Fosfomycin: Mechanism and Resistance

scientific article published on 6 January 2017

Fosfomycin: Mechanism and Resistance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/CSHPERSPECT.A025262
P932PMC publication ID5287057
P698PubMed publication ID28062557

P2093author name stringLynn L Silver
P2860cites workFrequency of spontaneous resistance to fosfomycin combined with different antibiotics in Pseudomonas aeruginosaQ42375984
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Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.Q54590227
Fosfomycin-resistant mutant of Escherichia coliQ54637966
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Phosphonomycin. IV. Susceptibility testing method and surveyQ71363334
Detection and characterization of a phospholactoyl-enzyme adduct in the reaction catalyzed by UDP-N-acetylglucosamine enolpyruvoyl transferase, MurZQ72160243
Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolpyruvoyl transferase by the antibiotic fosfomycinQ72160246
Phosphonomycin, a New Antibiotic Produced by Strains of StreptomycesQ72475705
Evidence that the reaction of the UDP-N-acetylglucosamine 1-carboxyvinyltransferase proceeds through the O-phosphothioketal of pyruvic acid bound to Cys115 of the enzymeQ72709263
Fosfadecin and fosfocytocin, new nucleotide antibiotics produced by bacteria.Q78420692
Fosfomycin Monophosphate and Fosfomycin Diphosphate, Two Inactivated Fosfomycin Derivatives Formed by Gene Products of fomA and fomB from a Fosfomycin Producing Organism Streptomyces wedmorensis.Q78422728
The ECO*SENS Project: a prospective, multinational, multicentre epidemiological survey of the prevalence and antimicrobial susceptibility of urinary tract pathogens-interim reportQ95799925
Essential Bacillus subtilis genesQ24681292
Molecular Mechanisms and Clinical Impact of Acquired and Intrinsic Fosfomycin ResistanceQ26853135
Resistance to antibiotics targeted to the bacterial cell wallQ26859841
Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA)Q27677546
Structure and Function of the Genomically Encoded Fosfomycin Resistance Enzyme, FosB, from Staphylococcus aureusQ27681408
Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycinQ27734363
MurAA, catalysing the first committed step in peptidoglycan biosynthesis, is a target of Clp-dependent proteolysis in Bacillus subtilisQ28488903
The glycerol-3-phosphate permease GlpT is the only fosfomycin transporter in Pseudomonas aeruginosaQ28492495
Antimicrobial Susceptibility and Molecular Mechanisms of Fosfomycin Resistance in Clinical Escherichia coli Isolates in Mainland ChinaQ28547100
Distribution of an Inducible Hexose-Phosphate Transport System Among Various BacteriaQ30451434
Fosfomycin for the treatment of infections caused by multidrug-resistant non-fermenting Gram-negative bacilli: a systematic review of microbiological, animal and clinical studiesQ33436519
In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistinQ33558996
Assessing the emergence of resistance: the absence of biological cost in vivo may compromise fosfomycin treatments for P. aeruginosa infectionsQ33564290
Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteriaQ33601835
Fosfomycin for the treatment of multidrug-resistant, including extended-spectrum beta-lactamase producing, Enterobacteriaceae infections: a systematic review.Q34096605
The mechanism of action of fosfomycin (phosphonomycin)Q34214482
Fosfomycin: use beyond urinary tract and gastrointestinal infectionsQ34774778
Biological costs and mechanisms of fosfomycin resistance in Escherichia coliQ35685710
Glycerol-3-phosphate transporter of Escherichia coli: structure, function and regulationQ35893671
Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: MurA confers clinical resistance at low fitness costQ35941216
Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species.Q36171710
The discovery of cell wall active antibacterial antibioticsQ36335002
Transport of antibiotics and metabolite analogs by systems under cyclic AMP control: positive selection of Salmonella typhimurium cya and crp mutantsQ36417093
FosfomycinQ36675246
Comparison of the essential cellular functions of the two murA genes of Bacillus anthracisQ36702923
Plasmid-encoded fosfomycin resistanceQ37187074
Fosfomycin versus other antibiotics for the treatment of cystitis: a meta-analysis of randomized controlled trialsQ37768581
Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product releaseQ37866109
Fosfomycin: evaluation of the published evidence on the emergence of antimicrobial resistance in Gram-negative pathogens.Q37957839
Two kinds of mutants defective in multiple carbohydrate utilization isolated from in vitro fosfomycin-resistant strains of Escherichia coli K-12Q40145885
Clinically relevant concentrations of fosfomycin combined with polymyxin B, tobramycin or ciprofloxacin enhance bacterial killing of Pseudomonas aeruginosa, but do not suppress the emergence of fosfomycin resistance.Q40697349
In vitro pharmacodynamics of fosfomycin against clinical isolates of Pseudomonas aeruginosa.Q40698278
Exploration of the Pharmacokinetic-Pharmacodynamic Relationships for Fosfomycin Efficacy Using an In Vitro Infection ModelQ40810228
Dissemination of a clone carrying a fosA3-harbouring plasmid mediates high fosfomycin resistance rate of KPC-producing Klebsiella pneumoniae in ChinaQ41633267
Cell-wall-inhibiting antibiotic combinations with activity against multidrug-resistant Klebsiella pneumoniae and Escherichia coli.Q42244641
P433issue2
P577publication date2017-01-06
P1433published inCold Spring Harbor Perspectives in MedicineQ21042440
P1476titleFosfomycin: Mechanism and Resistance
P478volume7

Reverse relations

cites work (P2860)
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Q40075723Widespread Fosfomycin Resistance in Gram-Negative Bacteria Attributable to the Chromosomal fosA Gene

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