Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

scientific article published on 26 August 2015

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELL.2015.08.016
P932PMC publication ID4864363
P698PubMed publication ID26321679

P50authorMichael D. BuckQ55476775
P2093author name stringDavid O'Sullivan
Takuro Noguchi
Jing Qiu
Robert D Schreiber
Chih-Hao Chang
Qiongyu Chen
Gerritje J W van der Windt
Matthew M Gubin
Elena Tonc
Erika L Pearce
Jonathan D Curtis
Edward J Pearce
Mariel Gindin
P2860cites workmTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machineryQ24302549
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanismsQ24534904
Posttranscriptional control of T cell effector function by aerobic glycolysisQ24606942
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanomaQ24629841
The PD-1 pathway in tolerance and autoimmunityQ24633549
mTOR signaling in growth control and diseaseQ24634174
Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammationQ24682128
Fueling immunity: insights into metabolism and lymphocyte functionQ27025284
T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironmentQ38072512
Exploiting CTLA-4, PD-1 and PD-L1 to reactivate the host immune response against cancer.Q38091267
Immune modulation in cancer with antibodiesQ38159801
Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment.Q38218127
Targeting T cell metabolism for therapyQ38324388
Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cellsQ39239858
Bioenergetic profile experiment using C2C12 myoblast cellsQ39614847
Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cellsQ41427795
Alerting the immune system via stromal cells is central to the prevention of tumor growthQ41913328
Mouse cerebellar granule neurons arrest the proliferation of human and rodent astrocytoma cells in vitroQ42804262
Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.Q42829358
Fine-tuning CD8(+) T cell functional responses: mTOR acts as a rheostat for regulating CD8(+) T cell proliferation, survival and differentiation?Q42941158
PD-L1 expression by neurons nearby tumors indicates better prognosis in glioblastoma patientsQ47679044
Neuro-oncology: Glioblastoma prognosis linked to neuronal PD-L1 expression in tumour-adjacent tissue.Q49022924
Friends not foes: CTLA-4 blockade and mTOR inhibition cooperate during CD8+ T cell priming to promote memory formation and metabolic readiness.Q50755650
Tumor-reactive CD8+ early effector T cells identified at tumor site in primary and metastatic melanoma.Q51036583
Inhibitory effect of tumor cell-derived lactic acid on human T cellsQ79666516
Nivolumab plus ipilimumab in advanced melanomaQ27852310
Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in MelanomaQ27860650
Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced CancerQ27860857
On the Origin of Cancer CellsQ27861025
Improved Survival with Ipilimumab in Patients with Metastatic MelanomaQ27861062
PD-1 and its ligands in tolerance and immunityQ28131650
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasionQ28131654
Inhibition of T cell proliferation by macrophage tryptophan catabolismQ28142922
Why do cancers have high aerobic glycolysis?Q28290710
T cell exhaustionQ29620463
Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteineQ33584867
Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironmentQ33606150
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophagesQ34071063
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impairedQ34080914
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activationQ34242691
Indoleamine 2,3 dioxygenase and metabolic control of immune responsesQ34308495
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.Q34412152
The CD28 signaling pathway regulates glucose metabolismQ34525357
The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infectionQ34734469
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigensQ34788858
Progressive differentiation and selection of the fittest in the immune responseQ35014086
Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patientsQ35015778
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammationQ35242438
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.Q35404457
Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastomaQ35815273
Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growthQ35849703
Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cellsQ36365491
Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapyQ36829161
PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cellsQ36890941
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferationQ36907933
Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.Q36995837
Creating immune privilege: active local suppression that benefits friends, but protects foes.Q37026641
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoeditingQ37418530
Diversity in CD8(+) T cell differentiation.Q37508408
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1229-1241
P577publication date2015-08-27
P1433published inCellQ655814
P1476titleMetabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
P478volume162

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Q89640431Memory T cells delay the progression of atherosclerosis via AMPK signaling pathway
Q39313220MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells
Q96348555Met-Flow, a strategy for single-cell metabolic analysis highlights dynamic changes in immune subpopulations
Q50133232Metabolic Barriers to T Cell Function in Tumors.
