WNT/β-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production

scientific article published on October 2013

WNT/β-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/HMG/DDT484
P698PubMed publication ID24087794
P5875ResearchGate publication ID257303032

P50authorGuillaume AssiéQ56704824
Bruno RagazzonQ37841591
Jérôme BertheratQ40382686
Anne-Marie Lefrançois-MartinezQ40384765
Isabelle Sahut-BarnolaQ40384859
Marie Batisse-LignierQ40386181
Sheerazed BoulkrounQ41564222
Maria-Christina ZennaroQ41564225
Laurence AmarQ42862168
P2093author name stringAntoine Martinez
Pierre Val
Annabel Berthon
Coralie Drelon
Frédérique Tissier
Michelina Plateroti
Pierre-François Plouin
Seham Skah
Benoît Samson-Couterie
Hervé Lefèbvre
P2860cites workNuclear hormone receptor NR4A2 is involved in cell transformation and apoptosisQ46727309
Efficacy and tolerance of spironolactone in essential hypertension.Q51628320
Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex.Q51953100
The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis.Q53353779
The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.Q53389774
Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism.Q54327400
Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressive adrenocortical cancers.Q54405863
Aldosterone-Producing Adenoma Formation in the Adrenal Cortex Involves Expression of Stem/Progenitor Cell MarkersQ57817519
Adenovirus-delivered DKK3/WNT4 and steroidogenesis in primary cultures of adrenocortical cellsQ24303644
Analysis of the role of Igf2 in adrenal tumour development in transgenic mouse modelsQ27321080
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancerQ28251800
Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivoQ28472494
Disabled-2 is expressed in adrenal zona glomerulosa and is involved in aldosterone secretionQ28583762
Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone productionQ28585089
Apc tumor suppressor gene is the "zonation-keeper" of mouse liverQ28589915
TASK channel deletion in mice causes primary hyperaldosteronismQ30441139
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complexQ31038919
Conditional deletion of beta-catenin mediated by Amhr2cre in mice causes female infertilityQ33583651
Aldosterone-producing adenoma and other surgically correctable forms of primary aldosteronismQ33930728
WNT4 is required for normal ovarian follicle development and female fertility.Q34017075
miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop.Q34055717
The flavonoid quercetin in disease prevention and therapy: facts and fanciesQ34209493
Identifying microRNA-mRNA regulatory network in colorectal cancer by a combination of expression profile and bioinformatics analysis.Q34306416
Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertensionQ34328209
Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growthQ34334258
Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filterQ34359244
Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells.Q34421814
Protocol for the fast chromatin immunoprecipitation (ChIP) methodQ34615353
Follicle-stimulating hormone/cAMP regulation of aromatase gene expression requires beta-cateninQ34945269
Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD).Q35110734
Changes in the perceived epidemiology of primary hyperaldosteronismQ35151575
Convergence of 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A and glycogen synthase kinase-3beta/beta-catenin signaling in corpus luteum progesterone synthesisQ35543017
Inhibition of β-catenin signaling by nongenomic action of orphan nuclear receptor Nur77Q35670308
Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanismsQ35684610
K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertensionQ36019674
Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells.Q36134732
The potassium channel, Kir3.4 participates in angiotensin II-stimulated aldosterone production by a human adrenocortical cell lineQ36177385
Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasisQ36391968
MEF2A regulates the Gtl2-Dio3 microRNA mega-cluster to modulate WNT signaling in skeletal muscle regenerationQ36444120
miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cellsQ36451980
Frequent epigenetic inactivation of Wnt antagonist genes in breast cancerQ36510089
Mitogenic Effect of Orphan Receptor TR3 and Its Regulation by MEKK1 in Lung Cancer CellsQ37061820
Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and diseaseQ37102953
Brachy-syndactyly caused by loss of Sfrp2 functionQ37180939
WNT signaling in ovarian follicle biology and tumorigenesisQ37624186
Targeting Wnt signaling: can we safely eradicate cancer stem cells?Q37763415
Wnt/β-catenin signalling in adrenal physiology and tumour developmentQ37935239
Outcomes of adrenalectomy in patients with unilateral primary aldosteronism: a reviewQ37991222
Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumorsQ37996386
Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo- and active-controlled phase 2 trialQ38483164
Cross-talk between NR4A orphan nuclear receptors and β-catenin signaling pathway in osteoblastsQ39583898
Lack of beneficial metabolic effects of quercetin in adult spontaneously hypertensive rats.Q39776704
Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathwayQ39851799
Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancerQ40171588
Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signalingQ40690911
The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone productionQ42453510
Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronismQ42908792
Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development.Q43182598
Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6.Q43214302
Trends in the prevalence of primary aldosteronism, aldosterone-producing adenomas, and surgically correctable aldosterone-dependent hypertensionQ44805596
P433issue4
P304page(s)889-905
P577publication date2013-10-01
P1433published inHuman Molecular GeneticsQ2720965
P1476titleWNT/β-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production
P478volume23

