The Effect of Molecular Rapid Diagnostic Testing on Clinical Outcomes in Bloodstream Infections: A Systematic Review and Meta-analysis

scientific article published on 26 September 2016

The Effect of Molecular Rapid Diagnostic Testing on Clinical Outcomes in Bloodstream Infections: A Systematic Review and Meta-analysis is …
instance of (P31):
review articleQ7318358
meta-analysisQ815382
scholarly articleQ13442814

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P356DOI10.1093/CID/CIW649
P698PubMed publication ID27678085

P50authorEleftherios MylonakisQ56769876
P2093author name stringAisling R Caffrey
Kerry L LaPlante
Kevin W McConeghy
Tristan T Timbrook
Jacob B Morton
P2860cites workEffectiveness of Practices To Increase Timeliness of Providing Targeted Therapy for Inpatients with Bloodstream Infections: a Laboratory Medicine Best Practices Systematic Review and Meta-analysisQ26776404
Overall burden of bloodstream infection and nosocomial bloodstream infection in North America and EuropeQ27027680
Quantifying heterogeneity in a meta-analysisQ27860672
Meta-analysis in clinical trialsQ27860779
Impact of rapid organism identification via matrix-assisted laser desorption/ionization time-of-flight combined with antimicrobial stewardship team intervention in adult patients with bacteremia and candidemiaQ31125537
Hospital-acquired, laboratory-confirmed bloodstream infections: linking national surveillance data to clinical and financial hospital data to estimate increased length of stay and healthcare costsQ33551866
Real-time PCR testing for mecA reduces vancomycin usage and length of hospitalization for patients infected with methicillin-sensitive staphylococciQ33704733
Impact of antimicrobial stewardship intervention on coagulase-negative Staphylococcus blood cultures in conjunction with rapid diagnostic testingQ34058641
National multicenter study of predictors and outcomes of bacteremia upon hospital admission caused by Enterobacteriaceae producing extended-spectrum beta-lactamasesQ34309458
Integrating rapid pathogen identification and antimicrobial stewardship significantly decreases hospital costsQ34502129
Assessment of impact of peptide nucleic acid fluorescence in situ hybridization for rapid identification of coagulase-negative staphylococci in the absence of antimicrobial stewardship interventionQ35066918
Integrating rapid diagnostics and antimicrobial stewardship improves outcomes in patients with antibiotic-resistant Gram-negative bacteremiaQ35170970
Clinical impact of a real-time PCR assay for rapid identification of staphylococcal bacteremiaQ35668314
Integrating Rapid Diagnostics and Antimicrobial Stewardship in Two Community Hospitals Improved Process Measures and Antibiotic Adjustment TimeQ35887408
Randomized Trial of Rapid Multiplex Polymerase Chain Reaction-Based Blood Culture Identification and Susceptibility Testing.Q36030480
A Stewardship Approach To Optimize Antimicrobial Therapy through Use of a Rapid Microarray Assay on Blood Cultures Positive for Gram-Negative BacteriaQ36173894
Time Is of the Essence: The Impact of Delayed Antibiotic Therapy on Patient Outcomes in Hospital-Onset Enterococcal Bloodstream InfectionsQ36837889
Peptide nucleic acid fluorescent in situ hybridization for hospital-acquired enterococcal bacteremia: delivering earlier effective antimicrobial therapyQ36932977
Clinical Impact of Laboratory Implementation of Verigene BC-GN Microarray-Based Assay for Detection of Gram-Negative Bacteria in Positive Blood CulturesQ37040468
Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of AmericaQ37220711
Better tests, better care: improved diagnostics for infectious diseasesQ37287115
Stewardship approach for optimizing antimicrobial therapy through use of a rapid microarray assay on blood cultures positive for Enterococcus speciesQ37336208
Review of rapid diagnostic tests used by antimicrobial stewardship programsQ38254825
Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile rangeQ38294119
Peptide nucleic acid fluorescence in situ hybridization-based identification of Candida albicans and its impact on mortality and antifungal therapy costsQ38475730
Impact of a Rapid Blood Culture Assay for Gram-Positive Identification and Detection of Resistance Markers in a Pediatric HospitalQ39959054
Prospective intervention study with a microarray-based, multiplexed, automated molecular diagnosis instrument (Verigene system) for the rapid diagnosis of bloodstream infections, and its impact on the clinical outcomes.Q40470766
Impact of a rapid multiplex polymerase chain reaction blood culture identification technology on outcomes in patients with vancomycin-resistant Enterococcal bacteremiaQ40667972
Impact of the multiplex polymerase chain reaction in culture-positive samples on appropriate antibiotic use in patients with staphylococcal bacteremiaQ40829295
Clinical and economic impact of antimicrobial stewardship interventions with the FilmArray blood culture identification panelQ40881927
Outcomes of rapid identification for gram-positive bacteremia in combination with antibiotic stewardship at a community-based hospital system.Q41384383
Impact of a rapid microarray-based assay for identification of positive blood cultures for treatment optimization for patients with streptococcal and enterococcal bacteremiaQ41488631
Impact of same-day antibiotic susceptibility testing on time to appropriate antibiotic treatment of patients with bacteraemia: a randomised controlled trial.Q41589486
Clinical impact of a PCR assay for rapid identification of Klebsiella pneumoniae in blood culturesQ41913418
Risk of bias versus quality assessment of randomised controlled trials: cross sectional studyQ42081186
An antimicrobial stewardship program's impact with rapid polymerase chain reaction methicillin-resistant Staphylococcus aureus/S. aureus blood culture test in patients with S. aureus bacteremiaQ42873721
Impact of a rapid peptide nucleic acid fluorescence in situ hybridization assay on treatment of Candida infectionsQ45220026
Direct mecA polymerase chain reaction testing of blood culture bottles growing Gram-positive cocci and the clinical potential in optimizing antibiotic therapy for staphylococcal bacteremiaQ46451322
Clinical impact of a real-time PCR assay for rapid identification of Staphylococcus aureus and determination of methicillin resistance from positive blood cultures.Q54432834
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmeta-analysisQ815382
systematic reviewQ1504425
P304page(s)15-23
P577publication date2016-09-26
P1433published inClinical Infectious DiseasesQ5133764
P1476titleThe Effect of Molecular Rapid Diagnostic Testing on Clinical Outcomes in Bloodstream Infections: A Systematic Review and Meta-analysis
P478volume64

