Targeting ribosomal S6 kinases/Y-box binding protein-1 signaling improves cellular sensitivity to taxane in prostate cancer

scientific article published on 12 April 2014

Targeting ribosomal S6 kinases/Y-box binding protein-1 signaling improves cellular sensitivity to taxane in prostate cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/PROS.22799
P698PubMed publication ID24729449
P5875ResearchGate publication ID261569984

P50authorMasaki ShiotaQ60390038
Ario TakeuchiQ123738398
P2093author name stringKatsunori Tatsugami
Kenjiro Imada
Seiji Naito
Takeshi Uchiumi
Akira Yokomizo
Eiji Kashiwagi
Junichi Inokuchi
Momoe Itsumi
P2860cites workInteraction between docetaxel resistance and castration resistance in prostate cancer: implications of Twist1, YB-1, and androgen receptorQ39138335
Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancersQ39335656
Androgen receptor signaling regulates cell growth and vulnerability to doxorubicin in bladder cancerQ39345959
MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibitionQ39411394
Clusterin is a critical downstream mediator of stress-induced YB-1 transactivation in prostate cancerQ39460386
Twist1 and Y‐box‐binding protein‐1 promote malignant potential in bladder cancer cellsQ39630735
Novel therapeutic strategies following docetaxel-based chemotherapy in castration-resistant prostate cancer.Q39683668
Genotoxic stress-induced nuclear localization of oncoprotein YB-1 in the absence of proteolytic processing.Q39786200
Programmed cell death protein 4 down-regulates Y-box binding protein-1 expression via a direct interaction with Twist1 to suppress cancer cell growthQ39868606
The tumor suppressor DAP kinase is a target of RSK-mediated survival signalingQ40364004
Increased nuclear localization of transcription factor Y-box binding protein 1 accompanied by up-regulation of P-glycoprotein in breast cancer pretreated with paclitaxel.Q50744999
Mutual regulation between Raf/MEK/ERK signaling and Y-box-binding protein-1 promotes prostate cancer progression.Q50848979
Dual pathways for nuclear factor kappaB activation by angiotensin II in vascular smooth muscle: phosphorylation of p65 by IkappaB kinase and ribosomal kinaseQ64378324
Rsk1 mediates a MEK-MAP kinase cell survival signalQ22253213
C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survivalQ24291845
The RSK family of kinases: emerging roles in cellular signallingQ24315679
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistanceQ24645668
The selectivity of protein kinase inhibitors: a further updateQ24654622
Pro-survival and anti-apoptotic properties of androgen receptor signaling by oxidative stress promote treatment resistance in prostate cancerQ26852582
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanismsQ28137802
Nuclear translocation of the Y-box binding protein by ultraviolet irradiationQ28257567
Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinaseQ28283499
Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancerQ29616123
Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancerQ29616218
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trialQ29620155
RSK in tumorigenesis: connections to steroid signalingQ30433106
Ribosomal S6 kinase 2 is a key regulator in tumor promoter induced cell transformationQ30437044
Phosphorylation of cold shock domain/Y-box proteins by ERK2 and GSK3beta and repression of the human VEGF promoterQ33292543
Targeting RSK: an overview of small molecule inhibitorsQ33376012
Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistanceQ33766973
Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cellsQ33775667
Small molecule inhibitors targeting the "achilles' heel" of androgen receptor activityQ33810134
Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viabilityQ34117426
Direct roles of the signaling kinase RSK2 in Cdc25C activation during Xenopus oocyte maturationQ34359234
The pleiotropic functions of the Y-box-binding protein, YB-1.Q35158110
Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiationQ35558949
An update on androgen deprivation therapy for prostate cancerQ36289952
Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cellsQ37131331
Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.Q37837732
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.Q37865381
Regulation and function of the RSK family of protein kinasesQ37970380
Castration-resistant prostate cancer: novel therapeutics pre- or post- taxane administration.Q38091759
YB-1 is upregulated during prostate cancer tumor progression and increases P-glycoprotein activityQ38343224
P433issue8
P304page(s)829-838
P577publication date2014-04-12
P1433published inThe ProstateQ7758608
P1476titleTargeting ribosomal S6 kinases/Y-box binding protein-1 signaling improves cellular sensitivity to taxane in prostate cancer
P478volume74

Reverse relations

cites work (P2860)
Q38778712A novel EGR-1 dependent mechanism for YB-1 modulation of paclitaxel response in a triple negative breast cancer cell line
Q58697074Collateral resistance to taxanes in enzalutamide-resistant prostate cancer through aberrant androgen receptor and its variants
Q38924997Differential expression of the multidrug resistance 1 (MDR1) protein in prostate cancer cells is independent from anticancer drug treatment and Y box binding protein 1 (YB-1) activity
Q42288454GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance.
Q35038605High expression of Y-box-binding protein 1 is associated with local recurrence and predicts poor outcome in patients with colorectal cancer
Q36299754Inhibition of RSK with the novel small-molecule inhibitor LJI308 overcomes chemoresistance by eliminating cancer stem cells
Q64246203KIFC1 Inhibitor CW069 Induces Apoptosis and Reverses Resistance to Docetaxel in Prostate Cancer
Q47678215Polypharmacology-based ceritinib repurposing using integrated functional proteomics
Q38795167Silodosin inhibits prostate cancer cell growth via ELK1 inactivation and enhances the cytotoxic activity of gemcitabine
Q92619546TUBB3 Reverses Resistance to Docetaxel and Cabazitaxel in Prostate Cancer

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