New therapeutic targets for cancer: the interplay between immune and metabolic checkpoints and gut microbiota

scientific article published on 27 August 2019

New therapeutic targets for cancer: the interplay between immune and metabolic checkpoints and gut microbiota is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1186/S40169-019-0241-X
P932PMC publication ID6715761
P698PubMed publication ID31468283

P2093author name stringBabita Agrawal
P2860cites workMolecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulationQ24292211
MUC1: a multifunctional cell surface component of reproductive tissue epitheliaQ24633038
T cell activationQ24658051
Targeting the mTOR signaling network for cancer therapyQ24658334
Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic TargetingQ26742012
A Metabolic Immune Checkpoint: Adenosine in Tumor MicroenvironmentQ26749571
CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their InhibitionQ26777563
Molecular and cellular insights into T cell exhaustionQ26800047
Molecular mechanisms of T cell co-stimulation and co-inhibitionQ26864888
Innate and adaptive immune cells in the tumor microenvironmentQ27008342
The blockade of immune checkpoints in cancer immunotherapyQ27860852
Immunity, Inflammation, and CancerQ27861048
Hypoxia-inducible factors regulate T cell metabolism and functionQ28081650
5-Fluorouracil: mechanisms of action and clinical strategiesQ28201937
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenaseQ28204166
Structure and function of the cell surface (tethered) mucinsQ28248285
Glycolysis inhibition for anticancer treatmentQ28256222
The extracellular matrix: a dynamic niche in cancer progressionQ29617793
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4Q29619280
T cell exhaustionQ29620463
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK CellsQ30313865
Cancer associated fibroblasts in cancer pathogenesisQ33664004
MUC1: a multifaceted oncoprotein with a key role in cancer progressionQ33880143
Failure of cancer vaccines: the significant limitations of this approach to immunotherapyQ34011280
What are the hallmarks of cancer?Q34107625
The extracellular matrix at a glanceQ34152843
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.Q34429912
Translating tumor antigens into cancer vaccinesQ34484042
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganismsQ35024882
Angiogenic and angiostatic factors in the molecular control of angiogenesis.Q35191425
Recurrent antibiotic exposure may promote cancer formation--Another step in understanding the role of the human microbiota?Q35764221
Inhibitory Receptors Beyond T Cell Exhaustion.Q35783318
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacyQ35833912
Obesity and the role of adipose tissue in inflammation and metabolismQ36392619
Anticancer agents that counteract tumor glycolysis.Q36452381
Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancerQ36597391
Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1αQ36921665
Lack of Muc1-regulated beta-catenin stability results in aberrant expansion of CD11b+Gr1+ myeloid-derived suppressor cells from the bone marrowQ37249025
Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8 T CellsQ37402534
Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanomaQ37542216
Cancer-associated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-β signallingQ37559049
The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers.Q37612156
Role of tumor microenvironment in tumorigenesisQ37738074
Hypoxia and hypoxia inducible factors in cancer stem cell maintenanceQ37768064
Fibroblasts and myofibroblasts: what are we talking about?Q37836316
Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunityQ38031978
Coinhibitory molecules in autoimmune diseases.Q38045307
Infection and cancer: revaluation of the hygiene hypothesisQ38093811
Targeting lactate metabolism for cancer therapeuticsQ38133722
Therapeutic strategies impacting cancer cell glutamine metabolismQ38139096
Tolerance and exhaustion: defining mechanisms of T cell dysfunctionQ38161101
TGF-beta in CAF-mediated tumor growth and metastasisQ38177501
MUC1: a novel metabolic master regulatorQ38177983
Adipocytes and preadipocytes promote the proliferation of colon cancer cells in vitro.Q38306509
