Energetics, kinetics, and pathway of SNARE folding and assembly revealed by optical tweezers

scientific article published on 18 January 2017

Energetics, kinetics, and pathway of SNARE folding and assembly revealed by optical tweezers is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PRO.3116
P932PMC publication ID5477538
P698PubMed publication ID28097727

P2093author name stringYongli Zhang
P2860cites workModification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusionQ21563602
Mechanical unzipping and rezipping of a single SNARE complex reveals hysteresis as a force-generating mechanismQ22061733
Direct observation of base-pair stepping by RNA polymeraseQ24540192
Differential detection of dual traps improves the spatial resolution of optical tweezersQ24548494
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitroQ24629968
Membrane fusion: grappling with SNARE and SM proteinsQ24633113
Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREsQ24656954
Neurotransmitter release: the last millisecond in the life of a synaptic vesicleQ26269845
Lipid-anchored SNAREs lacking transmembrane regions fully support membrane fusion during neurotransmitter releaseQ26269847
SNARE zipperingQ26751424
Molecular machines governing exocytosis of synaptic vesiclesQ26849286
A Chemical Controller of SNARE-Driven Membrane Fusion That Primes Vesicles for Ca(2+)-Triggered Millisecond ExocytosisQ27336160
Helical extension of the neuronal SNARE complex into the membraneQ27646399
Dynamic structure of lipid-bound synaptobrevin suggests a nucleation-propagation mechanism for trans-SNARE complex formationQ27658206
A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutantsQ27731470
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolutionQ27765619
SNAP receptors implicated in vesicle targeting and fusionQ28131653
SNAREpins: minimal machinery for membrane fusionQ28131697
Mechanical processes in biochemistryQ28266209
Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopyQ28581498
Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusionQ28584744
SNAREs--engines for membrane fusionQ29547230
Stretching DNAQ30040484
High-resolution optical tweezers for single-molecule manipulationQ30449157
Multiple intermediates in SNARE-induced membrane fusionQ30478481
In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter releaseQ30502775
Interactions between synaptic vesicle fusion proteins explored by atomic force microscopyQ30960921
Single-molecule studies of SNARE complex assembly reveal parallel and antiparallel configurationsQ31031114
Single molecule mechanical probing of the SNARE protein interactionsQ33241577
Interference model for back-focal-plane displacement detection in optical tweezers.Q33310600
Pulling force generated by interacting SNAREs facilitates membrane hemifusion.Q33519916
Single Molecule Measurements of Interaction Free Energies Between the Proteins Within Binary and Ternary SNARE ComplexesQ33526994
Purification of an N-ethylmaleimide-sensitive protein catalyzing vesicular transportQ33658648
How could SNARE proteins open a fusion pore?Q33918609
Common intermediates and kinetics, but different energetics, in the assembly of SNARE proteinsQ34196813
Role of the synaptobrevin C terminus in fusion pore formationQ34276398
Single reconstituted neuronal SNARE complexes zipper in three distinct stagesQ34294781
Transmembrane segments of syntaxin line the fusion pore of Ca2+-triggered exocytosis.Q34305380
The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged?Q34305507
Timing of neurotransmission at fast synapses in the mammalian brainQ34406384
Direct observation of the three-state folding of a single protein moleculeQ34453219
Nanomechanical measurements of the sequence-dependent folding landscapes of single nucleic acid hairpinsQ34597333
Mutant SNAP25B causes myasthenia, cortical hyperexcitability, ataxia, and intellectual disabilityQ34777891
Three αSNAP and 10 ATP molecules are used in SNARE complex disassembly by N-ethylmaleimide-sensitive factor (NSF)Q35002875
The RSC chromatin remodelling ATPase translocates DNA with high force and small step sizeQ35048885
Mechanistic insights into the recycling machine of the SNARE complexQ35058666
A mutation in the Golgi Qb-SNARE gene GOSR2 causes progressive myoclonus epilepsy with early ataxiaQ35136950
Multiple conformations of a single SNAREpin between two nanodisc membranes reveal diverse pre-fusion statesQ35532161
Spring-loaded unraveling of a single SNARE complex by NSF in one round of ATP turnoverQ35636093
Kinetically coupled folding of a single HIV-1 glycoprotein 41 complex in viral membrane fusion and inhibitionQ35699218
Single-molecule observation of helix staggering, sliding, and coiled coil misfoldingQ35889460
Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular CrowdingQ36263474
Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpinsQ36323855
v-SNARE transmembrane domains function as catalysts for vesicle fusionQ42382355
One SNARE complex is sufficient for membrane fusionQ42531466
Phase transition behavior of single phosphatidylcholine bilayers on a solid spherical support studied by DSC, NMR and FT-IRQ42582995
