CD4 T Cell Subsets and Pathways to HIV Latency

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CD4 T Cell Subsets and Pathways to HIV Latency is …
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P356DOI10.1089/AID.2018.0105
P932PMC publication ID6152855
P698PubMed publication ID29869531

P2093author name stringAndrew J Henderson
Luis M Agosto
P2860cites workHIV-1 cell to cell transfer across an Env-induced, actin-dependent synapseQ22242967
Avoiding the void: cell-to-cell spread of human virusesQ22251022
Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infectionQ22251080
BCL6 can repress transcription from the human immunodeficiency virus type I promoter/enhancer regionQ24318613
Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathwaysQ24323279
IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIVQ24567990
T cell recognition of weak ligands: roles of signaling, receptor number, and affinityQ24626152
T cell activationQ24658051
HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cellsQ24802813
Impact of Chromatin on HIV ReplicationQ26782046
Molecular mechanisms of T cell co-stimulation and co-inhibitionQ26864888
The immunological synapse: the gateway to the HIV reservoirQ27002959
Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosidesQ27318429
DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongationQ28139929
Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsQ28146072
Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanismQ28206139
HIV latencyQ37974218
Cell-to-cell transmission of virusesQ38065551
Mechanisms of enhanced HIV spread through T-cell virological synapsesQ38070789
T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironmentQ38072512
T cell receptor signalling networks: branched, diversified and boundedQ38092568
T cell antigen receptor activation and actin cytoskeleton remodelingQ38107331
An integrated overview of HIV-1 latencyQ38163449
The who's who of T-cell differentiation: human memory T-cell subsetsQ38164599
Atypical MHC class II-expressing antigen-presenting cells: can anything replace a dendritic cell?Q38260970
The role of human dendritic cells in HIV-1 infectionQ38269331
Analysis of interactions between huGATA-3 transcription factor and three GATA regulatory elements of HIV-1 long terminal repeat, by surface plasmon resonance.Q38341946
HIV cell-to-cell transmission: effects on pathogenesis and antiretroviral therapyQ38376002
BCL6 represses antiviral resistance in follicular T helper cellsQ38760711
Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infectionQ38812394
HIV integration site distributions in resting and activated CD4+ T cells infected in cultureQ38919402
Foxp3 inhibits HDAC1 activity to modulate gene expression in human T cellsQ38989129
Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1.Q39027865
The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4.Q39030295
T memory stem cells in health and disease.Q39070577
HIV Latency: Should We Shock or Lock?Q39078465
HIV latency and integration site placement in five cell-based models.Q39109122
Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcriptionQ37151045
Homeostasis of naive and memory T cellsQ37356053
Homeostatically Maintained Resting Naive CD4+ T Cells Resist Latent HIV Reactivation.Q37459228
Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA.Q37493334
Insights into the initiation of TCR signalingQ37580455
Suboptimal engagement of the T-cell receptor by a variety of peptide-MHC ligands triggers T-cell anergyQ37651126
Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 LatencyQ37695602
CD4+ memory stem cells are infected by HIV-1 in a manner regulated in part by SAMHD1 expressionQ37714035
Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamicsQ37737052
Signaling through the P38 and ERK pathways: a common link between HIV replication and the immune response.Q37781305
Understanding the structure and function of the immunological synapseQ37789101
Strength of TCR-peptide/MHC interactions and in vivo T cell responsesQ37866944
A human memory T cell subset with stem cell-like propertiesQ28248395
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiationQ28252247
Host-reactive CD8+ memory stem cells in graft-versus-host diseaseQ28281894
Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profileQ28508595
The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokinesQ28509281
Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHAQ28541244
Directly infected resting CD4+T cells can produce HIV Gag without spreading infection in a model of HIV latencyQ28728736
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cellsQ29614226
Central memory and effector memory T cell subsets: function, generation, and maintenanceQ29615097
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferationQ29619611
T cell exhaustionQ29620463
The accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent mannerQ30009437
