A review of factors explaining variability in fentanyl pharmacokinetics; focus on implications for cancer patients

scientific article published on 12 September 2016

A review of factors explaining variability in fentanyl pharmacokinetics; focus on implications for cancer patients is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1111/BCP.13129
P932PMC publication ID5237702
P698PubMed publication ID27619152

P2093author name stringRon H J Mathijssen
Stijn L W Koolen
Carin C D van der Rijt
Maarten L Zandvliet
Evelien J M Kuip
P2860cites workThe Concise Guide to PHARMACOLOGY 2015/16: EnzymesQ28552567
The Concise Guide to PHARMACOLOGY 2015/16: TransportersQ28552572
The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligandsQ28603128
The Concise Guide to PHARMACOLOGY 2015/16: OverviewQ30488640
Breakthrough pain: definition, prevalence and characteristicsQ33435886
Clinical pharmacokinetics of transdermal opioids: focus on transdermal fentanylQ33834608
Transdermal fentanyl: an updated review of its pharmacological properties and therapeutic efficacy in chronic cancer pain controlQ34481299
The influence of sex on pharmacokineticsQ35049301
Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanilQ35092352
Absorption and tolerability of fentanyl buccal soluble film (FBSF) in patients with cancer in the presence of oral mucositisQ35221603
Support of the metabolic response to burn injuryQ35796326
Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrateQ35871326
Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrateQ35871331
Treatment with subcutaneous and transdermal fentanyl: results from a population pharmacokinetic study in cancer patients.Q36688467
Fentanyl for breakthrough pain: a systematic reviewQ37907299
Determining the optimal dose in the development of anticancer agentsQ38198948
A Systematic Review of Prospective Studies Reporting Adverse Events of Commonly Used Opioids for Cancer-Related Pain: A Call for the Use of Standardized Outcome Measures.Q38519237
Fentanyl pharmacokinetics is not dependent on hepatic uptake by organic anion-transporting polypeptide 1B1 in human beingsQ39182431
Formulations of fentanyl for the management of painQ39293912
Inter- and intra-individual variability in transdermal fentanyl absorption in cancer pain patients.Q39362437
Inter- and intraindividual variabilities in pharmacokinetics of fentanyl after repeated 72-hour transdermal applications in cancer pain patientsQ39364004
Transdermal fentanyl. A review of its pharmacological properties and therapeutic efficacy in pain controlQ39459785
Pharmacokinetics of fentanyl during constant rate i.v. infusion for the relief of pain after surgeryQ39541998
Clinical pharmacokinetics of fentanyl and its newer derivatives.Q40115663
Life-threatening coma and full-thickness sunburn in a patient treated with transdermal fentanyl patches: a case reportQ40279485
Case report: delirium due to a diltiazem-fentanyl CYP3A4 drug interactionQ42791386
A review of the use of fentanyl analgesia in the management of acute pain in adultsQ43070474
Fentanyl transdermal absorption linked to pharmacokinetic characteristics in patients undergoing palliative careQ43185208
Population pharmacokinetics of fentanyl in healthy volunteers.Q43673466
Opioid overdose in a patient using a fentanyl patch during treatment with a warming blanketQ43721196
Itraconazole-fentanyl interaction in a cancer patientQ44233589
Opioid-induced respiratory depression resulting from transdermal fentanyl-clarithromycin drug interaction in a patient with advanced COPD.Q44342955
Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4.Q44343799
The pharmacokinetics of transdermal fentanyl delivered with and without controlled heatQ44658602
Serum concentration of fentanyl during conversion from intravenous to transdermal administration to patients with chronic cancer painQ45759953
Transdermal fentanyl in cachectic cancer patients.Q46012125
Evaluation of diurnal variation in fentanyl clearanceQ46591983
Pharmacokinetics of fentanyl in the elderlyQ46733636
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expressionQ46906576
Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanylQ46911536
Pharmacokinetic interaction of intravenous fentanyl with ketoconazoleQ47752672
Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS studyQ47919321
Impact of CYP3A5*3 on plasma exposure and urinary excretion of fentanyl and norfentanyl in the early postsurgical periodQ47933153
Pharmacokinetics and dose proportionality of fentanyl sublingual spray: a single-dose 5-way crossover studyQ48015149
Impact of allergic rhinitis and its treatment on the pharmacokinetics of nasally administered fentanylQ48030393
Population pharmacokinetics of transdermal fentanyl in patients with cancer-related painQ48149163
Impact of CYP3A5 and ABCB1 gene polymorphisms on fentanyl pharmacokinetics and clinical responses in cancer patients undergoing conversion to a transdermal systemQ48192111
Active transport of fentanyl by the blood-brain barrier.Q48228612
Randomized 5-treatment crossover study to assess the effects of external heat on serum fentanyl concentrations during treatment with transdermal fentanyl systems.Q48235000
The population pharmacokinetics of fentanyl in patients undergoing living-donor liver transplantationQ48241556
Absorption of fentanyl from fentanyl buccal tablet in cancer patients with or without oral mucositis: a pilot studyQ48572563
Fentanyl clearance and volume of distribution are increased in patients with major burnsQ48606918
Possible fluconazole-fentanyl interaction-a case reportQ48692216
Assessing the impact of heat on the systemic delivery of fentanyl through the transdermal fentanyl delivery systemQ48892222
Breakthrough pain: characteristics and impact in patients with cancer pain.Q51089873
Impaired memory and behavioral performance with fentanyl at low plasma concentrations.Q51130059
Ritonavir's role in reducing fentanyl clearance and prolonging its half-life.Q51441513
The CYP 3A4 inhibitor itraconazole has no effect on the pharmacokinetics of i.v. fentanyl.Q51478388
Heat-related toxicity with the fentanyl transdermal patch.Q51487004
Perioperative pharmacokinetics of transdermal fentanyl in elderly and young adult patients.Q51491969
Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions.Q51536172
Fentanyl pharmacokinetics in patients undergoing renal transplantation.Q51539421
Transdermal fentanyl disposition in elderly subjects.Q51645730
Age and fentanyl pharmacokinetics.Q51857997
Fentanyl Pharmacokinetics in Awake VolunteersQ51872910
Pharmacokinetics of high-dose fentanyl. A study in patients undergoing cardiac surgery.Q51874913
Intravenous fentanyl kinetics.Q51875549
Epidemiology and Pattern of Care of Breakthrough Cancer Pain in a Longitudinal Sample of Cancer PatientsQ59649189
Pharmacokinetic and pharmacodynamic changes in the elderly. Clinical implicationsQ74798758
Management of cancer painQ77769507
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectpharmacokineticsQ323936
fentanylQ407541
P304page(s)294-313
P577publication date2016-10-29
P1433published inBritish Journal of Clinical PharmacologyQ176044
P1476titleA review of factors explaining variability in fentanyl pharmacokinetics; focus on implications for cancer patients
P478volume83