Q61448742Metabolic Checkpoints in Differentiation of Helper T Cells in Tissue Inflammation
Q58797278Metabolic Checkpoints: Novel Avenues for Immunotherapy of Cancer
Q39265746Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy.
Q90623679Metabolic Factors Contribute to T-cell Inhibition in the Ovarian Cancer Ascites
Q92736070Metabolic Fitness and Plasticity in Cancer Progression
Q39197674Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment
Q39286043Metabolic Instruction of Immunity.
Q39452100Metabolic Interactions in the Tumor Microenvironment
Q91656884Metabolic Plasticity and Epithelial-Mesenchymal Transition
Q90642651Metabolic Plasticity in Chemotherapy Resistance
Q50217787Metabolic Regulation of T Cell Immunity.
Q39418546Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy
Q88693147Metabolic Regulation of Tregs in Cancer: Opportunities for Immunotherapy
Q42339950Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation
Q64245167Metabolic Reprogramming in Breast Cancer and Its Therapeutic Implications
Q60046968Metabolic Reprogramming of Non-Hodgkin's B-Cell Lymphomas and Potential Therapeutic Strategies
Q91310907Metabolic Stress Triggers Immune Escape by Tumors
Q58750642Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1
Q99595178Metabolic and epigenetic regulation of T-cell exhaustion
Q92932414Metabolic and functional reprogramming of myeloid-derived suppressor cells and their therapeutic control in glioblastoma
Q26765256Metabolic communication in tumors: a new layer of immunoregulation for immune evasion
Q98196854Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy
Q92578624Metabolic coordination of T cell quiescence and activation
Q48102749Metabolic exhaustion in infection, cancer and autoimmunity.
Q92664771Metabolic influence on macrophage polarization and pathogenesis
Q92023481Metabolic interventions in the immune response to cancer
Q38850162Metabolic regulation of immune responses: therapeutic opportunities
Q39143778Metabolic reprogramming and apoptosis sensitivity: defining the contours of a T cell response.
Q39378337Metabolic reprogramming in the tumour microenvironment: a hallmark shared by cancer cells and T lymphocytes
Q39343660Metabolic rewiring in mutant Kras lung cancer
Q47759599Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications.
Q64950563Metabolic stress in cancer cells induces immune escape through a PI3K-dependent blockade of IFNγ receptor signaling.
Q40436359Metabolic tug-of-war in tumors results in diminished T cell antitumor immunity
Q26765348Metabolism Is Central to Tolerogenic Dendritic Cell Function
Q90854388Metabolism as a guiding force for immunity
Q46291182Metabolism in cancer metastasis: bioenergetics, biosynthesis, and beyond
Q97424076Metabolism of immune cells in cancer
Q89980729Metabolism of pancreatic cancer: paving the way to better anticancer strategies
Q39367096Metabolism shapes the tumor microenvironment
Q88016005Metabolites, genome organization, and cellular differentiation gene programs
Q90214418Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects
Q53037025Methods to Evaluate the Antitumor Activity of Immune Checkpoint Inhibitors in Preclinical Studies.
Q37288070MicroRNAs and PIWI-interacting RNAs in oncology
Q58796751Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies
Q94481939Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models
Q93078150Mitochondria as central hub of the immune system
Q39689532Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.
Q92296866Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function
Q47770635Mitochondrial Priming by CD28.
Q90413933Mitochondrial Redox Hubs as Promising Targets for Anticancer Therapy
Q64060146Mitochondrial Retrograde Signalling and Metabolic Alterations in the Tumour Microenvironment
Q39410087Mitochondrial control of immunity: beyond ATP.
Q33798098Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma
Q90860192Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance
Q57842307Mitochondrial metabolism and cancer
Q38996832Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway
Q55420715Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression.
Q57232070Mutations and PD-1 Inhibitor Resistance in -Mutant Lung Adenocarcinoma
Q92556947NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in Cancer
Q90733162NK Cell Metabolism and Tumor Microenvironment
Q60947027Natural Killer Cell Education Is Associated With a Distinct Glycolytic Profile
Q92637629Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
Q92445830Neutrophil Metabolic Shift during their Lifecycle: Impact on their Survival and Activation
Q92344203New Insights about the Wnt/β-Catenin Signaling Pathway in Primary Bone Tumors and Their Microenvironment: A Promising Target to Develop Therapeutic Strategies?
