Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA

scientific article (publication date: March 2014)

Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PPAT.1003997
P3181OpenCitations bibliographic resource ID2915700
P932PMC publication ID3961356
P698PubMed publication ID24651404
P5875ResearchGate publication ID260997123

P50authorFrank MaldarelliQ90433858
Jason M BrenchleyQ114512804
Kuan-Teh JeangQ18235906
P2093author name stringVenkat S R K Yedavalli
Klaus Strebel
Paul Liu
Molly Perkins
Laurent Houzet
Zachary Klase
P2860cites workBioGPS: an extensible and customizable portal for querying and organizing gene annotation resourcesQ21183895
T-cell differentiation factor CBF-β regulates HIV-1 Vif-mediated evasion of host restrictionQ24300389
Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acidQ24596282
Suberoylanilide hydroxamic acid reactivates HIV from latently infected cellsQ24644201
Tat gets the "green" light on transcription initiationQ24815711
Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif proteinQ27860488
WebLogo: A Sequence Logo GeneratorQ27860646
The RUNX genes: gain or loss of function in cancerQ28247901
Inhibition of HIV replication in acute and chronic infections in vitro by a Tat antagonistQ28325213
The human immunodeficiency virus type 1 Tat antagonist, Ro 5-3335, predominantly inhibits transcription initiation from the viral promoterQ28368856
PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesisQ32884406
The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregatesQ33781796
Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cellsQ33787937
Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1.Q34161703
Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infectionQ34242229
Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapyQ34290545
Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interactionQ34388355
The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuitQ34544409
Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapyQ34714816
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro.Q34985945
RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulationQ35005536
Structure and regulated expression of mammalian RUNX genesQ35779684
Role of RUNX family members in transcriptional repression and gene silencingQ35779689
Epigenetic gene silencing by Runx proteinsQ35779768
HIV-1 Vif promotes the G₁- to S-phase cell-cycle transitionQ35874198
Phosphorylation, acetylation and ubiquitination: the molecular basis of RUNX regulationQ36329898
Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivationQ36409885
trans activation of human immunodeficiency virus type 1 is sequence specific for both the single-stranded bulge and loop of the trans-acting-responsive hairpin: a quantitative analysis.Q36832567
Discovery of selective, small-molecule inhibitors of RNA complexes--I. The Tat protein/TAR RNA complexes required for HIV-1 transcriptionQ36870972
RUNX proteins in transcription factor networks that regulate T-cell lineage choiceQ37376016
Runx and ThPOK: a balancing act to regulate thymocyte lineage commitmentQ37500268
Mutation of all Runx (AML1/core) sites in the enhancer of T-lymphomagenic SL3-3 murine leukemia virus unmasks a significant potential for myeloid leukemia induction and favors enhancer evolution toward induction of other disease patternsQ37596450
Mechanisms of HIV latency: an emerging picture of complexityQ37738147
Regulation of gene expression in peripheral T cells by Runx transcription factorsQ37748069
Interplay of transcription factors in T-cell differentiation and function: the role of RunxQ37811064
Epigenetic regulation of HIV latencyQ37829626
HDAC inhibitors in HIV.Q37956178
Short communication: activation of latent HIV type 1 gene expression by suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor approved for use to treat cutaneous T cell lymphomaQ39262129
TEThered to Runx: novel binding partners for runx factorsQ39719445
Molecular basis for a dominant inactivation of RUNX1/AML1 by the leukemogenic inversion 16 chimeraQ40568990
A randomized trial of the activity and safety of Ro 24-7429 (Tat antagonist) versus nucleoside for human immunodeficiency virus infection. The AIDS Clinical Trials Group 213 TeamQ42276768
HIV type 1 viral infectivity factor and the RUNX transcription factors interact with core binding factor β on genetically distinct surfaces.Q42348425
Down-regulation of Runx1 expression by TCR signal involves an autoregulatory mechanism and contributes to IL-2 production.Q42703663
Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages.Q43183907
CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression.Q43239447
Using TESS to predict transcription factor binding sites in DNA sequenceQ44375395
Tat trans-activates the human immunodeficiency virus through a nascent RNA targetQ45847022
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.Q52111650
Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice.Q54631830
HIV replication in chronically infected macrophages is not inhibited by the Tat inhibitors Ro-5-3335 and Ro-24-7429Q72182513
Functional redundancy of transcription factor-binding sites in the killer cell Ig-like receptor (KIR) gene promoterQ79833910
Perspectives on RUNX genes: an updateQ84730573
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectro-5-3335Q27887134
P304page(s)e1003997
P577publication date2014-03-01
P1433published inPLOS PathogensQ283209
P1476titleActivation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA
P478volume10

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