Metabolic activation of pyrrolizidine alkaloids leading to phototoxicity and photogenotoxicity in human HaCaT keratinocytes.

scientific article

Metabolic activation of pyrrolizidine alkaloids leading to phototoxicity and photogenotoxicity in human HaCaT keratinocytes. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1080/10590501.2014.969980
P698PubMed publication ID25436474
P5875ResearchGate publication ID269115714

P50authorJun-Jie YinQ83991633
P2093author name stringMeng Li
Peter P Fu
William H Tolleson
Chia-Chi Wang
Shuguang Wang
Qingsu Xia
Yuewei Zhao
P2860cites workNormal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell lineQ29547520
Metabolic activation of the tumorigenic pyrrolizidine alkaloid, riddelliine, leading to DNA adduct formation in vivoQ31915820
Oxidative biochemical markers; clues to understanding aging in long-lived speciesQ34214189
Plant sources of hepatotoxic pyrrolizidine alkaloidsQ34276029
Pyrrolizidine alkaloids--genotoxicity, metabolism enzymes, metabolic activation, and mechanismsQ34312030
Phototoxicity of nano titanium dioxides in HaCaT keratinocytes--generation of reactive oxygen species and cell damageQ36123915
UVA light-induced DNA cleavage by selected polycyclic aromatic hydrocarbonsQ37267417
Phototoxicity of zinc oxide nanoparticles in HaCaT keratinocytes-generation of oxidative DNA damage during UVA and visible light irradiation.Q39124616
Malignant neoplasms in rats fed lasiocarpineQ40133654
Reactive oxygen-mediated protein oxidation in aging and diseaseQ41485816
A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolcarbocyanine iodide (JC-1).Q41513463
Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analoguesQ42258505
Effects of the differentiated keratinocyte phenotype on expression levels of CYP1-4 family genes in human skin cellsQ42486923
ESR detection of 1O2 reveals enhanced redox activity in illuminated cell culturesQ42819920
High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of pyrrolizidine alkaloid-derived DNA adducts in vitro and in vivoQ43193170
Human Liver Microsomal Metabolism and DNA Adduct Formation of the Tumorigenic Pyrrolizidine Alkaloid, RiddelliineQ44401798
Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F(1) miceQ44411096
Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliineQ44633455
[17O]oxygen hyperfine structure for the hydroxyl and superoxide radical adducts of the spin traps DMPO, PBN and 4-POBN.Q44694231
Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii hook.Q44896639
Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liverQ45157659
Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloidQ45223262
Photodecomposition of retinyl palmitate in ethanol by UVA light-formation of photodecomposition products, reactive oxygen species, and lipid peroxidesQ45273158
Pyrrolizidine alkaloid-derived DNA adducts as a common biological biomarker of pyrrolizidine alkaloid-induced tumorigenicityQ45824220
Involvement of cytochrome P450 3A in the metabolism and covalent binding of 14C-monocrotaline in rat liver microsomes.Q45979562
Dehydromonocrotaline induces cyclosporine A-insensitive mitochondrial permeability transition/cytochrome c release.Q46088772
Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrineQ46658477
Role of phagocyte oxidase in UVA-induced oxidative stress and apoptosis in keratinocytesQ46665443
Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine.Q46852855
The roles of CYP3A and CYP2B isoforms in hepatic bioactivation and detoxification of the pyrrolizidine alkaloid senecionine in sheep and hamstersQ47674325
Photo-irradiation of Aloe vera by UVA--formation of free radicals, singlet oxygen, superoxide, and induction of lipid peroxidation.Q53506084
New method of detecting singlet oxygen productionQ59064089
P433issue4
P921main subjectPhototoxicityQ2088972
pyrrolizidine alkaloidQ75005794
P304page(s)362-384
P577publication date2014-01-01
P1433published inJournal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology ReviewsQ15724521
P1476titleMetabolic activation of pyrrolizidine alkaloids leading to phototoxicity and photogenotoxicity in human HaCaT keratinocytes
P478volume32

Reverse relations

cites work (P2860)
Q50559583Blood Pyrrole-Protein Adducts--A Biomarker of Pyrrolizidine Alkaloid-Induced Liver Injury in Humans.
Q50438002Immunoassay approach for diagnosis of exposure to pyrrolizidine alkaloids.
Q26801908Phototoxicity: Its Mechanism and Animal Alternative Test Methods
Q53112364The long persistence of pyrrolizidine alkaloid-derived DNA adducts in vivo: kinetic study following single and multiple exposures in male ICR mice.

Search more.