Molecular Mechanisms and Clinical Impact of Acquired and Intrinsic Fosfomycin Resistance

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Molecular Mechanisms and Clinical Impact of Acquired and Intrinsic Fosfomycin Resistance is …
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P356DOI10.3390/ANTIBIOTICS2020217
P932PMC publication ID4790336
P698PubMed publication ID27029300

P50authorJesus BlazquezQ68273789
P2093author name stringAlexandro Rodríguez-Rojas
Alfredo Castañeda-García
P2860cites workBiosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in BacilliQ24599939
MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coliQ24671787
Product of fosC, a gene from Pseudomonas syringae, mediates fosfomycin resistance by using ATP as cosubstrateQ24676974
Crystal structure of a genomically encoded fosfomycin resistance protein (FosA) at 1.19 A resolution by MAD phasing off the L-III edge of Tl(+)Q27639636
Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coliQ27641769
Mechanistic diversity of fosfomycin resistance in pathogenic microorganismsQ27642794
Structure and mechanism of the genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenesQ27645727
Crystal Structure of Fosfomycin Resistance Kinase FomA from Streptomyces wedmorensisQ27651553
Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycinQ27734363
FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilisQ28359895
Identification of Bacillus subtilis sigma-dependent genes that provide intrinsic resistance to antimicrobial compounds produced by BacilliQ28489040
The glycerol-3-phosphate permease GlpT is the only fosfomycin transporter in Pseudomonas aeruginosaQ28492495
Regulation of glycerol metabolism in Pseudomonas aeruginosa: characterization of the glpR repressor geneQ28492997
Separate contributions of UhpA and CAP to activation of transcription of the uhpT promoter of Escherichia coliQ30304322
UhpT, the sugar phosphate antiporter of Escherichia coli, functions as a monomer.Q54710974
The mechanism of glucose 6-phosphate transport by Escherichia coli.Q54748501
Detection and characterization of a phospholactoyl-enzyme adduct in the reaction catalyzed by UDP-N-acetylglucosamine enolpyruvoyl transferase, MurZQ72160243
Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolpyruvoyl transferase by the antibiotic fosfomycinQ72160246
Antibacterial spectrum of fosfomycin trometamolQ72282822
Phosphonomycin, a New Antibiotic Produced by Strains of StreptomycesQ72475705
Evidence that the reaction of the UDP-N-acetylglucosamine 1-carboxyvinyltransferase proceeds through the O-phosphothioketal of pyruvic acid bound to Cys115 of the enzymeQ72709263
Two different types of fosfomycin resistance in clinical isolates of Klebsiella pneumoniaeQ72738096
Fosfomycin Monophosphate and Fosfomycin Diphosphate, Two Inactivated Fosfomycin Derivatives Formed by Gene Products of fomA and fomB from a Fosfomycin Producing Organism Streptomyces wedmorensis.Q78422728
Antibiotics at the crossroadsQ80889994
Coexpression of virulence and fosfomycin susceptibility in Listeria: molecular basis of an antimicrobial in vitro-in vivo paradoxQ83190850
Plasmid-mediated fosfomycin resistance in Escherichia coli isolated from pig.Q52301661
Elucidation of a monovalent cation dependence and characterization of the divalent cation binding site of the fosfomycin resistance protein (FosA).Q54093237
Mechanistic imperatives for the evolution of glutathione transferases.Q54116649
Dissemination of plasmid-mediated fosfomycin resistance fosA3 among multidrug-resistant Escherichia coli from livestock and other animals.Q54321678
Fosfomycin monophosphate and fosfomycin diphosphate, two inactivated fosfomycin derivatives formed by gene products of fomA and fomB from a fosfomycin producing organism Streptomyces wedmorensis.Q54589592
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.Q54590227
Characterization of spontaneous fosfomycin (phosphonomycin)-resistant cells of Escherichia coli B in vitroQ54621230
Detection of the covalent intermediate of UDP-N-acetylglucosamine enolpyruvyl transferase by solution-state and time-resolved solid-state NMR spectroscopy.Q54622132
Effect of altered spacing between uhpT promoter elements on transcription activationQ30305885
Mutational scanning and affinity cleavage analysis of UhpA-binding sites in the Escherichia coli uhpT promoterQ30309257