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cites work (P2860)
Q91902727A Systematic Review and Meta-analysis of Antibiotic Treatment Duration for Bacteremia Due to Enterobacteriaceae
Q89080678A rare fungus on the rise: Candida auris
Q90405143Accelerating Initiation of Adequate Antimicrobial Therapy Using Real-Time Decision Support and Microarray Testing
Q52372579An Antibiotic Stewardship Program Blueprint for Optimizing Verigene BC-GN within an Institution: a Tale of Two Cities.
Q55262380An Automated Sample Preparation Instrument to Accelerate Positive Blood Cultures Microbial Identification by MALDI-TOF Mass Spectrometry (Vitek®MS).
Q91699767Antibiotic stewardship in the intensive care unit: Challenges and opportunities
Q64128215Antimicrobial susceptibility testing of pathogens isolated from blood culture: a performance comparison of Accelerate Pheno™ and VITEK® 2 systems with the broth microdilution method
Q89669079Bloodstream infections in critically ill patients: an expert statement
Q90087449Challenges and research priorities to progress the impact of antimicrobial stewardship
Q93037645Clinical Performance of the Novel GenMark Dx ePlex Blood Culture ID Gram-Positive Panel
Q92883659Clinical Utility of Advanced Microbiology Testing Tools
Q91969987Collaborative Antimicrobial Stewardship: Working with Microbiology
Q64949952Comparing Patient Risk Factor-, Sequence Type-, and Resistance Locus Identification-Based Approaches for Predicting Antibiotic Resistance in Escherichia coli Bloodstream Infections.
Q57461242Comparison of Pharmacist-Directed Management of Multiplex PCR Blood Culture Results with Conventional Microbiology Methods on Effective and Optimal Therapy within a Community Hospital
Q64953308Comparison of the Fully Automated FilmArray BCID Assay to a 4-Hour Culture Test Coupled to Mass Spectrometry for Day 0 Identification of Microorganisms in Positive Blood Cultures.
Q91675647Development of a Multiplex PCR Platform for the Rapid Detection of Bacteria, Antibiotic Resistance, and Candida in Human Blood Samples
Q91674620Diagnosing and Managing Sepsis by Probing the Host Response to Infection: Advances, Opportunities, and Challenges
Q53701537Diagnostic Stewardship: Opportunity for a Laboratory-Infectious Diseases Partnership.
Q49609584Disease-based antimicrobial stewardship: a review of active and passive approaches to patient management.
Q95264399ERS International Congress, Madrid, 2019: highlights from the Respiratory Infections Assembly
Q36287903Effect of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) Alone versus MALDI-TOF MS Combined with Real-Time Antimicrobial Stewardship Interventions on Time to Optimal Antimicrobial Therapy in Patients with
Q53690859Evaluation of a real-time PCR assay for detection and quantification of bacterial DNA directly in blood of preterm neonates with suspected late-onset sepsis.
Q49545992Evaluation of the Accelerate Pheno™ System: Results from Two Academic Medical Centers.
Q58440392Evaluation of the Accelerate Pheno™ system for rapid identification and antimicrobial susceptibility testing of Gram-negative bacteria in bloodstream infections
Q58577357Impact of a Multiplex PCR Assay for Bloodstream Infections With and Without Antimicrobial Stewardship Intervention at a Cancer Hospital
Q90016262Impact of an Antimicrobial Stewardship Bundle for Uncomplicated Gram-Negative Bacteremia
Q40202447Impact of antimicrobial stewardship and rapid microarray testing on patients with Gram-negative bacteremia
Q91994650Impact of infectious diseases consultation on the outcome of patients with bacteraemia
Q96638650Impact of rapid diagnostics with antimicrobial stewardship support for children with positive blood cultures: A quasi-experimental study with time trend analysis
