The "ins and outs" of complement-driven immune responses.

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The "ins and outs" of complement-driven immune responses. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/IMR.12472
P932PMC publication ID5102160
P698PubMed publication ID27782335

P50authorGaelle Le FriecQ60487788
Claudia KemperQ73090566
P2093author name stringSimon Freeley
P2860cites workAntigen presentation and T cell stimulation by dendritic cellsQ22255632
Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissueQ24292702
Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotypeQ24293121
The CD46-Jagged1 interaction is critical for human TH1 immunityQ24301407
CD19: lowering the threshold for antigen receptor stimulation of B lymphocytesQ24338598
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 miceQ24604235
Posttranscriptional control of T cell effector function by aerobic glycolysisQ24606942
Four viruses, two bacteria, and one receptor: membrane cofactor protein (CD46) as pathogens' magnetQ24623803
Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytesQ24680369
Structure of the poly-C9 component of the complement membrane attack complexQ28115911
Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthmaQ28142956
Signal transduction through decay-accelerating factor. Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine kinases p56lck and p59fyn 1Q28188748
Defensins: antimicrobial peptides of innate immunityQ28204453
The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)Q28214372
Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complementQ28237531
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory responseQ28242527
Complement deficiency states and infection: epidemiology, pathogenesis and consequences of neisserial and other infections in an immune deficiencyQ28268386
T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.Q37241002
A novel "complement-metabolism-inflammasome axis" as a key regulator of immune cell effector functionQ37260702
Interaction between the coagulation and complement systemQ37331658
Functions of C5a receptorsQ37369597
Intracellular complement activation sustains T cell homeostasis and mediates effector differentiationQ37397572
Arachidonate metabolism by human polymorphonuclear leukocytes stimulated by N-formyl-Met-Leu-Phe or complement component C5a is independent of phospholipase activationQ37509006
Structure and function of the leukocyte adhesion molecules CD11/CD18.Q37580454
The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis.Q37627550
Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2Q37652278
Identification of an additional class of C3-binding membrane proteins of human peripheral blood leukocytes and cell linesQ37677073
Specialized roles for cysteine cathepsins in health and disease.Q37797839
The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domainQ28285921
The internal thioester and the covalent binding properties of the complement proteins C3 and C4Q28304143
Complement and its receptors: new insights into human diseaseQ28307316
The receptor NLRP3 is a transcriptional regulator of TH2 differentiationQ28512758
Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infectionQ28817811
Innate or adaptive immunity? The example of natural killer cellsQ29615106
Aerobic glycolysis: meeting the metabolic requirements of cell proliferationQ29615178
Complement: a key system for immune surveillance and homeostasisQ29615484
Activation and regulation of the inflammasomesQ29615664
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complexQ29617214
Physiological roles of mitochondrial reactive oxygen speciesQ29620297
Generation of anaphylatoxins by human beta-tryptase from C3, C4, and C5Q30439751
Complement regulators and inhibitory proteinsQ33386110
Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell ResponsesQ33423703
Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cellsQ33570304
Variable morbidity in alagille syndrome: a review of 43 casesQ33747368
The dynamic processing of CD46 intracellular domains provides a molecular rheostat for T cell activationQ33809500
CR3: a general purpose adhesion-recognition receptor essential for innate immunityQ33887451
Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells.Q34000160
Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.Q34086998
A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarizationQ34102432
Cellular response to oxidative stress: signaling for suicide and survivalQ34138566
Role of Complement in Induction of the Allergic ResponseQ34212341
Intracellular sensing of complement C3 activates cell autonomous immunity.Q34231523
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activationQ34242691
Complement regulatory protein CD46 protects against choroidal neovascularization in miceQ34299745
IL-7 is essential for homeostatic control of T cell metabolism in vivoQ34307992
Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection.Q34550742
