PI3K signaling mediates diverse regulation of ATF4 expression for the survival of HK-2 cells exposed to cadmium

scientific article published on 22 September 2013

PI3K signaling mediates diverse regulation of ATF4 expression for the survival of HK-2 cells exposed to cadmium is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00204-013-1129-Y
P698PubMed publication ID24057571

P2093author name stringKota Fujiki
Masato Matsuoka
Hisako Inamura
P2860cites workEffects of salubrinal on cadmium-induced apoptosis in HK-2 human renal proximal tubular cellsQ42728432
Involvement of both intrinsic and extrinsic pathways in hepatoprotection of arjunolic acid against cadmium induced acute damage in vitroQ42745532
Activation of RSK by UV-light: phosphorylation dynamics and involvement of the MAPK pathway.Q42797539
Glycogen synthase kinase-3 is the predominant insulin-regulated eukaryotic initiation factor 2B kinase in skeletal muscle.Q52569751
FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive ConditionsQ57371808
The RSK family of kinases: emerging roles in cellular signallingQ24315679
Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphonyQ24629514
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase BQ27860731
90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.Q27863657
Phosphatidic acid-mediated mitogenic activation of mTOR signalingQ28208274
Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulinQ28262178
Cadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3β/β-catenin signalingQ28389261
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell deathQ28577801
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase BalphaQ28616168
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
Intracellular signalling: PDK1--a kinase at the hub of thingsQ33533793
Activating transcription factor 4 regulates osteoclast differentiation in mice.Q34028709
Cadmium induces the expression of Grp78, an endoplasmic reticulum molecular chaperone, in LLC-PK1 renal epithelial cellsQ34687452
Apoptosis induced by cadmiumQ35596810
Cadmium increases HIF-1 and VEGF expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cellsQ35626776
ER stress and the unfolded protein responseQ35986601
Stimulation of phosphoinositide 3-kinase/Akt signaling by copper and zinc ions: mechanisms and consequences.Q36825323
Pleiotropic effects of cadmium in mesangial cells.Q37398178
Endoplasmic reticulum stress as a progression factor for kidney injuryQ37666123
Akt signalling in health and disease.Q37881228
Regulation and function of the RSK family of protein kinasesQ37970380
Roles of EGFR, PI3K, AKT, and mTOR in heavy metal-induced cancerQ38072460
Upregulation of amino acid transporter expression induced by L-leucine availability in L6 myotubes is associated with ATF4 signaling through mTORC1-dependent mechanismQ39277005
Transforming growth factor β suppresses osteoblast differentiation via the vimentin activating transcription factor 4 (ATF4) axisQ39284764
Insulin modulates induction of glucose‐regulated protein 78 during endoplasmic reticulum stress via augmentation of ATF4 expression in human neuroblastoma cellsQ39674481
Induction of mitogenic signalling in the 1LN prostate cell line on exposure to submicromolar concentrations of cadmium+Q40633539
TGFβ enforces activation of eukaryotic elongation factor‐2 (eEF2) via inactivation of eEF2 kinase by p90 ribosomal S6 kinase (p90Rsk) to induce mesangial cell hypertrophyQ41974987
Cadmium-induced expression of immediate early genes in LLC-PK1 cellsQ42276203
P433issue2
P304page(s)403-414
P577publication date2013-09-22
P1433published inArchives of ToxicologyQ635837
P1476titlePI3K signaling mediates diverse regulation of ATF4 expression for the survival of HK-2 cells exposed to cadmium
P478volume88

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cites work (P2860)
Q42702192Ameliorative Effects of Selenium on Cadmium-Induced Oxidative Stress and Endoplasmic Reticulum Stress in the Chicken Kidney
Q38966521Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells
Q37482851Endoplasmic reticulum stress eIF2α-ATF4 pathway-mediated cyclooxygenase-2 induction regulates cadmium-induced autophagy in kidney
Q53746165Highlight report: acetaminophen hepatotoxicity.
Q46631624Highlight report: xenobiotic-metabolizing enzymes in skin models
Q35907145Inhibition of Prostaglandin Reductase 2, a Putative Oncogene Overexpressed in Human Pancreatic Adenocarcinoma, Induces Oxidative Stress-Mediated Cell Death Involving xCT and CTH Gene Expressions through 15-Keto-PGE2
Q38711430Initial autophagic protection switches to disruption of autophagic flux by lysosomal instability during cadmium stress accrual in renal NRK-52E cells.
Q42517219Live and Let Die: Roles of Autophagy in Cadmium Nephrotoxicity
Q99594768RSK2 protects human breast cancer cells under endoplasmic reticulum stress through activating AMPKα2-mediated autophagy
Q52152068Zinc regulates expression of IL-23 p19 mRNA via activation of eIF2α/ATF4 axis in HAPI cells.

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