SYK interaction with ITGβ4 suppressed by Epstein-Barr virus LMP2A modulates migration and invasion of nasopharyngeal carcinoma cells

scientific article published on 22 December 2014

SYK interaction with ITGβ4 suppressed by Epstein-Barr virus LMP2A modulates migration and invasion of nasopharyngeal carcinoma cells is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1006352729
P356DOI10.1038/ONC.2014.380
P698PubMed publication ID25531330
P5875ResearchGate publication ID269934028

P50authorLiudmila MatskovaQ30225119
P2093author name stringZ Zhang
T Pawson
W Zhao
M Werner
F Chen
X Zhou
F Tian
X Xiao
N Yu
B Hou
G Gish
I Ernberg
I Ignatyev
L-S Z Rathje
P2860cites workNasopharyngeal carcinomaQ21093175
The Syk tyrosine kinase suppresses malignant growth of human breast cancer cellsQ24290151
ARRDC3 suppresses breast cancer progression by negatively regulating integrin beta4Q24337712
Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinasesQ24515076
Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomesQ24598414
Integrin ligands at a glanceQ24600618
Shiga Toxin Increases Formation of Clathrin-Coated Pits through Syk KinaseQ27325579
Structure and function of hemidesmosomes: more than simple adhesion complexesQ33592752
Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinomaQ33598586
PY motifs of Epstein-Barr virus LMP2A regulate protein stability and phosphorylation of LMP2A-associated proteinsQ33842129
C-terminal domain of the Epstein-Barr virus LMP2A membrane protein contains a clustering signalQ33849076
Epstein-Barr virus latent membrane protein 2B (LMP2B) co-localizes with LMP2A in perinuclear regions in transiently transfected cellsQ34124495
Epstein-Barr-virus-encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasisQ34228703
SHP2 Mediates the Localized Activation of Fyn Downstream of the α6β4 Integrin To Promote Carcinoma InvasionQ34290934
Enrichment of stem-like cell population comprises transformation ability of Epstein-Barr virus latent membrane protein 2A for non-transformed cellsQ34633351
Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrapQ34780846
Role of β4 integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migrationQ35249284
Involvement of alpha6beta4 integrin in the mechanisms that regulate breast cancer progressionQ35749387
Epstein-Barr virus latent membrane protein-2A induces ITAM/Syk- and Akt-dependent epithelial migration through αv-integrin membrane translocationQ36276627
Tetraspanin CD151 plays a key role in skin squamous cell carcinoma.Q36350751
Integrin trafficking and the control of cell migrationQ36381482
Proteolytic processing of endogenous and recombinant beta 4 integrin subunitQ36531714
β4 Integrin signaling induces expansion of prostate tumor progenitorsQ36580342
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins.Q36632458
Molecular Characterization of the Murine SYK Protein Tyrosine Kinase cDNA, Transcripts and ProteinQ36690157
Consistent transcription of the Epstein-Barr virus LMP2 gene in nasopharyngeal carcinoma.Q36697762
Targeting integrin beta4 for cancer and anti-angiogenic therapyQ36932840
A key tyrosine (Y1494) in the beta4 integrin regulates multiple signaling pathways important for tumor development and progressionQ36982557
Ultrastructural localization of integrin subunits beta4 and alpha3 within the migrating epithelial tongue of in vivo human woundsQ37066087
Regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transitionQ37248197
Protein tyrosine kinase, syk: a key player in phagocytic cellsQ37362792
Dynamic regulation of the structure and functions of integrin adhesionsQ37425436
Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomesQ37732243
Role of α6β4 integrin in cell motility, invasion and metastasis of mammary tumorsQ37824482
Genome-wide identification of Epstein-Barr virus-driven promoter methylation profiles of human genes in gastric cancer cellsQ38495924
Migration inhibition of mammary epithelial cells by Syk is blocked in the presence of DDR1 receptorsQ39557228
Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt.Q39585482
Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinomaQ39865449
Tropomyosin assembly intermediates in the control of microfilament system turnover.Q39944767
Intrinsic signaling functions of the beta4 integrin intracellular domainQ40091012
The Shb signalling scaffold binds to and regulates constitutive signals from the Epstein-Barr virus LMP2A membrane proteinQ40169132
The beta 4 subunit cytoplasmic domain mediates the interaction of alpha 6 beta 4 integrin with the cytoskeleton of hemidesmosomesQ40241664
Syk tyrosine kinase mediates Epstein-Barr virus latent membrane protein 2A-induced cell migration in epithelial cellsQ40326039
Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesisQ40345158
Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrinQ40439809
The Epstein-Barr virus-encoded LMP2A and LMP2B proteins promote epithelial cell spreading and motility.Q40471301
Progressive loss of Syk and abnormal proliferation in breast cancer cellsQ40502712
The Epstein-Barr virus encoded latent membrane protein 2A augments signaling from latent membrane protein 1.Q40771232
Downregulation of hemidesmosomal proteins in nasopharyngeal carcinoma cells.Q40829606
Ligand-independent role of the beta 4 integrin subunit in the formation of hemidesmosomes.Q41040267
A function for the integrin alpha6beta4 in the invasive properties of colorectal carcinoma cells.Q41158782
Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. A possible signaling role for the Syk tyrosine kinase.Q41326678
Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.Q41762995
Critical role of S1PR1 and integrin β4 in HGF/c-Met-mediated increases in vascular integrityQ42049311
Two different mutations in the cytoplasmic domain of the integrin beta 4 subunit in nonlethal forms of epidermolysis bullosa prevent interaction of beta 4 with plectin.Q43910774
Expression of Epstein-Barr virus (EBV)-encoded latent membrane proteins and STAT3 activation in nasopharyngeal carcinomaQ45411309
Expression of the Epstein-Barr virus (EBV)-encoded latent membrane protein 2A (LMP2A) in EBV-associated nasopharyngeal carcinomaQ45640598
Epstein-Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR.Q45738898
The immunoreceptor tyrosine-based activation motif of Epstein-Barr virus LMP2A is essential for blocking BCR-mediated signal transductionQ45760793
Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis.Q52572763
Ca2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophilsQ59054568
Proteolytic cleavage of the integrin beta 4 subunitQ72401020
Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3Q72808954
Signaling by adhesion in human neutrophils: activation of the p72syk tyrosine kinase and formation of protein complexes containing p72syk and Src family kinases in neutrophils spreading over fibrinogenQ73064447
Differential gene expression in nasopharyngeal carcinoma cellsQ74184641
Clinical significance of elevated spleen tyrosine kinase expression in nasopharyngeal carcinomaQ83354085
P433issue34
P407language of work or nameEnglishQ1860
P921main subjectEpstein–Barr virusQ6900
P304page(s)4491-4499
P577publication date2014-12-22
P1433published inOncogeneQ1568657
P1476titleSYK interaction with ITGβ4 suppressed by Epstein-Barr virus LMP2A modulates migration and invasion of nasopharyngeal carcinoma cells
P478volume34