Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

scientific article

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI76012
P932PMC publication ID4382238
P698PubMed publication ID25437876

P50authorJason W. LocasaleQ41047918
Andrew N MacintyreQ55283734
Christopher B NewgardQ87867408
P2093author name stringLaurence A Turka
Makoto Inoue
Olga Ilkayeva
Xiaojing Liu
Mari L Shinohara
Paul A Smith
Laura P Hale
Jeffrey C Rathmell
Bhavana Priyadharshini
Kris C Wood
Peter S Winter
Nancie J MacIver
Rigel J Kishton
Amanda G Nichols
Valerie A Gerriets
Martin A Schneider
Lea Haeberli
Catherine Huck
Marta E Slawinska
P2860cites workPyruvate dehydrogenase kinase as a novel therapeutic target in oncologyQ21129303
Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenaseQ24291531
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolismQ24300524
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1Q24336199
Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicolQ24336876
Understanding the Warburg effect: the metabolic requirements of cell proliferationQ24604760
Posttranscriptional control of T cell effector function by aerobic glycolysisQ24606942
Acylcarnitines: reflecting or inflicting insulin resistance?Q27004603
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsQ27860620
Metabolic modulation of glioblastoma with dichloroacetateQ28282255
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainQ29614225
Differentiation of effector CD4 T cell populations (*)Q29614838
NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitisQ30519470
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activationQ34242691
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6Q34521302
The CD28 signaling pathway regulates glucose metabolismQ34525357
Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseasesQ34615216
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cellsQ35102340
Attenuation of experimental colitis in glutathione peroxidase 1 and catalase double knockout mice through enhancing regulatory T cell functionQ35151625
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.Q35404457
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiationQ35546707
The role of low-level lactate production in airway inflammation in asthmaQ35786791
Fuel feeds function: energy metabolism and the T-cell responseQ36292868
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.Q36639793
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunityQ36839721
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiationQ36903810
Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.Q36995837
Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survivalQ37199519
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.Q37200886
Dichloroacetate induces protective autophagy in LoVo cells: involvement of cathepsin D/thioredoxin-like protein 1 and Akt-mTOR-mediated signalingQ37357063
Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 miceQ37454035
Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancerQ37612417
Development and quantitative evaluation of a high-resolution metabolomics technologyQ37696918
The IL-17 differentiation pathway and its role in transplant outcomeQ37973866
Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cellsQ38714538
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.Q39150145
Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress.Q39285117
Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC.Q39695465
Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivoQ39835139
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory developmentQ40760682
Dichloroacetate at therapeutic concentration alters glucose metabolism and induces regulatory T-cell differentiation in alloreactive human lymphocytesQ43532816
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistanceQ44760628
Piroxicam treatment of IL-10-deficient mice enhances colonic epithelial apoptosis and mucosal exposure to intestinal bacteriaQ46819055
Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system.Q53846430
Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress-induced cell deathQ82807884
Ablation of peroxiredoxin II attenuates experimental colitis by increasing FoxO1-induced Foxp3+ regulatory T cellsQ85949110
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)194-207
P577publication date2014-12-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleMetabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
P478volume125

Reverse relations

cites work (P2860)
Q387015116-mercaptopurine promotes energetic failure in proliferating T cells
Q64078967A Metabolism Toolbox for CAR T Therapy
Q38891307A guide to immunometabolism for immunologists.
Q36800650AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.
Q40540223Alkaline Cytosolic pH and High Sodium Hydrogen Exchanger 1 (NHE1) Activity in Th9 Cells.
Q60950933Anergy into T regulatory cells: an integration of metabolic cues and epigenetic changes at the Foxp3 conserved non-coding sequence 2
Q49546319Antitumor T cell reconditioning: improving metabolic fitness for optimal cancer immunotherapy.
Q89947934Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells
Q38635598Assessment of metabolic and mitochondrial dynamics in CD4+ and CD8+ T cells in virologically suppressed HIV-positive individuals on combination antiretroviral therapy
Q47126247Attenuation of CD4+CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug
Q36586185Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis
Q91497249Bile acid metabolites control TH17 and Treg cell differentiation
Q39313207Biochemical Underpinnings of Immune Cell Metabolic Phenotypes
Q38622052CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs.
Q50054341CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response.
