Identification of type II inhibitors targeting BRAF using privileged pharmacophores

scientific article published on 25 October 2013

Identification of type II inhibitors targeting BRAF using privileged pharmacophores is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/CBDD.12198
P698PubMed publication ID24164966
P5875ResearchGate publication ID258115250

P2093author name stringFei Wang
Juan Wang
Qingwen Zhang
Qidong You
Xiuhua Chen
Houyuan Zhou
Yunsong He
P2860cites workClinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanomaQ24597152
Mutations of the BRAF gene in human cancerQ27860760
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAFQ28251989
Guilty as charged: B-RAF is a human oncogeneQ28288202
Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumorsQ28297412
Patterns of somatic mutation in human cancer genomesQ29547841
Rational design of inhibitors that bind to inactive kinase conformationsQ29617558
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesisQ29617585
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancerQ29618155
Chemical inhibitors of protein kinasesQ34466054
Molecular recognition of protein kinase binding pockets for design of potent and selective kinase inhibitorsQ36723753
Small molecule inhibitors of BRAF in clinical trialsQ37973551
Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors.Q39779613
Pyridoimidazolones as novel potent inhibitors of v-Raf murine sarcoma viral oncogene homologue B1 (BRAF).Q39867959
Urea derivatives of STI571 as inhibitors of Bcr-Abl and PDGFR kinasesQ40500728
Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activityQ42775676
The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: a structural analysis of the binding interactions of Gleevec, Nexavar, and BIRB-796.Q42973748
P433issue1
P304page(s)27-36
P577publication date2013-10-25
P1433published inChemical Biology and Drug DesignQ15749458
P1476titleIdentification of type II inhibitors targeting BRAF using privileged pharmacophores
P478volume83