Quantitative determination of decitabine incorporation into DNA and its effect on mutation rates in human cancer cells

scientific article published on 26 August 2014

Quantitative determination of decitabine incorporation into DNA and its effect on mutation rates in human cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKU775
P932PMC publication ID4231731
P698PubMed publication ID25159616
P5875ResearchGate publication ID265057962

P50authorFrank LykoQ56168094
P2093author name stringMichael Lübbert
Günter Raddatz
Nadja Blagitko-Dorfs
Maria Rius
Christian Maercker
Simin Öz
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell linesQ28472733
Epigenetics in human disease and prospects for epigenetic therapyQ29547437
Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleuraQ33259359
5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapyQ34770609
Pharmacokinetics of decitabine administered as a 3-h infusion to patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).Q53547181
Decitabine triphosphate levels in peripheral blood mononuclear cells from patients receiving prolonged low-dose decitabine administration: a pilot study.Q53652472
Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine.Q34772133
Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cellsQ35851931
5-aza-2'-deoxycytidine-induced genome rearrangements are mediated by DNMT1.Q36052193
Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferaseQ36145017
In vivo quantification of active decitabine-triphosphate metabolite: a novel pharmacoanalytical endpoint for optimization of hypomethylating therapy in acute myeloid leukemiaQ36502385
Genomic impact of transient low-dose decitabine treatment on primary AML cellsQ36654140
DNA methylation as a therapeutic target in cancerQ36760984
DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cellsQ36948603
Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies.Q37372837
Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cellsQ37676784
Therapy with azanucleosides for myelodysplastic syndromesQ37765469
Epigenetic cancer therapy: rationales, targets and drugsQ37969665
The role of human equilibrative nucleoside transporter 1 on the cellular transport of the DNA methyltransferase inhibitors 5-azacytidine and CP-4200 in human leukemia cellsQ39132595
5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repairQ39162136
Capillary electrophoretic analysis of genomic DNA methylation levelsQ39698069
Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylationQ39896184
DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.Q40054309
Induction of gene expression by 5-Aza-2'-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanismsQ40498918
Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2'-deoxycytidine.Q43548377
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P433issue19
P407language of work or nameEnglishQ1860
P304page(s)e152
P577publication date2014-08-26
P1433published inNucleic Acids ResearchQ135122
P1476titleQuantitative determination of decitabine incorporation into DNA and its effect on mutation rates in human cancer cells
P478volume42

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cites work (P2860)
Q372699375-Azacytidine suppresses EC9706 cell proliferation and metastasis by upregulating the expression of SOX17 and CDH1.
Q49711997AZA-MS: a novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo
Q29147555Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer
Q93160125Intermediate-term memory in Aplysia involves neurotrophin signaling, transcription, and DNA methylation
Q36158234Lack of mutational hot spots during decitabine-mediated HIV-1 mutagenesis
Q91062619Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection
Q92659257Low doses of decitabine improve the chemotherapy efficacy against basal-like bladder cancer by targeting cancer stem cells
Q36900856Simultaneous quantitative determination of 5-aza-2'-deoxycytidine genomic incorporation and DNA demethylation by liquid chromatography tandem mass spectrometry as exposure-response measures of nucleoside analog DNA methyltransferase inhibitors
Q36972667The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells
Q64095817Tracking Decitabine Incorporation into Malignant Myeloid Cell DNA in vitro and in vivo by LC-MS/MS with Enzymatic Digestion

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