Isolation and characterization of mutations affecting the transport of hexose phosphates in Escherichia coliQ30451453
Interplay between the membrane-associated UhpB and UhpC regulatory proteinsQ30451823
Topology of the Escherichia coli uhpT sugar-phosphate transporter analyzed by using TnphoA fusionsQ30451878
Genetic control of the hexose phosphate transport system of Escherichia coli: mapping of deletion and insertion mutations in the uhp regionQ30451961
Transcription activation at the Escherichia coli uhpT promoter by the catabolite gene activator proteinQ30452528
Protein phosphorylation affects binding of the Escherichia coli transcription activator UhpA to the uhpT promoterQ30469920
Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferaseQ33202551
Fosfomycin for the treatment of infections caused by multidrug-resistant non-fermenting Gram-negative bacilli: a systematic review of microbiological, animal and clinical studiesQ33436519
Assessing the emergence of resistance: the absence of biological cost in vivo may compromise fosfomycin treatments for P. aeruginosa infectionsQ33564290
Hpt, a bacterial homolog of the microsomal glucose- 6-phosphate translocase, mediates rapid intracellular proliferation in ListeriaQ33898004
Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymesQ33962732
Uncomplicated urinary tract infectionsQ33966916
Emergence of fosfomycin-resistant isolates of Shiga-like toxin-producing Escherichia coli O26Q33976610
Mechanistic diversity in a metalloenzyme superfamilyQ34081644
Fosfomycin for the treatment of multidrug-resistant, including extended-spectrum beta-lactamase producing, Enterobacteriaceae infections: a systematic review.Q34096605
Characterization of the N-acetyl-α-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis .Q34145984
Interaction of fosfomycin with the glycerol 3-phosphate transporter of Escherichia coliQ34203685
The mechanism of action of fosfomycin (phosphonomycin)Q34214482
Mechanistic studies of FosB: a divalent-metal-dependent bacillithiol-S-transferase that mediates fosfomycin resistance in Staphylococcus aureusQ34318798
Fosfomycin resistance proteins: a nexus of glutathione transferases and epoxide hydrolases in a metalloenzyme superfamilyQ34482492
In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistanceQ34514901
Fosfomycin: use beyond urinary tract and gastrointestinal infectionsQ34774778
Potential of old-generation antibiotics to address current need for new antibioticsQ34850409
Antimicrobial susceptibilities of commonly encountered bacterial isolates to fosfomycin determined by agar dilution and disk diffusion methodsQ35191584
Why fosfomycin trometamol as first line therapy for uncomplicated UTI?Q35550901
Repressor for the sn-glycerol 3-phosphate regulon of Escherichia coli K-12: primary structure and identification of the DNA-binding domainQ35617874
Biological costs and mechanisms of fosfomycin resistance in Escherichia coliQ35685710
The structural basis of substrate translocation by the Escherichia coli glycerol-3-phosphate transporter: a member of the major facilitator superfamily.Q35863883
Dissemination of the fosfomycin resistance gene fosA3 with CTX-M β-lactamase genes and rmtB carried on IncFII plasmids among Escherichia coli isolates from pets in ChinaQ35867426
Glycerol-3-phosphate transporter of Escherichia coli: structure, function and regulationQ35893671
Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: MurA confers clinical resistance at low fitness costQ35941216
Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species.Q36171710
Pi exchange mediated by the GlpT-dependent sn-glycerol-3-phosphate transport system in Escherichia coliQ36292066
Experience with fosfomycin for treatment of urinary tract infections due to multidrug-resistant organismsQ36364199
Transport of antibiotics and metabolite analogs by systems under cyclic AMP control: positive selection of Salmonella typhimurium cya and crp mutantsQ36417093
Fosfomycin resistance: selection method for internal and extended deletions of the phosphoenolpyruvate:sugar phosphotransferase genes of Salmonella typhimuriumQ36576297
Isolation and Characterization of a Phosphonomycin-Resistant Mutant of Escherichia coli K-12Q36776831
Fosfomycin resistance protein (FosA) is a manganese metalloglutathione transferase related to glyoxalase I and the extradiol dioxygenasesQ36855782
