A Simple and Versatile Amide Directing Group for C-H Functionalizations

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A Simple and Versatile Amide Directing Group for C-H Functionalizations is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1002/ANIE.201600791
P932PMC publication ID5518755
P698PubMed publication ID27479708

P50authorJin-Quan YuQ27887829
P2093author name stringYan-Qiao Chen
Ru-Yi Zhu
Marcus E Farmer
P2860cites workHydroxyamination of aryl C-H bonds with N-hydroxycarbamate by synergistic Rh/Cu catalysis at room temperatureQ87155399
Palladium-Catalyzed Oxirane-Opening Reaction with Arenes via C-H Bond ActivationQ87211942
Facile Synthesis of Isoindolinones via Rh(III)-Catalyzed One-Pot Reaction of Benzamides, Ketones, and HydrazinesQ87218916
Rhodium(III)-catalyzed formal oxidative [4 + 1] cycloaddition of benzohydroxamic acids and α-diazoesters. A facile synthesis of functionalized benzolactamsQ87795748
Rh(III)-catalyzed selective coupling of N-methoxy-1H-indole-1-carboxamides and aryl boronic acidsQ88143863
Palladium-Catalyzed Ligand-Directed C−H Functionalization ReactionsQ29012891
Weak coordination as a powerful means for developing broadly useful C-H functionalization reactionsQ30410596
Ligand-enabled reactivity and selectivity in a synthetically versatile aryl C-H olefinationQ33444520
Rhodium-catalyzed C-C bond formation via heteroatom-directed C-H bond activationQ33645846
Ligand-enabled meta-C-H activation using a transient mediatorQ34466361
A predictably selective aliphatic C-H oxidation reaction for complex molecule synthesisQ34708270
Pd(II)-catalyzed enantioselective C-H activation of cyclopropanesQ35620535
Activation of remote meta-C-H bonds assisted by an end-on templateQ36067509
Ligand-enabled methylene C(sp3)-H bond activation with a Pd(II) catalystQ36405081
Direct transition metal-catalyzed functionalization of heteroaromatic compoundsQ36852312
A C-H bond activation-based catalytic approach to tetrasubstituted chiral allenesQ37031889
Versatile Pd(II)-catalyzed C-H activation/aryl-aryl coupling of benzoic and phenyl acetic acidsQ37071814
Pd(II)-catalyzed olefination of electron-deficient arenes using 2,6-dialkylpyridine ligandsQ37154137
Biotinylated Rh(III) complexes in engineered streptavidin for accelerated asymmetric C-H activationQ37286557
Palladium(II)-catalyzed C-H activation/C-C cross-coupling reactions: versatility and practicalityQ37294999
Cross-coupling of remote meta-C-H bonds directed by a U-shaped templateQ37372482
Ligand-accelerated ortho-C-H alkylation of arylcarboxylic acids using alkyl boron reagentsQ37427713
Conformation-induced remote meta-C-H activation of aminesQ37693606
Towards mild metal-catalyzed C-H bond activationQ37888484
Developing ligands for palladium(II)-catalyzed C-H functionalization: intimate dialogue between ligand and substrateQ38097103
Catalytic functionalization of C(sp2)-H and C(sp3)-H bonds by using bidentate directing groupsQ38150791
Palladium- and copper-catalyzed arylation of carbon-hydrogen bondsQ39818764
Ligand-enabled γ-C-H olefination and carbonylation: construction of β-quaternary carbon centersQ40430050
Ligand-enabled β-C-H arylation of α-amino acids using a simple and practical auxiliaryQ40701143
A coupling of benzamides and donor/acceptor diazo compounds to form γ-lactams via Rh(III)-catalyzed C-H activationQ40833722
Complementary regioselectivity in Rh(III)-catalyzed insertions of potassium vinyltrifluoroborate via C-H activation: preparation and use of 4-trifluoroboratotetrahydroisoquinolonesQ41035448
Rhodium(III)-catalyzed intramolecular hydroarylation, amidoarylation, and Heck-type reaction: three distinct pathways determined by an amide directing groupQ41850900
Ligand Design for Rh(III)-Catalyzed C-H Activation: An Unsymmetrical Cyclopentadienyl Enables a Regioselective Synthesis of DihydroisoquinolonesQ41937966
Overcoming the limitations of directed C-H functionalizations of heterocyclesQ42100068
Ligand-accelerated C-H activation reactions: evidence for a switch of mechanismQ42161197