Reverse relations

cites work (P2860)
Q90184953Characterizing Fentanyl Variability Using Population Pharmacokinetics in Pediatric Burn Patients
Q90376886Does transdermal fentanyl work in patients with low BMI? Patient-reported outcomes of pain and percent pain relief in cancer patients on transdermal fentanyl
Q50052624Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial
Q55382249Effects of smoking and body mass index on the exposure of fentanyl in patients with cancer.
Q58118095Impact of CYP3A4*1G Polymorphism on Fentanyl Analgesia Assessed by Analgesia Nociception Index in Chinese Patients Undergoing Hysteroscopy
Q98892340Indian Society for Study of Pain, Cancer Pain Special Interest Group Guidelines on Pharmacological Management of Cancer Pain (Part I)
Q53681128Influence of aprepitant and localization of the patch on fentanyl exposure in patients with cancer using transdermal fentanyl.
Q53682973Is there a role for pharmacogenetics in the dosing of fentanyl?
Q64071994Metabolic Pathways and Potencies of New Fentanyl Analogs
Q90641478Minor contribution of cytochrome P450 3A activity on fentanyl exposure in palliative care cancer patients
Q47341348Not so patchy story of attempted suicide…leading to 24 hours of deep sleep and survival!
Q64891530Pain polymorphisms and opioids: An evidence based review.
Q59800576Pharmacokinetics of Sublingually Delivered Fentanyl in Head and Neck Cancer Patients Treated with Curatively Aimed Chemo or Bioradiotherapy
Q99725553Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients
Q98197851Safety, Tolerability, and Dose Proportionality of a Novel Transdermal Fentanyl Matrix Patch and Bioequivalence With a Matrix Fentanyl Patch: Two Phase 1 Single-Center Open-Label, Randomized Crossover Studies in Healthy Japanese Volunteers

Search more.