MUC1 (CD227): a multi-tasked moleculeQ38570769
Immune Checkpoint Inhibitors: New Insights and Current Place in Cancer TherapyQ38615337
PD-L1 expression is regulated by hypoxia inducible factor in clear cell renal cell carcinomaQ38788703
The biology and function of fibroblasts in cancerQ38828825
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.Q38837469
Metformin: An anti-diabetic drug to fight cancerQ38976526
Systematic Pan-Cancer Analysis Reveals Immune Cell Interactions in the Tumor Microenvironment.Q38996594
Adipose-derived stromal cells inhibit prostate cancer cell proliferation inducing apoptosisQ39010508
Interplay between Immune Checkpoint Proteins and Cellular Metabolism.Q39155250
Metabolic Hallmarks of Tumor and Immune Cells in the Tumor MicroenvironmentQ39197674
The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance.Q39356609
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epitheliumQ40923257
T cell activation pathways: B7, LFA-3, and ICAM-1 shape unique T cell profiles.Q41134187
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer ProgressionQ41437712
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitmentQ42593305
Mutagenicity of nitric oxide-releasing compounds in Escherichia coli: effect of superoxide generation and evidence for two mutagenic mechanismsQ43722177
MUC1 mucin is expressed on human T-regulatory cells: function in both co-stimulation and co-inhibitionQ43828225
SnapShot: Immune Checkpoint Inhibitors.Q45939025
Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppressionQ46215374
PD-L1/PD-1: new kid on the "immune metabolic" block.Q47101171
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients.Q47447695
Discovery of IDO1 Inhibitors: From Bench to BedsideQ47547812
The hypoxic tumour microenvironmentQ48181172
Metabolic Barriers to T Cell Function in Tumors.Q50133232
MUC1 is a novel costimulatory molecule of human T cells and functions in an AP-1-dependent manner.Q50961667
Hypoxia-Driven Adenosine Accumulation: A Crucial Microenvironmental Factor Promoting Tumor Progression.Q51554659
Regulation and Function of the PD-L1 Checkpoint.Q52725238
Combining vaccines and immune checkpoint inhibitors to prime, expand, and facilitate effective tumor immunotherapyQ56890639
Hyperprogressive disease: recognizing a novel pattern to improve patient managementQ58561264
Updates in the Clinical Development of Epacadostat and Other Indoleamine 2,3-Dioxygenase 1 Inhibitors (IDO1) for Human CancersQ58584052
Targeting Multiple Receptors to Increase Checkpoint Blockade EfficacyQ60920815
Elevated soluble MUC1 levels and decreased anti-MUC1 antibody levels in patients with multiple myelomaQ73119286
PD-1: an inhibitory immunoreceptor involved in peripheral toleranceQ73807451
Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2Q74033284
Expression of MUC1 mucin on activated human T cells: implications for a role of MUC1 in normal immune regulationQ77343398
Overexpression of MUC1 reconfigures the binding properties of tumor cellsQ77357803
MUC1 epithelial mucin (CD227) is expressed by activated dendritic cellsQ78366913
The microbiome and cancerQ87632019
The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer ImmunotherapyQ88318275
mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T CellsQ89047059
Adipocytes Promote Early Steps of Breast Cancer Cell Dissemination via Interleukin-8Q90930607
Cancer statistics, 2019Q90941571
P433issue1
P304page(s)23
P577publication date2019-08-27
P1433published inClinical and translational medicineQ27724586
P1476titleNew therapeutic targets for cancer: the interplay between immune and metabolic checkpoints and gut microbiota
P478volume8

Reverse relations

cites work (P2860)
Q91642636Bugs as Drugs, potential self-regenerated innovative cancer therapeutics approach for global health
Q97524171Ganoderma lucidum fruiting body extracts inhibit colorectal cancer by inducing apoptosis, autophagy, and G0/G1 phase cell cycle arrest in vitro and in vivo
Q92331758Roles of transforming growth factor-β and phosphatidylinositol 3-kinase isoforms in integrin β1-mediated bio-behaviors of mouse lung telocytes
Q90694690Soy Metabolism by Gut Microbiota from Patients with Precancerous Intestinal Lesions

Search more.