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.Q30421200
Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentationQ30434547
Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cellsQ30483680
Human immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapseQ30491420
HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcriptionQ30835037
Homeostatic proliferation fails to efficiently reactivate HIV-1 latently infected central memory CD4+ T cellsQ31036545
HIV-1 pre-integration complexes selectively target decondensed chromatin in the nuclear peripheryQ33342802
Resting regulatory CD4 T cells: a site of HIV persistence in patients on long-term effective antiretroviral therapyQ33373073
Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activationQ33508788
Combinatorial signals from CD28 differentially regulate human immunodeficiency virus transcription in T cellsQ33549606
Negative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeatQ33602605
Both memory and CD45RA+/CD62L+ naive CD4(+) T cells are infected in human immunodeficiency virus type 1-infected individualsQ33816825
Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell cloneQ33847737
New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector functionQ33921903
HIV preferentially infects HIV-specific CD4+ T cellsQ33958893
Human immunodeficiency virus type 1 can establish latent infection in resting CD4+ T cells in the absence of activating stimuliQ34124009
A flexible model of HIV-1 latency permitting evaluation of many primary CD4 T-cell reservoirsQ34145909
Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissueQ34152017
Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton.Q34165677
Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individualsQ34218500
Induction of T cell anergy: integration of environmental cues and infectious toleranceQ34310174
Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infectionQ34420861
Nuclear architecture dictates HIV-1 integration site selection.Q34465264
Quantitation of replication-competent HIV-1 in populations of resting CD4+ T cellsQ34594969
Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169.Q34671896
HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cellsQ34672568
Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivoQ34717597
T cell anergyQ35019694
Myeloid dendritic cells induce HIV-1 latency in non-proliferating CD4+ T cellsQ35067224
Chromatin organization at the nuclear pore favours HIV replicationQ35196941
Molecular regulation of effector and memory T cell differentiationQ35283304
Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cellsQ35549754
FoxP3 enhances HIV-1 gene expression by modulating NFkappaB occupancy at the long terminal repeat in human T cellsQ35566145
Blimp-1, an intrinsic factor that represses HIV-1 proviral transcription in memory CD4+ T cells.Q35567041
Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cellsQ35785154
The role of antigen presenting cells in the induction of HIV-1 latency in resting CD4(+) T-cellsQ36053889
CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.Q36077348
The trinity of the cortical actin in the initiation of HIV-1 infectionQ36156531
Human T cells cannot act as autonomous antigen-presenting cells, but induce tolerance in antigen-specific and alloreactive responder cellsQ36231793
Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoirQ36318184
Endothelial cells augment T cell interleukin 2 production by a contact-dependent mechanism involving CD2/LFA-3 interactionQ36351065
Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approachQ36364264
Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cellsQ36365491
The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic modelQ36365507
The Strength of Persistent Antigenic Stimulation Modulates Adaptive Tolerance in Peripheral CD4+ T CellsQ36371739
The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulationQ36390497
Molecular regulation of T-cell anergyQ36466372
Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivoQ36607484
Selective targeting of ITK blocks multiple steps of HIV replication.Q36627588
Interleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organizationQ36687744
A Subset of CD4/CD8 Double-Negative T Cells Expresses HIV Proteins in Patients on Antiretroviral Therapy.Q36736780
Single-cell imaging of HIV-1 provirus (SCIP).Q36747516
The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.Q36804149
Interleukin-7 promotes HIV persistence during antiretroviral therapyQ36873277
FOXP3 inhibits HIV-1 infection of CD4 T-cells via inhibition of LTR transcriptional activityQ36990794
Induction of HIV-1 latency and reactivation in primary memory CD4+ T cellsQ37039142
Kinetics of CXCR4 and CCR5 up-regulation and human immunodeficiency virus expansion after antigenic stimulation of primary CD4(+) T lymphocytes.Q39205759
The Molecular Basis for Human Immunodeficiency Virus LatencyQ39439255