Q90644432New concepts in feedback regulation of glucose metabolism
Q90008739New insight on the correlation of metabolic status on 18F-FDG PET/CT with immune marker expression in patients with non-small cell lung cancer
Q93002697New therapeutic targets for cancer: the interplay between immune and metabolic checkpoints and gut microbiota
Q44101088Notable advances 2015.
Q39347426Novel "Elements" of Immune Suppression within the Tumor Microenvironment
Q56888845Novel Effector Phenotype of Tim-3 Regulatory T Cells Leads to Enhanced Suppressive Function in Head and Neck Cancer Patients
Q86113118Nutrient Competition: A New Axis of Tumor Immunosuppression
Q39456875Nutrient Exploitation within the Tumor-Stroma Metabolic Crosstalk
Q37689449Nutrient and Metabolic Sensing in T Cell Responses
Q38974085Nutrients and the microenvironment to feed a T cell army
Q90212537Obesity and CD8 T cell metabolism: Implications for anti-tumor immunity and cancer immunotherapy outcomes
Q39178061Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies.
Q90721907Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia
Q37017190Overcoming barriers to effective immunotherapy: MDSCs, TAMs, and Tregs as mediators of the immunosuppressive microenvironment in head and neck cancer.
Q46272404Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor.
Q34538613Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Q40124899PD-1 Checkpoint Blockade in Combination with an mTOR Inhibitor Restrains Hepatocellular Carcinoma Growth Induced by Hepatoma Cell-Intrinsic PD-1.
Q99550883PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and target tumor cells within the tumor
Q47120629PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?
Q28075712PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations
Q99564986PD-L1 controls cancer pyroptosis
Q52731766PD-L1 inhibitors in the pipeline: Promise and progress.
Q41693775PD-L1 is an activation-independent marker of brown adipocytes
Q47101171PD-L1/PD-1: new kid on the "immune metabolic" block.
Q41714574PDL1 And LDHA act as ceRNAs in triple negative breast cancer by regulating miR-34a
Q64122894PD‑L1 promotes head and neck squamous cell carcinoma cell growth through mTOR signaling
Q37547644PPARδ as a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance
Q90614041Pharmacological Targeting of GLUT1 to Control Autoreactive T Cell Responses
Q49788536Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells.
Q92155161Phosphoenolpyruvate from Glycolysis and PEPCK Regulate Cancer Cell Fate by Altering Cytosolic Ca2
Q92304285Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation
Q48306408Potential Utility of FDG PET-CT as a Non-invasive Tool for Monitoring Local Immune Responses
Q92921569Pre-Disease and Pre-Surgery BMI, Weight Loss and Sarcopenia Impact Survival of Resected Lung Cancer Independently of Tumor Stage
Q90576088Precursor exhausted T cells: key to successful immunotherapy?
Q37196014Primary and metastatic tumor dormancy as a result of population heterogeneity
Q92617618Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity
Q88506865Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway
Q37042232Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality
Q47094138Programmed death-ligand 1 expression correlates with diminished CD8+ T cell infiltration and predicts poor prognosis in anal squamous cell carcinoma patients
Q39198154Prospects for combining targeted and conventional cancer therapy with immunotherapy
Q26752535Pyruvate Kinase M2: A Potential Target for Regulating Inflammation
Q46302218Reactive oxygen species (ROS) are a key determinant of cancer's metabolic phenotype
Q42198803Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer
Q30252210Recent insights into the implications of metabolism in plasmacytoid dendritic cell innate functions: Potential ways to control these functions
Q94503527Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion
Q99630278Reciprocal change in Glucose metabolism of Cancer and Immune Cells mediated by different Glucose Transporters predicts Immunotherapy response
Q39273837Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries
Q52725238Regulation and Function of the PD-L1 Checkpoint.
Q54952659Regulation of Immune Cell Functions by Metabolic Reprogramming.
Q39322285Regulation of Metabolic Activity by p53.
Q43166710Regulation of mTOR, Metabolic Fitness, and Effector Functions by Cytokines in Natural Killer Cells.
