Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1.

scientific article published on 29 January 2014

Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...984964D
P356DOI10.1371/JOURNAL.PONE.0084964
P932PMC publication ID3906007
P698PubMed publication ID24489654
P5875ResearchGate publication ID260062938

P50authorNicolas Sluis-CremerQ113121065
Michele D SobolewskiQ122973343
P2093author name stringJohn W Mellors
Deborah McMahon
Geneviève Doyon
Kelly Huber
P2860cites workIn vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency.Q52050894
Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line.Q53437454
The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4Q69518980
Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acidQ24596282
Suberoylanilide hydroxamic acid reactivates HIV from latently infected cellsQ24644201
ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremiaQ28469175
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infectionQ29619738
HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcriptionQ30835037
Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infectionQ33476165
Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell cloneQ33847737
Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapyQ34290545
Direct and quantitative single-cell analysis of human immunodeficiency virus type 1 reactivation from latencyQ34362915
Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activationQ35077057
Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridizationQ35589022
Effect of histone deacetylase inhibitors on HIV production in latently infected, resting CD4(+) T cells from infected individuals receiving effective antiretroviral therapyQ36379282
Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivationQ36409885
Integrated proviral human immunodeficiency virus type 1 is present in CD4+ peripheral blood lymphocytes in healthy seropositive individuals.Q36831526
New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasmaQ36891848
Phase II trial of bryostatin-1 in combination with cisplatin in patients with recurrent or persistent epithelial ovarian cancer: a California cancer consortium studyQ37115594
The challenge of finding a cure for HIV infectionQ37407598
Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategiesQ37644561
Structural basis for activation and inhibition of class I phosphoinositide 3-kinasesQ37947094
Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cellsQ42770444
Monokine regulation of human immunodeficiency virus-1 expression in a chronically infected human T cell cloneQ42813546
Prevalence and predictive value of intermittent viremia with combination hiv therapyQ43670221
Predictors of residual viremia in HIV-infected patients successfully treated with efavirenz and lamivudine plus either tenofovir or stavudineQ45300837
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)e84964
P577publication date2014-01-29
P1433published inPLOS OneQ564954
P1476titleDiscovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1.
P478volume9

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cites work (P2860)
Q35195281A high throughput RNAi screen reveals determinants of HIV-1 activity in host kinases
Q59359728CD4 T Cell Subsets and Pathways to HIV Latency
Q90683506Diversity of small molecule HIV-1 latency reversing agents identified in low- and high-throughput small molecule screens
Q33936233Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats.
Q26747110Glucose Metabolism in T Cells and Monocytes: New Perspectives in HIV Pathogenesis
Q56962083Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products
Q57050517Mesenchymal stem cells are attracted to latent HIV-1-infected cells and enable virus reactivation via a non-canonical PI3K-NFκB signaling pathway
Q92300043Strategies to eradicate HIV from infected patients: elimination of latent provirus reservoirs
Q37113972The role of Fc receptors in HIV prevention and therapy

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