C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cellsQ34579613
Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cellsQ34760201
Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathyQ34836376
C5a-induced gene expression in human umbilical vein endothelial cellsQ35094695
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cellsQ35102340
Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosisQ35127765
NLRP3 inflammasomes link inflammation and metabolic diseaseQ35151726
Mice Deficient in Complement Receptors 1 and 2 Lack a Tissue Injury-Inducing Subset of the Natural Antibody RepertoireQ57331400
Local synthesis of complement component C3 regulates acute renal transplant rejectionQ57369617
Generation of C5a in the absence of C3: a new complement activation pathwayQ58523865
Complement protein C1q induces maturation of human dendritic cellsQ60861601
Complement plays a central role in Candida albicans-induced cytokine production by human PBMCsQ61441031
Brief Report: Complement C5a Promotes Human Embryonic Stem Cell Pluripotency in the Absence of FGF2Q63916944
Purification and partial characterization of human and porcine C3a anaphylatoxinQ67506949
Suppression of the Immune Response by a Soluble Complement Receptor of B LymphocytesQ67701907
Chemotaxis by mouse macrophage cell linesQ70765924
Increased expression of C3b receptors on polymorphonuclear leukocytes induced by chemotactic factors and by purification proceduresQ71726410
Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokinesQ71746654
Activation of human neutrophils by C3a and C5A. Comparison of the effects on shape changes, chemotaxis, secretion, and respiratory burstQ72020363
C3a activates reactive oxygen radical species production and intracellular calcium transients in human eosinophilsQ72285861
C3a activates the respiratory burst in human polymorphonuclear neutrophilic leukocytes via pertussis toxin-sensitive G-proteinsQ72454839
Characterization of accessory molecules in murine lung dendritic cell function: roles for CD80, CD86, CD54, and CD40LQ73155746
Crry/p65, a membrane complement regulatory protein, has costimulatory properties on mouse T cellsQ73709052
Complement c3a and c5a induce different signal transduction cascades in endothelial cellsQ74583305
A critical role for complement in maintenance of self-toleranceQ77658426
Alterations in C3 activation and binding caused by phosphorylation by a casein kinase released from activated human plateletsQ77841687
A role for mammalian target of rapamycin in regulating T cell activation versus anergyQ79717975
Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interactionQ80140686
Complement--tapping into new sites and effector systemsQ85959086
The role of complement in the diagnosis and management of allergic rhinitis and allergic asthmaQ37822299
Sensing disease and danger: a survey of vertebrate PRRs and their originsQ37829490
Granzyme B: a new crossroad of complement and apoptosisQ37938946
IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasisQ38007051
Biochemical regulation of the inflammasomeQ38017287
Regulation of humoral immunity by complementQ38037801
Metabolism of inflammation limited by AMPK and pseudo-starvationQ38074586
The role of complement in CD4⁺ T cell homeostasis and effector functionsQ38110968
Primary complement C5 deficiencies - molecular characterization and clinical review of two familiesQ38112539
Training innate immunity: the changing concept of immunological memory in innate host defenceQ38122699
Mechanisms of NOD-like receptor-associated inflammasome activationQ38140207
CD46: the 'multitasker' of complement proteins.Q38152144
NLRP3 at the interface of metabolism and inflammation.Q38423371
Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the C5a receptor.Q39032467
Cytokines in inflammatory bowel diseaseQ39206254
Release of histamine from rat mast cells by the complement peptides C3a and C5a.Q39327002
The gut microbiota modulates host energy and lipid metabolism in miceQ39993460
Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble formQ40526230
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory developmentQ40760682
Functional modulation of human macrophages through CD46 (measles virus receptor): production of IL-12 p40 and nitric oxide in association with recruitment of protein-tyrosine phosphatase SHP-1 to CD46.Q40846624
Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylationQ40875377
Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylationQ40902413
Complement drives Th17 cell differentiation and triggers autoimmune arthritis.Q40952250
C3a and C5a stimulate chemotaxis of human mast cellsQ41115852
Extrahepatic complement biosynthesis: where, when and why?Q41331539
Inherited complement C3 deficiency: a defect in C3 secretionQ41456840
Increased B cell deletion and significantly reduced auto-antibody titre due to premature expression of human complement receptor 2 (CR2, CD21).Q41780931