Q94461827Regulation of sister chromatid cohesion by nuclear PD-L1
Q48231687Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition
Q38928127Regulatory circuits of T cell function in cancer
Q92058622Relationship between PD-L1 expression and 18F-FDG uptake in gastric cancer
Q33917658Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?
Q59798737Resident-Memory T Cells in Tissue-Restricted Immune Responses: For Better or Worse?
Q92132117Resistance to PD-L1/PD-1 Blockade Immunotherapy. A Tumor-Intrinsic or Tumor-Extrinsic Phenomenon?
Q38809776Reversing T-cell Dysfunction and Exhaustion in Cancer
Q33732986Revisiting the hallmarks of cancer
Q41934141Role of PD-1 in Immunity and Diseases
Q101216971Roles of mitochondria in the hallmarks of metastasis
Q37491480S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.
Q38700564STAT3 Induces Immunosuppression by Upregulating PD-1/PD-L1 in HNSCC.
Q47607473Secretory Autophagy in Cancer-Associated Fibroblasts Promotes Head and Neck Cancer Progression and Offers a Novel Therapeutic Target
Q89969652Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy
Q90286267Sepsis Immunometabolism: From Defining Sepsis to Understanding How Energy Production Affects Immune Response
Q37688926Serum depletion induced cancer stem cell-like phenotype due to nitric oxide synthesis in oncogenic HRas transformed cells
Q92002600Shedding New Light on Cancer Metabolism: A Metabolic Tightrope Between Life and Death
Q90589491Signaling networks in immunometabolism
Q47372804Signaling pathways and immune evasion mechanisms in classical Hodgkin lymphoma
Q49989121Signaling pathways and immune evasion mechanisms in classical Hodgkin lymphoma.
Q39418532Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors
Q38645730Similarities in the Metabolic Reprogramming of Immune System and Endothelium
Q99637273Single-cell metabolic profiling of human cytotoxic T cells
Q90727444Starvation and Pseudo-Starvation as Drivers of Cancer Metastasis through Translation Reprogramming
Q26767514Starved and Asphyxiated: How Can CD8(+) T Cells within a Tumor Microenvironment Prevent Tumor Progression
Q91981643Strategies to Interfere with Tumor Metabolism through the Interplay of Innate and Adaptive Immunity
Q39190194Strategies to Target Glucose Metabolism in Tumor Microenvironment on Cancer by Flavonoids
Q38872869Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers
Q64055421Stressed: The Unfolded Protein Response in T Cell Development, Activation, and Function
Q92404807Striking a Balance-Cellular and Molecular Drivers of Memory T Cell Development and Responses to Chronic Stimulation
Q99565366Study on metastasis inhibition of Kejinyan decoction on lung cancer by affecting tumor microenvironment
Q46259330Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity.
Q38752567Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia
Q89682571Surgical Wound Fluids from Patients with Breast Cancer Reveal Similarities in the Biological Response Induced by Intraoperative Radiation Therapy and the Radiation-Induced Bystander Effect-Transcriptomic Approach
Q99555096Systemic Immunometabolism: Challenges and Opportunities
Q90162757T Cell Activation Depends on Extracellular Alanine
Q55000833T Cell Calcium Signaling Regulation by the Co-Receptor CD5.
Q89967564T Cell Dysfunction and Exhaustion in Cancer
Q92405303T Cell Dysfunction in Cancer Immunity and Immunotherapy
Q52596337T Cell Dysfunction in Cancer.
Q97539453T Cell Metabolism in Cancer Immunotherapy
Q92932341T lymphocytes against solid malignancies: winning ways to defeat tumours
Q52625023T-Cell Dysfunction in Glioblastoma: Applying a New Framework.
Q59341026T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses
Q39183146T-cell Metabolism as a Target to Control Autoreactive T Cells in β-Cell Autoimmunity
Q38915095T-cell metabolism governing activation, proliferation and differentiation; a modular view
Q64100384TAMing pancreatic cancer: combat with a double edged sword
Q58586565TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation
Q91620971TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis
Q37277182TGF-β and VEGF cooperatively control the immunotolerant tumor environment and the efficacy of cancer immunotherapies
Q92890188TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
Q52649195TLR-mediated metabolic reprogramming in the tumor microenvironment: potential novel strategies for cancer immunotherapy.
