Aptamer and its applications in neurodegenerative diseases

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Aptamer and its applications in neurodegenerative diseases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00018-016-2345-4
P698PubMed publication ID27563707

P2093author name stringHui Yang
Jing Qu
Yuan Zheng
Yan Zheng
Jianliang Zhang
Shuqing Yu
P2860cites workCellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomersQ22251089
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Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease modelsQ24315670
A tenascin-C aptamer identified by tumor cell SELEX: systematic evolution of ligands by exponential enrichmentQ24618342
PrionsQ24633319
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Molecular Selection, Modification and Development of Therapeutic Oligonucleotide AptamersQ26765458
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Nucleic acid aptamers: research tools in disease diagnostics and therapeuticsQ26824321
Membrane Permeabilization by Oligomeric α-Synuclein: In Search of the MechanismQ27315907
Unique quadruplex structure and interaction of an RNA aptamer against bovine prion proteinQ27656952
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymeraseQ27860794
In vitro selection of RNA molecules that bind specific ligandsQ27861109
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Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model fliesQ28476061
Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer's Disease Cell ModelQ28550356
Fast, reversible interaction of prion protein with RNA aptamers containing specific sequence patternsQ29392099
Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selectionQ29617433
Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigenQ30739257
Aptamers: an emerging class of molecules that rival antibodies in diagnosticsQ30764345
Peptide aptamers: tools for biology and drug discoveryQ30764480
RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivityQ30879431
Characterization of 2'-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion.Q31151988
Bifunctional recombinant proteins in cancer therapy: cell penetrating peptide aptamers as inhibitors of growth factor signalingQ31166485
Short G-rich oligonucleotides as a potential therapeutic for Huntington's DiseaseQ33259103
Selection of aptamers for molecular recognition and characterization of cancer cellsQ33285855
SELEX--a (r)evolutionary method to generate high-affinity nucleic acid ligandsQ33290703
Advances in SELEX and application of aptamers in the central nervous systemQ33293314
Functional DNA-containing nanomaterials: cellular applications in biosensing, imaging, and targeted therapyQ33791768
DNA aptamer evolved by cell-SELEX for recognition of prostate cancerQ33793416
Automated selection of anti-protein aptamersQ33954658
An RNA motif that binds ATPQ34058538
LNA: a versatile tool for therapeutics and genomicsQ34175818
Selection of DNA aptamers that recognize α-synuclein oligomers using a competitive screening method.Q34303977
Comparison of different methods for generation of single-stranded DNA for SELEX processesQ34317021
RNA aptamers that bind L-arginine with sub-micromolar dissociation constants and high enantioselectivityQ38360485
Aptamer-conjugated polymeric nanoparticles for targeted cancer therapyQ38383216
Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics.Q38443249
Aptamer Oligonucleotides: Novel Potential Therapeutic Agents in Autoimmune DiseaseQ38494145
A Highlight of Recent Advances in Aptamer Technology and Its ApplicationQ38541697
NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synucleinQ38562137
Oxidative Modification and Its Implications for the Neurodegeneration of Parkinson's DiseaseQ38722255
Enhancing aptamer function and stability via in vitro selection using modified nucleic acidsQ38787655
3D Cell-SELEX: Development of RNA aptamers as molecular probes for PC-3 tumor cell line.Q38798663
PEI protected aptamer molecular probes for contrast-enhanced in vivo cancer imagingQ39307748
Aptamer-conjugated DNA icosahedral nanoparticles as a carrier of doxorubicin for cancer therapy.Q39511979
Aptamer-nanoparticle strip biosensor for sensitive detection of cancer cellsQ39776245
Self-crosslinked and reducible fusogenic peptides for intracellular delivery of siRNA.Q39975907