Role of complement in induction of antibody production in vivo. Effect of cobra factor and other C3-reactive agents on thymus-dependent and thymus-independent antibody responsesQ41921458
Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation.Q41957299
Functional analysis of C5a effector responses in vitro and in vivoQ42241097
Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthmaQ42423633
Autophagy induction by the pathogen receptor CD46.Q42461485
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitmentQ42593305
Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation.Q43630649
Histamine-induced inhibition of normal human basophil chemotaxis to C5aQ43966141
Renal expression of the C3a receptor and functional responses of primary human proximal tubular epithelial cellsQ45050747
Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infectionQ45733086
Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro.Q46010319
ATP-P2X4 signaling mediates NLRP3 inflammasome activation: a novel pathway of diabetic nephropathyQ46577083
C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation.Q47954758
Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.Q50959906
Human C3 deficiency associated with impairments in dendritic cell differentiation, memory B cells, and regulatory T cells.Q51961907
Factor VII-activating protease is activated in multiple trauma patients and generates anaphylatoxin C5a.Q53669943
Proinflammatory activation pattern of human umbilical vein endothelial cells induced by IL-1β, TNF-α, and LPS.Q54615593
Dendritic cell function in allostimulation is modulated by C5aR signaling.Q54712683
Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodiesQ57089602
Organ-specific contribution to circulating C7 levels by the bone marrow and liver in humansQ57089607
Extrahepatic secreted complement C3 contributes to circulating C3 levels in humansQ57089621
Tissue-specific expression of CD46 isoformsQ57272519
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammationQ35242438
The evolution of mouse and human complement C3-binding proteins: divergence of form but conservation of functionQ35326510
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.Q35350543
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.Q35404457
Membrane cofactor proteinQ35483434
Functional modulation of human monocytes derived DCs by anaphylatoxins C3a and C5a.Q35603188
Regulation of JAK-STAT signalling in the immune systemQ35605437
Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivoQ35642856
The complement system in B cell regulationQ35781836
Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18)Q35868877
C5aR expression in a novel GFP reporter gene knockin mouse: implications for the mechanism of action of C5aR signaling in T cell immunityQ35884221
The complement system in regulation of adaptive immunityQ35904390
A novel role for CD46 in wound repairQ35928410
T-cell stimulation and regulation: with complements from CD46.Q36232659
The derivation of two distinct anaphylatoxin activities from the third and fifth components of human complementQ36268987
Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for polymorphonuclear leukocytesQ36269256
Receptors for complement of leukocytesQ36269375
Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell deathQ36365164
Decay-accelerating factor modulates induction of T cell immunityQ36403001
The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivoQ36403243
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survivalQ36445850
Complement regulatory protein Crry deficiency contributes to the antigen specific recall response in experimental autoimmune myasthenia gravis.Q36471905
The role of third complement component (C3) in homing of hematopoietic stem/progenitor cells into bone marrow.Q36558411
Self, non-self, and danger: a complementary viewQ36558427
Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cellsQ36603536
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.Q36639793
T-cell regulation: with complements from innate immunityQ36684909
Metabolic regulation of T lymphocytesQ36711431
Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapyQ36723728
Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosisQ36843709
The role of the complement anaphylatoxins in the recruitment of eosinophilsQ37015015
CFH Y402H polymorphism and the complement activation product C5a: effects on NF-κB activation and inflammasome gene regulationQ37088454
Decay accelerating factor can control T cell differentiation into IFN-gamma-producing effector cells via regulating local C5a-induced IL-12 productionQ37106187
Donor deficiency of decay-accelerating factor accelerates murine T cell-mediated cardiac allograft rejectionQ37106399
P433issue1
P304page(s)16-32
P577publication date2016-11-01
P1433published inImmunological ReviewsQ15724582
P1476titleThe "ins and outs" of complement-driven immune responses
P478volume274

Reverse relations

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