Q36789958Cell surface Glut1 levels distinguish human CD4 and CD8 T lymphocyte subsets with distinct effector functions
Q33423703Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses
Q37248499Complement-Mediated Regulation of Metabolism and Basic Cellular Processes
Q26781587Control of macrophage metabolism and activation by mTOR and Akt signaling
Q99711564Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1α-Dependent Glycolysis
Q40409859Cutting Edge: Murine Mast Cells Rapidly Modulate Metabolic Pathways Essential for Distinct Effector Functions
Q57464697Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets
Q38737991Cytochrome c Oxidase Activity Is a Metabolic Checkpoint that Regulates Cell Fate Decisions During T Cell Activation and Differentiation
Q58390470DNA methylation regulates the neonatal CD4 T-cell response to pneumonia in mice
Q46475452Dichloroacetate induces regulatory T-cell differentiation and suppresses Th17-cell differentiation by pyruvate dehydrogenase kinase-independent mechanism
Q61800041Differential Regulation of Human Treg and Th17 Cells by Fatty Acid Synthesis and Glycolysis
Q62748170Differential T-cell receptor signals for T helper cell programming
Q53422663Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity.
Q58589986Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism
Q60303325Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming
Q39272251Dysfunctional T cell metabolism in the tumor microenvironment
Q92072023ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation
Q50098031Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions.
Q40745622Emerging concepts of T cell metabolism as a target of immunotherapy.
Q92614033Enhanced oxidative phosphorylation in NKT cells is essential for their survival and function
Q94565400Entry of glucose- and glutamine-derived carbons into the citric acid cycle supports early steps of HIV-1 infection in CD4 T cells
Q99416008Exercise immunology: Future directions
Q49257611Exploiting immune cell metabolic machinery for functional HIV cure and the prevention of inflammaging.
Q47128955Exploring Non-Metabolic Functions of Glycolytic Enzymes in Immunity
Q57160050Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth
Q39223057Fine tuning of immunometabolism for the treatment of rheumatic diseases
Q47914208Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments.
Q46215374Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression
Q37624347Foxp3 drives oxidative phosphorylation and protection from lipotoxicity.
Q33834498From Krebs to clinic: glutamine metabolism to cancer therapy.
Q40232460Fuelling the mechanisms of asthma: Increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target.
Q92432963Functional reprogramming of regulatory T cells in the absence of Foxp3
Q26747110Glucose Metabolism in T Cells and Monocytes: New Perspectives in HIV Pathogenesis
Q36387092Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.
Q40484358Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Q90658517Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function
Q58753648Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation
Q36904140Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants
Q64083937HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma
Q41678886HIF1α and metabolic reprogramming in inflammation.
Q38732972Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease
Q92342000Helper T cell differentiation
Q47551069Hexokinase II may be dispensable for CD4 T cell responses against a virus infection.
Q42198502Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions
Q38854617High density lipoproteins selectively promote the survival of human regulatory T cells
Q89983091Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism
Q92482424Homeostasis and transitional activation of regulatory T cells require c-Myc
Q36952049Homocysteine activates T cells by enhancing endoplasmic reticulum-mitochondria coupling and increasing mitochondrial respiration
Q91339440How to reprogram microglia toward beneficial functions
Q40097257Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?
Q89882621Hyperactive PI3Kδ predisposes naive T cells to activation via aerobic glycolysis programs
Q26781659Hyperpolarized (13)C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused Organs
Q49725890Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment.
Q37258774IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
Q91808408ILC3s integrate glycolysis and mitochondrial production of reactive oxygen species to fulfill activation demands
Q90050590Immunometabolic Checkpoints of Treg Dynamics: Adaptation to Microenvironmental Opportunities and Challenges
Q37712496Immunometabolic Regulation of Interleukin-17-Producing T Helper Cells: Uncoupling New Targets for Autoimmunity.
Q50054528Immunometabolism and PI(3)K Signaling As a Link between IL-2, Foxp3 Expression, and Suppressor Function in Regulatory T Cells.
Q38937346Immunometabolism and autoimmunity
Q64054632Immunometabolism of Phagocytes and Relationships to Cardiac Repair
Q28074509Immunometabolism of regulatory T cells
Q50085942Immunometabolism, pregnancy, and nutrition.
