TLR4 induces tumor growth and inhibits paclitaxel activity in MyD88-positive human ovarian carcinoma in vitro

scientific article published on 16 December 2013

TLR4 induces tumor growth and inhibits paclitaxel activity in MyD88-positive human ovarian carcinoma in vitro is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3892/OL.2013.1759
P932PMC publication ID3919821
P698PubMed publication ID24527095
P5875ResearchGate publication ID260196892

P2093author name stringRong Gao
Xiu-Gui Sheng
Yong-Sheng Gao
An-Cong Wang
Feng-Xia Wu
Nai-Fu Liu
Zhi-Fang Ma
Yue-Bing Ma
P2860cites workUnresponsiveness of MyD88-deficient mice to endotoxinQ78093558
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 GeneQ22299417
Toll-like receptorsQ27860671
Pathogen recognition and innate immunityQ27861084
A human homologue of the Drosophila Toll protein signals activation of adaptive immunityQ28131769
Mycobacterium tuberculosis lipoarabinomannan-mediated IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophagesQ28279932
Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6Q28292248
Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4Q28611075
MyD88 predicts chemoresistance to paclitaxel in epithelial ovarian cancer.Q33302912
Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group studyQ33348987
Regulation of death receptor-mediated apoptosis pathwaysQ34117899
Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifoliaQ34235776
Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasisQ34285076
ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin toleranceQ34303629
The activation of Akt/PKB signaling pathway and cell survival.Q34405519
Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokineQ34947284
Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugsQ36085634
Taxol binds to cellular microtubulesQ36206521
Multidrug resistance: retrospect and prospects in anti-cancer drug treatment.Q36536479
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapyQ36558024
Toll-like receptors expressed in tumor cells: targets for therapyQ37078915
Role of TLR4 for paclitaxel chemotherapy in human epithelial ovarian cancer cellsQ39886489
Paclitaxel binding to human and murine MD-2.Q39957984
Transfection of Smac/DIABLO sensitizes drug-resistant tumor cells to TRAIL or paclitaxel-induced apoptosis in vitroQ40047160
TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistanceQ40165390
TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancerQ40296306
Toll-like receptors on tumor cells facilitate evasion of immune surveillanceQ40409088
Regulation of spontaneous and TNF/IFN-induced IL-6 expression in two human ovarian-carcinoma cell lines.Q40944786
Constitutive production of interleukin 6 by ovarian cancer cell lines and by primary ovarian tumor culturesQ41716249
The role of MyD88 and TLR4 in the LPS-mimetic activity of TaxolQ43704400
MyD88 is involved in the signalling pathway for Taxol-induced apoptosis and TNF-alpha expression in human myelomonocytic cellsQ44078286
The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascadesQ45059172
Stimulation of ovarian tumor cell proliferation with monocyte products including interleukin-1, interleukin-6, and tumor necrosis factor-αQ63446380
Shared actions of endotoxin and taxol on TNF receptors and TNF releaseQ68086156
Effects of interleukin-6 on in vitro cell attachment, migration and invasion of human ovarian carcinomaQ73147564
P53 mutation does not affect prognosis in ovarian epithelial malignanciesQ73820445
P433issue3
P921main subjecttoll-like receptorQ408004
paclitaxelQ423762
ovarian carcinomaQ18556145
P304page(s)871-877
P577publication date2013-12-16
P1433published inOncology LettersQ20640514
P1476titleTLR4 induces tumor growth and inhibits paclitaxel activity in MyD88-positive human ovarian carcinoma in vitro
P478volume7

Reverse relations

cites work (P2860)
Q64906922Chemotherapeutic Agent Paclitaxel Mediates Priming of NLRP3 Inflammasome Activation.
Q36609391Clinical and Emergent Biomarkers and Their Relationship to the Prognosis of Ovarian Cancer
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Q38737142Galectin-3 induces ovarian cancer cell survival and chemoresistance via TLR4 signaling activation
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Q41702685Inflammatory cytokine production in tumor cells upon chemotherapy drug exposure or upon selection for drug resistance
Q52595047MiR-216a exerts tumor-suppressing functions in renal cell carcinoma by targeting TLR4.
Q92823981NF-κB Signaling in Ovarian Cancer
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Q41897007Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer.
Q34501667Pretreatment of lipopolysaccharide (LPS) ameliorates D-GalN/LPS induced acute liver failure through TLR4 signaling pathway.
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Q35796070TLR4 has a TP53-dependent dual role in regulating breast cancer cell growth
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Q37269094Toll-like receptors 1, 2, 4 and 6 in esophageal epithelium, Barrett's esophagus, dysplasia and adenocarcinoma

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