Characterization of chemokine receptor utilization of viruses in the latent reservoir for human immunodeficiency virus type 1.Q39592932
Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro.Q39645005
Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restrictionQ39712159
Human immunodeficiency virus integrates directly into naive resting CD4+ T cells but enters naive cells less efficiently than memory cellsQ39884805
PI4P5-kinase Ialpha is required for efficient HIV-1 entry and infection of T cellsQ39921900
HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.Q40051245
SMYD2-Mediated Histone Methylation Contributes to HIV-1 LatencyQ40205664
Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.Q40321547
Human T cell transcription factor GATA-3 stimulates HIV-1 expressionQ40407802
Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant RoleQ40665451
The protein tyrosine kinase Fyn activates transcription from the HIV promoter via activation of NF kappa B-like DNA-binding proteins.Q41275666
NF-kappa B-dependent and -independent pathways of HIV activation in a chronically infected T cell lineQ41452343
The Src kinase Lck facilitates assembly of HIV-1 at the plasma membraneQ41653444
A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection.Q42055809
Distinct gene-expression profiles associated with the susceptibility of pathogen-specific CD4 T cells to HIV-1 infection.Q42145907
CD28-dependent HIV-1 transcription is associated with Vav, Rac, and NF-kappa B activationQ42169398
Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells.Q42283389
Endothelial cell stimulation overcomes restriction and promotes productive and latent HIV-1 infection of resting CD4+ T cellsQ42286174
Host factor transcriptional regulation contributes to preferential expression of HIV type 1 in IL-4-producing CD4 T cellsQ42324067
Characterization of interactions between transcription factors and a regulatory region spanning nt -320 to -281 of the HIV-1 LTR in T-lymphoid and non-T-lymphoid cellsQ42516313
Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cellsQ42759901
Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutininQ42936502
ZAP-70 kinase regulates HIV cell-to-cell spread and virological synapse formation.Q42976627
CD28 ligation in the absence of TCR promotes RelA/NF-kappaB recruitment and trans-activation of the HIV-1 LTR.Q43463397
Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4+ T Cells Permissive for Latent HIV-1 InfectionQ44876281
HIV infection of primary human T cells is determined by tunable thresholds of T cell activationQ44910147
HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signalingQ45163196
Negative elongation factor NELF represses human immunodeficiency virus transcription by pausing the RNA polymerase II complexQ45405018
Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants.Q46281767
Recruitment of HIV and its receptors to dendritic cell-T cell junctionsQ47563778
Measuring integrated HIV DNA ex vivo and in vitro provides insights about how reservoirs are formed and maintainedQ49920984
CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency.Q51971372
Human effector memory CD4+ T cells directly recognize allogeneic endothelial cells in vitro and in vivo.Q51971439
A novel in vitro system to generate and study latently HIV-infected long-lived normal CD4+ T-lymphocytes.Q51980078
Memory T cells and their costimulators in human allograft injury.Q51988168
In patients on prolonged HAART, a significant pool of HIV infected CD4 T cells are HIV-specific.Q52010703
Nef enhances c-Cbl phosphorylation in HIV-infected CD4+ T lymphocytes.Q53622019
The pathway to establishing HIV latency is critical to how latency is maintained and reversed.Q54237426
Antigen presentation by T cells versus professional antigen-presenting cells (APC): differential consequences for T cell activation and subsequent T cell-APC interactionsQ61651913
Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-toleranceQ61783468
Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1Q72688559
DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infectionQ77589727
Transcriptional repressor Blimp-1 regulates T cell homeostasis and functionQ82974924
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectimmunologyQ101929
infectious diseaseQ18123741
P304page(s)780-789
P577publication date2018-09-01
P1433published inAIDS Research and Human RetrovirusesQ4651880
P1476titleCD4 T Cell Subsets and Pathways to HIV Latency
P478volume34

Reverse relations

cites work (P2860)
Q92697820Latency reversal agents affect differently the latent reservoir present in distinct CD4+ T subpopulations
Q64985976Mechanisms of HIV-1 cell-to-cell transmission and the establishment of the latent reservoir.
Q92216465Strength of T cell signaling regulates HIV-1 replication and establishment of latency

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