Q57815155TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy
Q52354472TUMOR CROSSTALK NETWORKS PROMOTE GROWTH AND SUPPORT IMMUNE EVASION IN PANCREATIC CANCER.
Q38872235Taming Tumor Glycolysis and Potential Implications for Immunotherapy
Q91536702Targeted Metabolic Reprogramming to Improve the Efficacy of Oncolytic Virus Therapy
Q60950041Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy
Q92642526Targeting Cellular Metabolism Modulates Head and Neck Oncogenesis
Q58694964Targeting Chemokines and Chemokine Receptors in Melanoma and Other Cancers
Q91782554Targeting Glucose Metabolism to Enhance Immunotherapy: Emerging Evidence on Intermittent Fasting and Calorie Restriction Mimetics
Q58801754Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy
Q90098490Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy
Q52661722Targeting Tumor Metabolism: A New Challenge to Improve Immunotherapy.
Q91826248Targeting aerobic glycolysis by dichloroacetate improves Newcastle disease virus-mediated viro-immunotherapy in hepatocellular carcinoma
Q50026335Targeting immuno-metabolism to improve anti-cancer therapies.
Q39149196Targeting neoantigens to augment antitumour immunity
Q91598122Targeting the tumor microenvironment and T cell metabolism for effective cancer immunotherapy
Q38805897Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy
Q38710513Temperature induces significant changes in both glycolytic reserve and mitochondrial spare respiratory capacity in colorectal cancer cell lines
Q64237577The 'Achilles Heel' of Metabolism in Renal Cell Carcinoma: Glutaminase Inhibition as a Rational Treatment Strategy
Q98237511The AKT-independent MET-V-ATPase-MTOR axis suppresses liver cancer vaccination
Q60914167The Adaptive Complexity of Cancer
Q92074035The Binding of PD-L1 and Akt Facilitates Glioma Cell Invasion Upon Starvation via Akt/Autophagy/F-Actin Signaling
Q89965531The Emerging Roles of Endoplasmic Reticulum Stress in Balancing Immunity and Tolerance in Health and Diseases: Mechanisms and Opportunities
Q38718460The Exportin-1 Inhibitor Selinexor Exerts Superior Antitumor Activity when Combined with T-Cell Checkpoint Inhibitors
Q88494418The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop
Q41615240The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti-PD-1 Response in Patients with Renal Cell Carcinoma
Q41340368The Lymphatic System: Integral Roles in Immunity
Q90043597The Metabolic Remodelling in Lung Cancer and Its Putative Consequence in Therapy Response
Q90705241The Metabolic Requirements of Th2 Cell Differentiation
Q39538318The PD-1/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia.
Q49463699The Potential Role of circRNA in Tumor Immunity Regulation and Immunotherapy.
Q39130457The Principles of Engineering Immune Cells to Treat Cancer
Q61449923The Prognostic and Therapeutic Value of PD-L1 in Glioma
Q57789211The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity
Q90162934The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality
Q39518049The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction
Q92642235The Tumor Microenvironment in Colorectal Cancer Therapy
Q39169603The Unique Molecular and Cellular Microenvironment of Ovarian Cancer
Q34509467The Warburg Effect: How Does it Benefit Cancer Cells?
Q57167592The big picture: exploring the metabolic cross-talk in cancer
Q38828825The biology and function of fibroblasts in cancer
Q49826396The biology and management of non-small cell lung cancer.
Q92086089The canonical TGF-β/Smad signalling pathway is involved in PD-L1-induced primary resistance to EGFR-TKIs in EGFR-mutant non-small-cell lung cancer
Q52641713The cellular metabolic landscape in the tumor milieu regulates the activity of myeloid infiltrates.
Q58561576The clinical role of the TME in solid cancer
Q38968957The convergence of senescence and nutrient sensing during lymphocyte ageing
Q49843616The critical roles of activated stellate cells-mediated paracrine signaling, metabolism and onco-immunology in pancreatic ductal adenocarcinoma.