Ligand-controlled C(sp³)-H arylation and olefination in synthesis of unnatural chiral α-amino acidsQ42920887
Rhodium(III)-catalyzed isoquinolone synthesis: the N-O bond as a handle for C-N bond formation and catalyst turnoverQ43078336
Isoquinoline synthesis via rhodium-catalyzed oxidative cross-coupling/cyclization of aryl aldimines and alkynesQ43286404
Pd-Catalyzed α-Selective C-H Functionalization of Olefins: En Route to 4-Imino-β-LactamsQ44009626
Synthesis of Phenanthridinones from N-methoxybenzamides and aryltriethoxysilanes through Rh(III)-catalyzed C-H and N-H bond activation.Q44545915
A highly selective catalytic method for the oxidative functionalization of C-H bondsQ44775636
Palladium-catalyzed oxygenation of unactivated sp3 C-H bondsQ45005364
A tunable class of chiral Cp ligands for enantioselective rhodium(III)-catalyzed C-H allylations of benzamidesQ45887386
Indole synthesis via rhodium catalyzed oxidative coupling of acetanilides and internal alkynes.Q45953534
Understanding reactivity and stereoselectivity in palladium-catalyzed diastereoselective sp3 C-H bond activation: intermediate characterization and computational studies.Q45964868
Pd(II)-catalyzed ortho trifluoromethylation of arenes and insights into the coordination mode of acidic amide directing groupsQ46075753
Carboxylate-assisted ruthenium-catalyzed alkyne annulations by C-H/Het-H bond functionalizationsQ46236096
Synthesis of 1,2- and 1,3-dicarboxylic acids via Pd(II)-catalyzed carboxylation of aryl and vinyl C-H bondsQ46333063
Synthesis of beta-, gamma-, and delta-lactams via Pd(II)-catalyzed C-H activation reactionsQ46333074
Divergent C-H functionalizations directed by sulfonamide pharmacophores: late-stage diversification as a tool for drug discoveryQ46631174
Highly regioselective arylation of sp3 C-H bonds catalyzed by palladium acetateQ46712613
Pd(II)-catalyzed cross-coupling of sp3 C-H Bonds with sp2 and sp3 boronic acids using air as the oxidantQ46745147
Palladium-catalyzed alkylation of aryl C-H bonds with sp3 organotin reagents using benzoquinone as a crucial promoterQ46877074
Mild rhodium(III)-catalyzed cyclization of amides with α,β-unsaturated aldehydes and ketones to azepinones: application to the synthesis of the homoprotoberberine frameworkQ46900762
Rhodium-catalyzed C-H functionalization-based approach to eight-membered lactamsQ47097950
Ruthenium-catalyzed C-H/N-O bond functionalization: green isoquinolone syntheses in water.Q50507961
Rhodium- and iridium-catalyzed oxidative coupling of benzoic acids with alkynes via regioselective C-H bond cleavage.Q50987030
The C-H activation/1,3-diyne strategy: highly selective direct synthesis of diverse bisheterocycles by Rh(III) catalysis.Q51070590
Rh(III)-catalyzed C-H activation/cyclization of indoles and pyrroles: divergent synthesis of heterocycles.Q51073380
Asymmetric synthesis of isoindolones by chiral cyclopentadienyl-rhodium(III)-catalyzed C-H functionalizations.Q51075513
Rhodium-catalyzed C-H alkynylation of arenes at room temperature.Q51112612
Rhodium(III)-catalyzed intramolecular annulation through C-H activation: total synthesis of (±)-antofine, (±)-septicine, (±)-tylophorine, and rosettacin.Q51331246
Chiral Cp-rhodium(III)-catalyzed asymmetric hydroarylations of 1,1-disubstituted alkenes.Q51768527
Rhodium(III)-catalyzed C-H activation/annulation with vinyl esters as an acetylene equivalent.Q52839005
Palladium-Catalyzed Deaminative Phenanthridinone Synthesis from Aniline via C-H Bond Activation.Q52874483
Tunable arylative cyclization of 1,6-enynes triggered by rhodium(III)-catalyzed C-H activation.Q53009466
Chiral cyclopentadienyl ligands as stereocontrolling element in asymmetric C-H functionalization.Q53108682
Synthesis of isoindolinones via palladium-catalyzed C-H activation of N-methoxybenzamides.Q53208539
Strain-promoted oxidative annulation of arynes and cyclooctynes with benzamides: palladium-catalyzed C-H/N-H activation for the synthesis of N-heterocycles.Q53427306
Ligand-controlled regiodivergent pathways of rhodium(III)-catalyzed dihydroisoquinolone synthesis: experimental and computational studies of different cyclopentadienyl ligands.Q54035463
