| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Mark P A Luna-Vargas | |
| Jerry Edward Chipuk | |||
| P2860 | cites work | The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak | Q24292973 |
| Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization | Q24300125 | ||
| BH3 domains other than Bim and Bid can directly activate Bax/Bak | Q24305138 | ||
| BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents | Q24337209 | ||
| Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members | Q24648909 | ||
| Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design | Q27675512 | ||
| PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis | Q27675952 | ||
| ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets | Q27683708 | ||
| Structure-guided design of a selective BCL-X(L) inhibitor | Q27684453 | ||
| BH3-only proteins: a 20-year stock-take | Q28085220 | ||
| The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage | Q28115007 | ||
| Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak | Q28115212 | ||
| Minimalist Model Systems Reveal Similarities and Differences between Membrane Interaction Modes of MCL1 and BAK | Q28383717 | ||
| Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL | Q28504590 | ||
| BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress | Q28507379 | ||
| BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo | Q28539452 | ||
| BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation | Q28593563 | ||
| An inhibitor of Bcl-2 family proteins induces regression of solid tumours | Q29547595 | ||
| The landscape of somatic copy-number alteration across human cancers | Q29547648 | ||
| Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane | Q29616354 | ||
| ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor | Q29616727 | ||
| BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly | Q29617135 | ||
| Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics | Q29620467 | ||
| Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth | Q30300846 | ||
| Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors | Q30300847 | ||
| A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival | Q31100573 | ||
| Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer | Q33400716 | ||
| Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity | Q33418187 | ||
| The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis. | Q33782414 | ||
| Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo | Q33930057 | ||
| BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response | Q34182014 | ||
| BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice. | Q34249957 | ||
| Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome | Q34581367 | ||
| Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma. | Q34656632 | ||
| The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner | Q34685414 | ||
| BCL-2 family antagonists for cancer therapy | Q34891196 | ||
| Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL. | Q35170975 | ||
| Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax). | Q35543223 | ||
| The BCL-2 family reunion | Q35568029 | ||
| Structural biology of the Bcl-2 family of proteins | Q35680498 | ||
| Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy | Q35761070 | ||
| Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation | Q35880102 | ||
| Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis | Q35987570 | ||
| Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species | Q36018810 | ||
| An interconnected hierarchical model of cell death regulation by the BCL-2 family | Q36109186 | ||
| Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis | Q36288687 | ||
| Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis | Q36422392 | ||
| BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes | Q36478810 | ||
| Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). | Q36491873 | ||
| Gossypol-Induced Differentiation in Human Leukemia HL-60 Cells | Q36735281 | ||
| Direct and selective small-molecule activation of proapoptotic BAX | Q36741892 | ||
| The apoptosome: signalling platform of cell death | Q36766418 | ||
| Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane | Q36823954 | ||
| Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins | Q37068553 | ||
| Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis | Q37098808 | ||
| How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? | Q37100016 | ||
| Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation | Q37158414 | ||
| Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3 | Q37192687 | ||
| Evaluation of the BH3-only protein Puma as a direct Bak activator | Q37428715 | ||
| Cardiolipin Is Not Required for Bax-mediated Cytochrome c Release from Yeast Mitochondria | Q38349383 | ||
| Bcl-2 family of proteins as drug targets for cancer chemotherapy: the long way of BH3 mimetics from bench to bedside. | Q38529057 | ||
| The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane | Q38668186 | ||
| ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia | Q38949201 | ||
| Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAF(V600E) inhibition and can be targeted to reduce resistance. | Q39017332 | ||
| Pan-BH3 mimetic S1 exhibits broad-spectrum antitumour effects by cooperation between Bax and Bak. | Q39171337 | ||
| A unified model of mammalian BCL-2 protein family interactions at the mitochondria. | Q39292731 | ||
| Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming. | Q39689532 | ||
| Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737. | Q39860032 | ||
| Novel therapy of prostate cancer employing a combination of viral-based immunotherapy and a small molecule BH3 mimetic | Q40437589 | ||
| cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities. | Q40757128 | ||
| BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. | Q40886681 | ||
| ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells | Q42094231 | ||
| Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis. | Q43099640 | ||
| Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane | Q43184244 | ||
| Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria. | Q46002867 | ||
| Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program | Q46540822 | ||
| Contributions to Bax insertion and oligomerization of lipids of the mitochondrial outer membrane | Q46765170 | ||
| Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes | Q46847162 | ||
| Bax and Bcl-xL exert their regulation on different sites of the ceramide channel. | Q53380872 | ||
| [BH3 mimetics as a strategy to complement anticancer therapies] | Q60521041 | ||
| A CRAC-like motif in BAX sequence: Relationship with protein insertion and pore activity in liposomes | Q61192744 | ||
| Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2 | Q80208985 | ||
| Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax | Q86828903 | ||
| P433 | issue | 12 | |
| P304 | page(s) | 906-917 | |
| P577 | publication date | 2016-08-04 | |
| P1433 | published in | Trends in Cell Biology | Q1573994 |
| P1476 | title | Physiological and Pharmacological Control of BAK, BAX, and Beyond | |
| P478 | volume | 26 |
| Q102063580 | A small natural molecule CADPE kills residual colorectal cancer cells by inhibiting key transcription factors and translation initiation factors |
| Q90262608 | BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis |
| Q64100869 | Bax Targeted by miR-29a Regulates Chondrocyte Apoptosis in Osteoarthritis |
| Q47265377 | Biological Implications of Differential Expression of Mitochondrial-Shaping Proteins in Parkinson's Disease. |
| Q47408673 | CHO-Omics Review: The Impact of Current and Emerging Technologies on Chinese Hamster Ovary Based Bioproduction |
| Q36185176 | Combined bortezomib-based chemotherapy and p53 gene therapy using hollow mesoporous silica nanospheres for p53 mutant non-small cell lung cancer treatment. |
| Q58737147 | Contribution of BH3-domain and Transmembrane-domain to the Activity and Interaction of the Pore-forming Bcl-2 Proteins Bok, Bak, and Bax |
| Q47670493 | Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. |
| Q64979318 | Effects of Intestinal Microbial⁻Elaborated Butyrate on Oncogenic Signaling Pathways. |
| Q41777022 | Human colorectal cancer cells induce vascular smooth muscle cell apoptosis in an exocrine manner |
| Q90654712 | Intercalating the Role of MicroRNAs in Cancer: As Enemy or Protector |
| Q58582108 | MDM2 and Mitochondrial Function: One Complex Intersection |
| Q92712275 | Metabolomics Reveals that Cysteine Metabolism Plays a Role in Celastrol-Induced Mitochondrial Apoptosis in HL-60 and NB-4 Cells |
| Q46383293 | Metal chelator TPEN selectively induces apoptosis in K562 cells through reactive oxygen species signaling mechanism: implications for chronic myeloid leukemia |
| Q39084933 | Mitochondrial dynamics as regulators of cancer biology |
| Q47843948 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. |
| Q47689197 | Physiological functions of non-apoptotic caspase activity in the nervous system |
| Q90262750 | Poly-L-Arginine Induces Apoptosis of NCI-H292 Cells via ERK1/2 Signaling Pathway |
| Q55476988 | Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity. |
| Q39452441 | Progress in targeting the BCL-2 family of proteins. |
| Q46247597 | Protective Effects of Hesperidin (Citrus Flavonone) on High Glucose Induced Oxidative Stress and Apoptosis in a Cellular Model for Diabetic Retinopathy |
| Q64992426 | Protein phosphatase 2A activation mechanism contributes to JS-K induced caspase-dependent apoptosis in human hepatocellular carcinoma cells. |
| Q48496566 | Pterostilbene Attenuates Early Brain Injury Following Subarachnoid Hemorrhage via Inhibition of the NLRP3 Inflammasome and Nox2-Related Oxidative Stress |
| Q55244233 | Pterostilbene attenuates acute kidney injury in septic mice. |
| Q51347935 | Reduced risk of apoptosis: mechanisms of stress responses. |
| Q54978638 | Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK. |
| Q39449103 | Senescent cells: an emerging target for diseases of ageing |
| Q41243369 | Sulforaphane Induced Apoptosis via Promotion of Mitochondrial Fusion and ERK1/2-Mediated 26S Proteasome Degradation of Novel Pro-survival Bim and Upregulation of Bax in Human Non-Small Cell Lung Cancer Cells |
| Q55437410 | The coordinated effects of Apatinib and Tripterine on the proliferation, invasiveness and apoptosis of human hepatoma Hep3B cells. |
| Q52728387 | The cucurbitacins D, E, and I from Ecballium elaterium (L.) upregulate the LC3 gene and induce cell-cycle arrest in human gastric cancer cell line AGS. |
| Q41862581 | The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family |
| Q106926345 | WITHDRAWN: Mechanisms of the direct effects of oil-related contaminants on ovarian cells |
| Q48251216 | β-Ecdysterone protects SH-SY5Y cells against β-amyloid-induced apoptosis via c-Jun N-terminal kinase- and Akt-associated complementary pathways. |
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