Reverse relations

cites work (P2860)
Q46722939ARMC5 mutation analysis in patients with primary aldosteronism and bilateral adrenal lesions.
Q48165772ARMC5 mutations in familial and sporadic primary bilateral macronodular adrenal hyperplasia.
Q36506804Activating mutations in CTNNB1 in aldosterone producing adenomas
Q26852504Adrenocortical zonation, renewal, and remodeling
Q92135237Altered expression of renin-angiotensin system receptors throughout colorectal adenoma-adenocarcinoma sequence
Q42366425CTNNB1 Mutation in Aldosterone Producing Adenoma.
Q39035325Cell signaling pathways in the adrenal cortex: Links to stem/progenitor biology and neoplasia
Q50079172Cilostazol Mediated Nurr1 and Autophagy Enhancement: Neuroprotective Activity in Rat Rotenone PD Model
Q38271545Clinicopathological correlates of adrenal Cushing's syndrome.
Q55129846Comparative Genomics and Transcriptome Profiling in Primary Aldosteronism.
Q35288453DACH1, a zona glomerulosa selective gene in the human adrenal, activates transforming growth factor-β signaling and suppresses aldosterone secretion
Q35800278Development of adrenal cortex zonation
Q26770421ENDOCRINE TUMOURS: The genomics of adrenocortical tumors
Q39791179EZH2 is overexpressed in adrenocortical carcinoma and is associated with disease progression
Q34520848Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction
Q90480926Frequency of somatic mutations in TERT promoter, TP53 and CTNNB1 genes in patients with hepatocellular carcinoma from Southern Italy
Q52739004Functional Implications of LH/hCG Receptors in Pregnancy-Induced Cushing Syndrome.
Q38793396Genetics of adrenocortical tumours
Q26799128Genetics of primary bilateral macronodular adrenal hyperplasia: a model for early diagnosis of Cushing's syndrome?
Q36993109Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma.
Q36619098Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis.
Q35680832LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal
Q89026053MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation
Q98386954Molecular Basis of Primary Aldosteronism and Adrenal Cushing Syndrome
Q36716084Molecular Heterogeneity in Aldosterone-Producing Adenomas
Q35726125Molecular and Cellular Mechanisms of Aldosterone Producing Adenoma Development
Q99631170Molecular mechanisms of ARMC5 mutations in adrenal pathophysiology
Q26740687Mouse Models Recapitulating Human Adrenocortical Tumors: What Is Lacking?
Q36803630Nurr1-Based Therapies for Parkinson's Disease.
Q39013180Of channels and pumps: different ways to boost the aldosterone?
Q37263731PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
Q49788223PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal
Q98158788Pathogenesis and treatment of primary aldosteronism
Q30248429Primary Aldosteronism: Changing Definitions and New Concepts of Physiology and Pathophysiology Both Inside and Outside the Kidney
Q45567424Primary aldosteronism patients show skin alterations and abnormal activation of glucocorticoid receptor in keratinocytes.
Q36288064Regulation of the adrenocortical stem cell niche: implications for disease
Q38952304Regulation of zonation and homeostasis in the adrenal cortex.
Q90663453Retinoic acid receptor α as a novel contributor to adrenal cortex structure and function through interactions with Wnt and Vegfa signalling
Q51783800Review of Markers of Zona Glomerulosa and Aldosterone-Producing Adenoma Cells.
Q64888338Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex.
Q90209698The Biology of Normal Zona Glomerulosa and Aldosterone-Producing Adenoma: Pathological Implications
Q54981564The Many Faces of Primary Aldosteronism and Cushing Syndrome: A Reflection of Adrenocortical Tumor Heterogeneity.
Q37051740The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3.
Q37593326The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes
Q90540475Timeline of Advances in Genetics of Primary Aldosteronism
Q37401418Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues
Q57822882Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma
Q34850075Understanding primary aldosteronism: impact of next generation sequencing and expression profiling.
Q34131672Wnt signaling inhibits adrenal steroidogenesis by cell-autonomous and non-cell-autonomous mechanisms

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