinoma
P478volume30

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cites work (P2860)
Q89967133Combination Therapy With Charged Particles and Molecular Targeting: A Promising Avenue to Overcome Radioresistance
Q28077738Combination treatment including targeted therapy for advanced hepatocellular carcinoma
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Q37362827Gli-1/PI3K/AKT/NF-kB pathway mediates resistance to radiation and is a target for reversion of responses in refractory acute myeloid leukemia cells
Q26764740Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment
Q47589566Hedgehog signalling in liver pathophysiology
Q39433923Implication of the Hedgehog pathway in hepatocellular carcinoma.
Q28391377Ionizing Radiation Exposure and Basal Cell Carcinoma Pathogenesis
Q27024032Neuropilins and liver
Q58758006Role of canonical Hedgehog signaling pathway in liver
Q90705657Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma
Q53414714Sonic Hedgehog, VACTERL, and Fanconi anemia: Pathogenetic connections and therapeutic implications.
Q51389967Sonic hedgehog signaling pathway mediates development of hepatocellular carcinoma.
Q64269302The Combination of Particle Irradiation With the Hedgehog Inhibitor GANT61 Differently Modulates the Radiosensitivity and Migration of Cancer Cells Compared to X-Ray Irradiation
Q92618438The expressions of Hedgehog and PI3K-AKT pathway components correlate with invasion and metastasis in hepatocellular carcinoma
Q52349162The hedgehog pathway in nonalcoholic fatty liver disease.

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