Q99565360The crosstalk between circular RNAs and the tumor microenvironment in cancer metastasis
Q47678849The diverse functions of the PD1 inhibitory pathway
Q58694628The elevated glutaminolysis of bladder cancer and T cells in a simulated tumor microenvironment contributes to the up-regulation of PD-L1 expression by interferon-γ
Q28079015The ever-expanding role of HIF in tumour and stromal biology
Q47205727The fibrotic tumor stroma
Q98946913The fuel and engine: The roles of reprogrammed metabolism in metastasis of primary liver cancer
Q95936578The future of cancer immunotherapy: microenvironment-targeting combinations
Q98665168The hidden side of PD-L1
Q48181172The hypoxic tumour microenvironment
Q26745842The immune microenvironment in Hodgkin lymphoma: T cells, B cells, and immune checkpoints
Q47617054The impact of cellular metabolism on chromatin dynamics and epigenetics
Q60934870The impact of senescence-associated T cells on immunosenescence and age-related disorders
Q88159540The influence of hypoxia and IFN-γ on the proteome and metabolome of therapeutic mesenchymal stem cells
Q92314188The influence of microenvironment on tumor immunotherapy
Q39328710The interplay between metabolic remodeling and immune regulation in glioblastoma
Q57067759The intracellular signalosome of PD-L1 in cancer cells
Q39023597The intragraft microenvironment as a central determinant of chronic rejection or local immunoregulation/tolerance
Q89507027The metabolic axis of macrophage and immune cell polarization
Q36879974The multifaceted role of CD4(+) T cells in CD8(+) T cell memory
Q29694341The multifaceted roles of fatty acid synthesis in cancer
Q64100953The prognostic value of PKM2 and its correlation with tumour cell PD-L1 in lung adenocarcinoma
Q57022016The proto-oncogene Bcl3 induces immune checkpoint PD-L1 expression, mediating proliferation of ovarian cancer cells
Q92107874The role of Wnt signaling pathway in tumor metabolic reprogramming
Q52680707The role of the mitochondria and the endoplasmic reticulum contact sites in the development of the immune responses.
Q49853005The spectrum of T cell metabolism in health and disease.
Q94524554The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy
Q99711547To Remember or to Forget: The Role of Good and Bad Memories in Adoptive T Cell Therapy for Tumors
Q92110394Topical Diclofenac Reprograms Metabolism and Immune Cell Infiltration in Actinic Keratosis
Q50217785Transcriptional Regulation of T Cell Metabolism Reprograming.
Q28077647Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity
Q92282117Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response
Q90043556Tumor Microenvironment - Selective Pressures Boosting Cancer Progression
Q64122311Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma
Q88748954Tumor cell-intrinsic PD-L1 promotes tumor-initiating cell generation and functions in melanoma and ovarian cancer
Q47678837Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma.
Q96167005Tumor microenvironmental influences on dendritic cell and T cell function: A focus on clinically relevant immunologic and metabolic checkpoints
Q39441385Tumor-Host Cell Interactions in Ovarian Cancer: Pathways to Therapy Failure
Q37409946Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity
Q38743564Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma.
Q30830664Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine
Q90746399Tumor-intrinsic CD47 signal regulates glycolysis and promotes colorectal cancer cell growth and metastasis
Q58611503Tumors sweeten macrophages with acids
Q47772621Tumour acidosis: from the passenger to the driver's seat.
Q86239752Tumour immunology: An exhausting metabolic competition
Q37627771Tumour microenvironment factors shaping the cancer metabolism landscape.
Q59799202Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression
Q96945876Turning Cold into Hot: Firing up the Tumor Microenvironment
Q39130440Understanding the Intersections between Metabolism and Cancer Biology
Q52314225Unraveling the Complex Interplay Between T Cell Metabolism and Function.
Q37058110Utilizing cell-based therapeutics to overcome immune evasion in hematologic malignancies
Q93229458Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity
Q54185869Warburg meets epigenetics.
Q37224595Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma.
Q57491938mTOR Regulation of Glycolytic Metabolism in T Cells
Q93053344mTOR signalling and cellular metabolism are mutual determinants in cancer
Q38951050mTOR-Mediated Regulation of Dendritic Cell Differentiation and Function
Q89540099miR-155 Overexpression in OT-1 CD8+ T Cells Improves Anti-Tumor Activity against Low-Affinity Tumor Antigen

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