Aptamer:toxin conjugates that specifically target prostate tumor cellsQ40267091
Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA deliveryQ40390348
Clinical applications of nucleic acid aptamers in cancerQ42332603
Molecular recognition of small-cell lung cancer cells using aptamersQ42720667
Effects of charge density and hydrophobicity of poly(amido amine)s for non-viral gene deliveryQ42957790
Screening of DNA aptamer against mouse prion protein by competitive selectionQ43189229
Structural determinants of conformationally selective, prion-binding aptamers.Q44719244
Biomedicine. Parkinson's--divergent causes, convergent mechanisms.Q44904985
Extracellular potentials recording in intact taste epithelium by microelectrode array for a taste sensorQ44941927
Pegaptanib for neovascular age-related macular degenerationQ45206481
Uncovering the true prevalence of Huntington's diseaseQ45298664
Single particle characterization of iron-induced pore-forming alpha-synuclein oligomersQ46765690
Effect of the attention deficit/hyperactivity disorder drug atomoxetine on extracellular concentrations of norepinephrine and dopamine in several brain regions of the rat.Q46904762
Simultaneous tracking of drug molecules and carriers using aptamer-functionalized fluorescent superstable gold nanorod-carbon nanocapsules during thermo-chemotherapyQ48622833
Multifunctional quantum-dot-based siRNA delivery for HPV18 E6 gene silence and intracellular imagingQ50675322
Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration.Q50724125
Sodium dodecyl sulfate-modified carbon paste electrodes for selective determination of dopamine in the presence of ascorbic acid.Q51163851
Aptamers as therapeutics.Q51813594
Automated RNA selection.Q52230208
An ultrasensitive nanowire-transistor biosensor for detecting dopamine release from living PC12 cells under hypoxic stimulation.Q54763443
In vitro selection of DNA aptamers to anthrax spores with electrochemiluminescence detectionQ56902246
In vitro selection of dopamine RNA ligandsQ73561259
Bringing picomolar protein detection into proximityQ78021697
In vitro selection of high-affinity DNA ligands for human IgE using capillary electrophoresisQ80554058
A novel label-free electrochemical aptasensor based on graphene-polyaniline composite film for dopamine determinationQ95805563
Remyelination induced by a DNA aptamer in a mouse model of multiple sclerosis.Q34326301
Epidemiology. Paths from pesticides to Parkinson'sQ34364387
Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2.Q34375960
Targeting the variable surface of African trypanosomes with variant surface glycoprotein-specific, serum-stable RNA aptamers.Q34473279
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular diseaseQ34499843
Dopamine and the diseased brainQ34513611
Recent trends in SELEX technique and its application to food safety monitoringQ34552324
Nanoparticles in medicine: therapeutic applications and developmentsQ34655287
Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms.Q35012627
Aptamers evolved from live cells as effective molecular probes for cancer studyQ35033059
Current approaches in SELEX: An update to aptamer selection technology.Q35566463
The formulation of aptamer-coated paclitaxel-polylactide nanoconjugates and their targeting to cancer cellsQ35567561
Progress in selection and biomedical applications of aptamers.Q35635898
Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distributionQ35779820
Theranostic MUC-1 aptamer targeted gold coated superparamagnetic iron oxide nanoparticles for magnetic resonance imaging and photothermal therapy of colon cancer.Q35970606
Pegaptanib: in exudative age-related macular degenerationQ36201593
Screening of aptamers on microfluidic systems for clinical applicationsQ36239152
DNA Aptamer Based Nanodrugs: Molecular Engineering for EfficiencyQ36498635
Ion-dependent conformational switching by a DNA aptamer that induces remyelination in a mouse model of multiple sclerosis.Q36559199
Bioactive and nuclease-resistant L-DNA ligand of vasopressinQ36591985
Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway.Q36664193
Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding siteQ36728377
GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A.Q36777244
Complex target SELEX.Q37056570
Pegaptanib sodium treatment in neovascular age-related macular degeneration: clinical experience in GermanyQ37221529