Room-temperature synthesis of trisubstituted allenylsilanes via regioselective C-H functionalization.Q54618895
One-Pot Formation of CC and CN Bonds through Palladium-Catalyzed Dual CH Activation: Synthesis of PhenanthridinonesQ57614639
Palladium-Catalyzed Alkoxylation ofN-Methoxybenzamides via Direct sp2C−H Bond ActivationQ57614658
Rh(iii)-Catalyzed intramolecular redox-neutral cyclization of alkenes via C–H activationQ57657148
Mild Rh(III)-Catalyzed C–H Activation and Annulation with Alkyne MIDA Boronates: Short, Efficient Synthesis of Heterocyclic Boronic Acid DerivativesQ57657268
Mild Rhodium(III)-Catalyzed C-H Activation and Intermolecular Annulation with AllenesQ57657269
Rh[III]-Catalyzed Direct C–H Amination Using N-Chloroamines at Room TemperatureQ57657274
Rh(III)-Catalyzed Directed C−H Olefination Using an Oxidizing Directing Group: Mild, Efficient, and VersatileQ57657367
Palladium-Catalyzed Methylation and Arylation of sp2and sp3C−H Bonds in Simple Carboxylic AcidsQ59350168
New Heteroannulation Reactions ofN-Alkoxybenzamides by Pd(II) Catalyzed C–H ActivationQ59569720
Palladium-catalyzed alkylation of sp2 and sp3 C-H bonds with methylboroxine and alkylboronic acids: two distinct C-H activation pathwaysQ79141317
Molecular recognition in the selective oxygenation of saturated C-H bonds by a dimanganese catalystQ79816001
Pd(II)-catalyzed enantioselective activation of C(sp2)-H and C(sp3)-H bonds using monoprotected amino acids as chiral ligandsQ81289986
Pd-catalyzed stereoselective oxidation of methyl groups by inexpensive oxidants under mild conditions: a dual role for carboxylic anhydrides in catalytic C--H bond oxidationQ81399579
Palladium-catalyzed asymmetric iodination of unactivated C-H bonds under mild conditionsQ81437346
Ruthenium-catalyzed oxidative C-H bond olefination of N-methoxybenzamides using an oxidizing directing groupQ83274832
Pd-catalysed synthesis of isoquinolinones and analogues via C-H and N-H bonds double activationQ83446891
Catalytic dehydrogenative cross-coupling: forming carbon-carbon bonds by oxidizing two carbon-hydrogen bondsQ83579479
Rhodium(III)-catalyzed heterocycle synthesis using an internal oxidant: improved reactivity and mechanistic studiesQ83754838
Highly selective mild stepwise allylation of N-methoxybenzamides with allenesQ84232963
Synthesis of phenanthridinones from N-methoxybenzamides and arenes by multiple palladium-catalyzed C-H activation steps at room temperatureQ84879798
Ruthenium-catalyzed isoquinolone synthesis through C-H activation using an oxidizing directing groupQ85010530
Palladium-catalyzed cyclization of benzamides with arynes: application to the synthesis of phenaglydon and N-methylcrinasiadineQ85215162
Rhodium(III)-catalyzed oxidative C-H coupling of N-methoxybenzamides with aryl boronic acids: one-pot synthesis of phenanthridinonesQ85311724
Rh-catalyzed oxidizing group-directed ortho C-H vinylation of arenes by vinylstannanesQ85454437
Rhodium(III)-catalyzed C-H/C-C activation sequence: vinylcyclopropanes as versatile synthons in direct C-H allylation reactionsQ85935893
Rh(III)-catalyzed oxidative C-H bond arylation with hydroquinones: sustainable synthesis of dibenzo[b,d]pyran-6-ones and benzo[d]naphtho[1,2-b]pyran-6-onesQ86035173
One-pot cascade synthesis of N-methoxyisoquinolinediones via Rh(III)-catalyzed carbenoid insertion C-H activation/cyclizationQ86035785
Mild rhodium(III)-catalyzed C-H allylation with 4-vinyl-1,3-dioxolan-2-ones: direct and stereoselective synthesis of (E)-allylic alcoholsQ86087833
Ruthenium(II)-Catalyzed C-H Functionalizations with Allenes: Versatile Allenylations and AllylationsQ86173271
Efficient synthesis of hydroxyl isoindolones by a Pd-mediated C-H activation/annulation reactionQ87075409
P433issue36
P407language of work or nameEnglishQ1860
P304page(s)10578-10599
P577publication date2016-08-01
P1433published inAngewandte Chemie International EditionQ62023953
P1476titleA Simple and Versatile Amide Directing Group for C-H Functionalizations
P478volume55