Has the era of untreatable infections arrived?Q37578902
Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product releaseQ37866109
Interaction at a distance between multiple operators controls the adjacent, divergently transcribed glpTQ-glpACB operons of Escherichia coli K-12Q38329869
Characterization of the fomA and fomB gene products from Streptomyces wedmorensis, which confer fosfomycin resistance on Escherichia coli.Q39473127
Purification of a glutathione S-transferase that mediates fosfomycin resistance in bacteriaQ39815931
Formation of an adduct between fosfomycin and glutathione: a new mechanism of antibiotic resistance in bacteriaQ39832506
Plasmid-mediated fosfomycin resistance is due to enzymatic modification of the antibioticQ39834189
Tn292l, a transposon encoding fosfomycin resistanceQ39984364
Mapping of a genetic locus that affects glycerol 3-phosphate transport in Bacillus subtilisQ39989775
Two kinds of mutants defective in multiple carbohydrate utilization isolated from in vitro fosfomycin-resistant strains of Escherichia coli K-12Q40145885
Plasmid-determined resistance to fosfomycin in Serratia marcescensQ40282582
In vitro investigations with fosfomycin on mueller-hinton agar with and without glucose-6-phosphateQ41132405
The Action of Fosfomycin on the Growth of <i>Pseudomonas aeruginosa</i>Q41223336
Evolution of the antibiotic resistance protein, FosA, is linked to a catalytically promiscuous progenitorQ41909814
Nucleotide sequence of the fosB gene conferring fosfomycin resistance in Staphylococcus epidermidisQ42636633
Novel Fosfomycin resistance of Pseudomonas aeruginosa clinical isolates recovered in Japan in 1996.Q42729873
Complete nucleotide sequence of the fosfomycin resistance transposon Tn2921.Q43170822
Molecular mechanisms of fosfomycin resistance in clinical isolates of Escherichia coliQ43195414
CTX-M-15-producing urinary Escherichia coli O25b-ST131-phylogroup B2 has acquired resistance to fosfomycin.Q43293884
Fosfomycin-resistance plasmids determine an intracellular modification of fosfomycinQ43423840
Elementary steps in the acquisition of Mn2+ by the fosfomycin resistance protein (FosA).Q43767464
Characterization of staphylococcal plasmids hybridizing with the fosfomycin resistance gene fosBQ44598953
Fosmidomycin Resistance in Adenylate Cyclase Deficient (cya) Mutants ofEscherichia coliQ44603208
Pseudomonas aeruginosa fosfomycin resistance mechanisms affect non-inherited fluoroquinolone toleranceQ44676765
Prevalence of acquired fosfomycin resistance among extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae clinical isolates in Korea and IS26-composite transposon surrounding fosA3.Q44686193
Purification and characterization of the repressor for the sn-glycerol 3-phosphate regulon of Escherichia coli K12.Q45077702
Action at a distance for glp repressor control of glpTQ transcription in Escherichia coli K-12.Q45105122
Functional analysis of active site residues of the fosfomycin resistance enzyme FosA from Pseudomonas aeruginosaQ45291346
Complete nucleotide sequence of pKP96, a 67 850 bp multiresistance plasmid encoding qnrA1, aac(6')-Ib-cr and blaCTX-M-24 from Klebsiella pneumoniaeQ46313718
Alteration of a single amino acid residue reverses fosfomycin resistance of recombinant MurA from Mycobacterium tuberculosisQ47904411
Plasmid-encoded fosfomycin resistance in bacteria isolated from the urinary tract in a multicentre surveyQ48044137
Complete nucleotide sequence of pHN7A8, an F33:A-:B- type epidemic plasmid carrying blaCTX-M-65, fosA3 and rmtB from ChinaQ48046208
Lyme disease enolpyruvyl-UDP-GlcNAc synthase: fosfomycin-resistant MurA from Borrelia burgdorferi, a fosfomycin-sensitive mutant, and the catalytic role of the active site Asp.Q48060200
Nucleotide sequence and transcriptional startpoint of the glpT gene of Escherichia coli: extensive sequence homology of the glycerol-3-phosphate transport protein with components of the hexose-6-phosphate transport systemQ48335994
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)217-236
P577publication date2013-04-16
P1433published inAntibiotics (Basel, Switzerland)Q27725829
P1476titleMolecular Mechanisms and Clinical Impact of Acquired and Intrinsic Fosfomycin Resistance
P478volume2

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