Q92298634Immunometabolism: A target for the comprehension of immune response toward transplantation
Q38624726Immunometabolism: Cellular Metabolism Turns Immune Regulator
Q48046289Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis.
Q38686210Integrated regulation of the cellular metabolism and function of immune cells in adipose tissue
Q98665193Lactate modulation of immune responses in inflammatory versus tumour microenvironments
Q39738326Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity
Q30252405Lineage-Specific Metabolic Properties and Vulnerabilities of T Cells in the Demyelinating Central Nervous System.
Q43097037MINK1: The missing link between ROS and its inhibition of Th17 cells
Q40097679Manipulating Glucose Metabolism during Different Stages of Viral Pathogenesis Can Have either Detrimental or Beneficial Effects
Q90043581Melanoma Metabolism: Cell Survival and Resistance to Therapy
Q89627075Memory T cells in transplantation: old challenges define new directions
Q64080801Merger of dynamic two-photon and phosphorescence lifetime microscopy reveals dependence of lymphocyte motility on oxygen in solid and hematological tumors
Q96348555Met-Flow, a strategy for single-cell metabolic analysis highlights dynamic changes in immune subpopulations
Q54985437Metabolic Adaptations of CD4+ T Cells in Inflammatory Disease.
Q61448742Metabolic Checkpoints in Differentiation of Helper T Cells in Tissue Inflammation
Q41437712Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Q92072375Metabolic Pathways Involved in Regulatory T Cell Functionality
Q39418546Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy
Q55285363Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity.
Q39313214Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity
Q90272929Metabolic checkpoints in neurodegenerative T helper 17 (TH17) and neuroregenerative regulatory T (Treg) cells as new therapeutic targets for multiple sclerosis
Q59256385Metabolic control of T cell immune response through glycans in inflammatory bowel disease
Q38786619Metabolic control of arthritis: Switch pathways to treat
Q92578624Metabolic coordination of T cell quiescence and activation
Q40049632Metabolic orchestration of T lineage differentiation and function
Q51617878Metabolic plasticity of human T cells: Preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2-deoxy-glucose affects effector functions.
Q92569677Metabolic regulation of TH17 cells
Q39194474Metabolic regulation of inflammation
Q57181197Metabolic regulation of innate and adaptive lymphocyte effector responses
Q39244812Metabolic reprograming of anti-tumor immunity
Q39617623Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation
Q59418269Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells
Q47118555Metabolism Controls the Balance of Th17/T-Regulatory Cells.
Q40065267Metabolism in Immune Cell Differentiation and Function.
Q97424076Metabolism of immune cells in cancer
Q56418745Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase
Q26992186Mitochondria in the regulation of innate and adaptive immunity
Q55100716Mitochondria: An Organelle of Bacterial Origin Controlling Inflammation.
Q92296866Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function
Q36562453Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.
Q90044590Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development
Q37262107Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses.
Q90971059Mitochondrial complex III is essential for suppressive function of regulatory T cells
Q39410087Mitochondrial control of immunity: beyond ATP.
Q90608748Mitochondrial fidelity and metabolic agility control immune cell fate and function
Q45829514Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia
Q49990145Navigating T-Cell Immunometabolism in Transplantation.
Q33780993Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease
Q92610514Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized 13C magnetic resonance
Q90721995Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity
Q37689449Nutrient and Metabolic Sensing in T Cell Responses
Q39068014Nutritional effects on T-cell immunometabolism
Q50193692O-GlcNAc: a novel regulator of immunometabolism.
Q34538613Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Q36515067PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis
Q39434888Pathogenic Role of IL-17-Producing Immune Cells in Obesity, and Related Inflammatory Diseases
Q64106873Peptidoglycan Muropeptides: Release, Perception, and Functions as Signaling Molecules
Q99412452Peritoneal dialysate-range hypertonic glucose promotes T cell IL-17 production that induces mesothelial inflammation
Q59805349Progresses and Perspectives of Anti-PD-1/PD-L1 Antibody Therapy in Head and Neck Cancers
Q38806412Protein Kinase CK2 Controls the Fate between Th17 Cell and Regulatory T Cell Differentiation.
Q58792292Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival
Q92884393Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation
Q47620230Recipe for IBD: can we use food to control inflammatory bowel disease?