Application of locked nucleic acids to improve aptamer in vivo stability and targeting functionQ37619467
α-Synuclein: membrane interactions and toxicity in Parkinson's diseaseQ37760521
Development of aptamer therapeuticsQ37773719
Applications of aptamers in nanodelivery systems in cancer, eye and inflammatory diseasesQ37815481
Aptamers: selection, modification and application to nervous system diseasesQ37916660
Single-stranded DNA (ssDNA) production in DNA aptamer generationQ37982285
Prion propagation, toxicity and degradationQ38021894
The application of aptamers in cancer research: an up-to-date reviewQ38087391
The remarkable conformational plasticity of alpha-synuclein: blessing or curse?Q38104514
Three-dimensional perfused cell cultureQ38159091
Are dopamine derivatives implicated in the pathogenesis of Parkinson's disease?Q38175706
Aptamers: problems, solutions and prospectsQ38181121
Aptamers as a replacement for antibodies in enzyme-linked immunosorbent assayQ38256321
Aptamers as promising molecular recognition elements for diagnostics and therapeutics in the central nervous systemQ38258163
In vitro Selection of DNA Aptamers to Glioblastoma Multiforme.Q38274697
Bioinformatic analysis of the contribution of primer sequences to aptamer structuresQ38289647
Use of magnetic beads in selection and detection of biotoxin aptamers by electrochemiluminescence and enzymatic methodsQ38292683
Tenascin-C aptamers are generated using tumor cells and purified proteinQ38296050
In vitro selection of RNA ligands to substance P.Q38296387
Myelin Basic Protein and a Multiple Sclerosis-related MBP-peptide Bind to Oligonucleotides.Q38304326
Cell-SELEX-based selection of aptamers that recognize distinct targets on metastatic colorectal cancer cells.Q38306874
Selection of DNA ligands for protein kinase C-delta.Q38308752
RNA aptamers selectively modulate protein recruitment to the cytoplasmic domain of beta-secretase BACE1 in vitroQ38310913
Cell type-specific delivery of siRNAs with aptamer-siRNA chimerasQ38311731
Extending the lifetime of anticoagulant oligodeoxynucleotide aptamers in bloodQ38311833
Anti-L-selectin aptamers: binding characteristics, pharmacokinetic parameters, and activity against an intravascular target in vivoQ38312416
Molecular recognition of amino acids by RNA aptamers: the evolution into an L-tyrosine binder of a dopamine-binding RNA motif.Q38312753
Characterization and application of a novel RNA aptamer against the mouse prion proteinQ38314743
DNA aptamers that bind to PrP(C) and not PrP(Sc) show sequence and structure specificityQ38316301
RNA aptamer-based electrochemical biosensor for selective and label-free analysis of dopamineQ38319549
Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug deliveryQ38333122
Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cellsQ38334788
In vivo Fluorescence Imaging of Tumors using Molecular Aptamers Generated by Cell‐SELEXQ38341267
Selection of aptamers for amyloid beta-protein, the causative agent of Alzheimer's disease.Q38342641
In vitro selection of DNA to chloroaromatics using magnetic microbead-based affinity separation and fluorescence detectionQ38346074
Mirror-design of L-oligonucleotide ligands binding to L-arginineQ38353220
P433issue4
P921main subjectneurodegenerationQ1755122
P304page(s)683-695
P577publication date2016-08-25
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleAptamer and its applications in neurodegenerative diseases
P478volume74

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cites work (P2860)
Q37679265Amyloid-beta immunotherapy: the hope for Alzheimer disease?
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Q92776477Exosomal DNA Aptamer Targeting α-Synuclein Aggregates Reduced Neuropathological Deficits in a Mouse Parkinson's Disease Model
Q48087924Fluorescence Sensing Using DNA Aptamers in Cancer Research and Clinical Diagnostics.
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Q88954180Novel DNA Aptamers for Parkinson's Disease Treatment Inhibit α-Synuclein Aggregation and Facilitate its Degradation
Q47104247Nucleic Acid Aptamers: Emerging Applications in Medical Imaging, Nanotechnology, Neurosciences, and Drug Delivery.
Q38288126Unraveling Prion Protein Interactions with Aptamers and Other PrP-Binding Nucleic Acids

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