Q40109286Impact of rapid identification of positive blood cultures using the Verigene system on antibiotic prescriptions: A prospective study of community-onset bacteremia in a tertiary hospital in Japan.
Q89408653Implementation and optimization of molecular rapid diagnostic tests for bloodstream infections
Q100572679Implementation of infectious diseases rapid molecular diagnostic tests and antimicrobial stewardship program involvement in acute-care hospitals
Q99356953Inappropriate empirical antibiotic therapy for bloodstream infections based on discordant in-vitro susceptibilities: a retrospective cohort analysis of prevalence, predictors, and mortality risk in US hospitals
Q40083539Incidence, prevalence, and management of MRSA bacteremia across patient populations-a review of recent developments in MRSA management and treatment
Q60949850Laboratory Automation in Clinical Microbiology
Q58781572Management and outcome of bloodstream infections: a prospective survey in 121 French hospitals (SPA-BACT survey)
Q38737360Molecular antibiogram in diagnostic clinical microbiology: advantages and challenges
Q48300852Multicenter Evaluation of the Accelerate PhenoTest™ BC Kit for Rapid Identification and Phenotypic Antimicrobial Susceptibility Testing Using Morphokinetic Cellular Analysis.
Q40218550Pharmacists' Familiarity with and Institutional Utilization of Rapid Diagnostic Technologies for Antimicrobial Stewardship.
Q60937003Predictors of Time to Effective and Optimal Antimicrobial Therapy in Patients With Positive Blood Cultures Identified via Molecular Rapid Diagnostic Testing
Q47398868Recent advances in the microbiological diagnosis of bloodstream infections.
Q50123871Research Agenda for Antimicrobial Stewardship in the Veterans Health Administration.
Q47647007Risk Factors and Outcomes for Ineffective Empiric Treatment of Sepsis Caused by Gram-Negative Pathogens: Stratification by Onset of Infection
Q40067736Significant Publications on Infectious Diseases Pharmacotherapy in 2016.
Q89414736Surviving sepsis campaign: research priorities for sepsis and septic shock
Q64261054Susceptibility Provision Enhances Effective De-escalation (SPEED): utilizing rapid phenotypic susceptibility testing in Gram-negative bloodstream infections and its potential clinical impact
Q41992934Sustained impact of a rapid microarray-based assay with antimicrobial stewardship interventions on optimizing therapy in patients with Gram-positive bacteraemia
Q47710544Syndromic Panel-Based Testing in Clinical Microbiology.
Q88923903The Cost-Effectiveness of Rapid Diagnostic Testing for the Diagnosis of Bloodstream Infections with or without Antimicrobial Stewardship
Q90594919The Hypothetical Impact of Accelerate Pheno on Time to Effective Therapy and Time to Definitive Therapy for Bloodstream Infections Due to Drug-Resistant Gram-Negative Bacilli
Q50048893The Role of an Antimicrobial Stewardship Team in the Use of Rapid Diagnostic Testing in Acute Care: An Official Position Statement of the Society of Infectious Diseases Pharmacists.
Q90306449The impact of a rapid molecular identification test on positive blood cultures from critically ill with bacteremia: A pre-post intervention study
Q30238578The intensive care medicine research agenda on multidrug-resistant bacteria, antibiotics, and stewardship.
Q50048345Understanding inpatient antimicrobial stewardship metrics.
Q90167656Using Genetic Distance from Archived Samples for the Prediction of Antibiotic Resistance in Escherichia coli
Q90653096Validation of an Antimicrobial Stewardship-Driven Verigene Blood-Culture Gram-Negative Treatment Algorithm to Improve Appropriateness of Antibiotics
Q91607474Variability in antifungal stewardship strategies among Society for Healthcare Epidemiology of America (SHEA) Research Network facilities
Q91765584Will biomarkers be the answer for antibiotic stewardship?

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