Excision of uracil from transcribed DNA negatively affects gene expression

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Excision of uracil from transcribed DNA negatively affects gene expression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M113.521807
P932PMC publication ID4139217
P698PubMed publication ID24951587
P5875ResearchGate publication ID263288668

P2093author name stringBernd Epe
Andriy Khobta
Bork Lühnsdorf
P2860cites workInstability and decay of the primary structure of DNAQ22122361
APOBEC3 proteins mediate the clearance of foreign DNA from human cellsQ24294583
hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backupQ24303661
Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG geneQ24317201
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sitesQ28145111
Base excision repairQ28288115
Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylaseQ28345101
Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stabilityQ28508931
DNA damage response and transcriptionQ33915024
Green fluorescent protein is a quantitative reporter of gene expression in individual eukaryotic cellsQ33984267
Uracil in DNA--occurrence, consequences and repairQ34165028
Single-stranded breaks in DNA but not oxidative DNA base damages block transcriptional elongation by RNA polymerase II in HeLa cell nuclear extracts.Q34300281
B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracilQ34427857
The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNAQ34811750
Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.Q34947427
Uracil in duplex DNA is a substrate for the nucleotide incision repair pathway in human cellsQ34983433
Interference of mismatch and base excision repair during the processing of adjacent U/G mispairs may play a key role in somatic hypermutationQ37138006
Modulation of base excision repair of 8-oxoguanine by the nucleotide sequenceQ37224704
Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cellsQ37592323
Dealing with DNA damage: relationships between checkpoint and repair pathwaysQ37652807
Interactions between DNA damage, repair, and transcription.Q37930062
Transcription-replication encounters, consequences and genomic instabilityQ38095707
Causes of genome instabilityQ38126068
Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1.Q38293786
8-Oxo-7,8-dihydroguanine in DNA does not constitute a barrier to transcription, but is converted into transcription-blocking damage by OGG1.Q39569784
The rate of base excision repair of uracil is controlled by the initiating glycosylaseQ39948030
Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylaseQ40406818
The specific binding of nuclear protein(s) to the cAMP responsive element (CRE) sequence (TGACGTCA) is reduced by the misincorporation of U and increased by the deamination of CQ40524511
A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energyQ41203605
Gene silencing induced by oxidative DNA base damage: association with local decrease of histone H4 acetylation in the promoter regionQ42121552
Competition between the RNA transcript and the nontemplate DNA strand during R-loop formation in vitro: a nick can serve as a strong R-loop initiation siteQ42947445
Effects of endogenous DNA base lesions on transcription elongation by mammalian RNA polymerase II. Implications for transcription-coupled DNA repair and transcriptional mutagenesis.Q44238573
Transcription arrest at an abasic site in the transcribed strand of template DNA.Q46704150
Kinetics of the action of thymine DNA glycosylaseQ47761945
Generation of reporter plasmids containing defined base modifications in the DNA strand of choice.Q50501056
Properties of a Recombinant Human Uracil-DNA Glycosylase from the UNG Gene and Evidence that UNG Encodes the Major Uracil-DNA GlycosylaseQ57942555
P433issue32
P407language of work or nameEnglishQ1860
P304page(s)22008-22018
P577publication date2014-06-20
P1433published inJournal of Biological ChemistryQ867727
P1476titleExcision of uracil from transcribed DNA negatively affects gene expression
P478volume289

Reverse relations

cites work (P2860)
Q91558544Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression
Q92391312Deoxyuracil in DNA and disease: Genomic signal or managed situation?
Q38727052Digital gene expression profiling analysis of DNA repair pathways in colon cancer stem population of HT29 cells
Q37270321Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells.
Q47700209Functional impacts of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoter.
Q48552385Metabolic profiling of umbilical cord blood in macrosomia
Q37228837Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine

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