Q50026803Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42.
Q49861299Regulatory T Cell Metabolism in the Hepatic Microenvironment.
Q92489012Regulatory T cell adaptation in the intestine and skin
Q100694982Regulatory t cell metabolism at the intersection between autoimmune diseases and cancer
Q37357112Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis
Q38957379Role of Metabolism in the Immunobiology of Regulatory T Cells
Q55315202Rotenone Treatment Reveals a Role for Electron Transport Complex I in the Subcellular Localization of Key Transcriptional Regulators During T Helper Cell Differentiation.
Q91755202Short-chain fatty acids: Bacterial messengers modulating the immunometabolism of T cells
Q39418532Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors
Q93016064Solute carrier transporters: the metabolic gatekeepers of immune cells
Q40246921Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1.
Q38566464Synchronizing transcriptional control of T cell metabolism and function
Q96303611T Cell Metabolism: A New Perspective on Th17/Treg Cell Imbalance in Systemic Lupus Erythematosus
Q91645219T cell Metabolism in Lupus
Q35371293T cell metabolic fitness in antitumor immunity
Q38567424T cell metabolic reprogramming and plasticity
Q26799575T cell metabolism drives immunity
Q92712487T cell metabolism: new insights in systemic lupus erythematosus pathogenesis and therapy
Q38915095T-cell metabolism governing activation, proliferation and differentiation; a modular view
Q92001038TCR Dependent Metabolic Programming Regulates Autocrine IL-4 Production Resulting in Self-Tuning of the CD8+ T Cell Activation Setpoint
Q57815155TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy
Q91536702Targeted Metabolic Reprogramming to Improve the Efficacy of Oncolytic Virus Therapy
Q46792366Targeting HIF-1α/PDK1 Axis by Dichloroacetate (DCA) Suppresses Bleomycin-induced Pulmonary Fibrosis
Q39099620Targeting Metabolism as a Novel Therapeutic Approach to Autoimmunity, Inflammation, and Transplantation
Q90681179Targeting T Cell Metabolism in Inflammatory Skin Disease
Q39315870Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease
Q92297313Targeting metabolism to regulate immune responses in autoimmunity and cancer
Q41859862Th17 Polarization under Hypoxia Results in Increased IL-10 Production in a Pathogen-Independent Manner
Q47585318Th17/Treg immunoregulation and implications in treatment of sulfur mustard gas-induced lung diseases
Q38991066The "ins and outs" of complement-driven immune responses.
Q37729333The Glyoxalase System and Methylglyoxal-Derived Carbonyl Stress in Sepsis: Glycotoxic Aspects of Sepsis Pathophysiology
Q90176770The Impact of Dietary Components on Regulatory T Cells and Disease
Q38919518The PI3K pathway in B cell metabolism
Q36596905The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements
Q49630753The Role of Lipid Metabolism in T Lymphocyte Differentiation and Survival.
Q58114531The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor
Q39032994The Therapeutic Potential of T Cell Metabolism.
Q39237471The bioenergetics of inflammation: insights into obesity and type 2 diabetes.
Q89915575The immunologic Warburg effect: Evidence and therapeutic opportunities in autoimmunity
Q47617054The impact of cellular metabolism on chromatin dynamics and epigenetics
Q96304966The numbers of peripheral regulatory T cells are reduced in patients with psoriatic arthritis and are restored by low-dose interleukin-2
Q38984914The obesity-related pathology and Th17 cells.
Q39036066The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome
Q49853005The spectrum of T cell metabolism in health and disease.
Q38988403Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.
Q55365838Thymic Program Directing the Functional Development of γδT17 Cells.
Q92409730Transcription Factor IRF4 Dysfunction Affects the Immunosuppressive Function of Treg Cells in Patients with Primary Immune Thrombocytopenia
Q49790388Transcriptional factor ICER promotes glutaminolysis and the generation of Th17 cells.
Q48638999Tumor-associated myeloid cells: new understandings on their metabolic regulation and their influence in cancer immunotherapy.
Q55478869Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction.
Q52727826Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1.
Q93208179mTOR Inhibitor Everolimus in Regulatory T Cell Expansion for Clinical Application in Transplantation
Q28081442mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging
Q54966043mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis.

Search more.