Reversible unfolding of single RNA molecules by mechanical forceQ43590684
SNARE assembly and disassembly exhibit a pronounced hysteresisQ43851628
A transient N-terminal interaction of SNAP-25 and syntaxin nucleates SNARE assemblyQ44686474
Role of an N-ethylmaleimide-sensitive transport component in promoting fusion of transport vesicles with cisternae of the Golgi stackQ46341560
On the value of c: can low affinity systems be studied by isothermal titration calorimetry?Q47357121
The principle of membrane fusion in the cell (Nobel lecture).Q48069250
Fast vesicle fusion in living cells requires at least three SNARE complexes.Q50541149
Direct observation of transition paths during the folding of proteins and nucleic acids.Q53112464
Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor ComplexesQ56992446
DNA-Induced Programmable Fusion of Phospholipid VesiclesQ57365828
Inhibition of SNARE Complex Assembly Differentially Affects Kinetic Components of ExocytosisQ57978998
v-SNARE Actions during Ca2+-Triggered ExocytosisQ58343442
N- to C-Terminal SNARE Complex Assembly Promotes Rapid Membrane FusionQ63610158
Activity-dependent changes in partial VAMP complexes during neurotransmitter releaseQ73202435
Energetics and dynamics of SNAREpin folding across lipid bilayersQ81376037
Membrane-proximal tryptophans of synaptobrevin II stabilize priming of secretory vesiclesQ85392206
Membrane interactions of fusogenic coiled-coil peptides: implications for lipopeptide mediated vesicle fusionQ88050467
Protein-DNA chimeras for single molecule mechanical folding studies with the optical tweezersQ40311799
α-SNAP interferes with the zippering of the SNARE protein membrane fusion machineryQ40370953
Exocytosis requires asymmetry in the central layer of the SNARE complexQ40388114
α-SNAP Enhances SNARE Zippering by Stabilizing the SNARE Four-Helix Bundle.Q40408922
Neurotransmitter release - four years of SNARE complexesQ41541527
A conserved membrane attachment site in alpha-SNAP facilitates N-ethylmaleimide-sensitive factor (NSF)-driven SNARE complex disassembly.Q41868502
SNARE proteins: one to fuse and three to keep the nascent fusion pore openQ41920045
Is assembly of the SNARE complex enough to fuel membrane fusion?Q42059651
Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosisQ42176873
A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assemblyQ42288650
Structure and function of SNARE and SNARE-interacting proteinsQ36335459
Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchorsQ36342484
The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosisQ36344941
Synaptic proteins promote calcium-triggered fast transition from point contact to full fusionQ36446947
Structure-Based Derivation of Protein Folding Intermediates and Energies from Optical TweezersQ36495463
Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion.Q36548383
Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosisQ36552655
Exocytotic fusion pores are composed of both lipids and proteinsQ36589148
Calculating Transition Energy Barriers and Characterizing Activation States for Steps of FusionQ36678687
Snapshot of sequential SNARE assembling states between membranes shows that N-terminal transient assembly initializes fusionQ36770797
Overstretching B-DNA: the elastic response of individual double-stranded and single-stranded DNA moleculesQ36798786
Highly anisotropic stability and folding kinetics of a single coiled coil protein under mechanical tensionQ36897066
Membrane fusion intermediates via directional and full assembly of the SNARE complexQ36916260
Nanodisc-cell fusion: control of fusion pore nucleation and lifetimes by SNARE protein transmembrane domainsQ36970468
Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complexQ37052763
Effects of linker sequences on vesicle fusion mediated by lipid-anchored DNA oligonucleotidesQ37079079
Recent advances in optical tweezersQ37096963
Molecular form follows function: (un)snaring the SNAREsQ37233520
Capture and release of partially zipped trans-SNARE complexes on intact organellesQ37237653
Kinetic barriers to SNAREpin assembly in the regulation of membrane docking/priming and fusion.Q37281549
Complexin-1 enhances the on-rate of vesicle docking via simultaneous SNARE and membrane interactionsQ37370388
Stability, folding dynamics, and long-range conformational transition of the synaptic t-SNARE complexQ37514982
Conflicting views on the membrane fusion machinery and the fusion poreQ37540115
A half-zippered SNARE complex represents a functional intermediate in membrane fusion.Q37701673
Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter releaseQ38166028
The molecular machinery of neurotransmitter release (Nobel lecture).Q38262070
Control of membrane gaps by synaptotagmin-Ca2+ measured with a novel membrane distance rulerQ38302250
SNARE complex formation is triggered by Ca2+ and drives membrane fusionQ38325384
SNARE protein analog-mediated membrane fusion.Q38413709
SNARE and regulatory proteins induce local membrane protrusions to prime docked vesicles for fast calcium-triggered fusion.Q38798689
Chaperoning SNARE assembly and disassemblyQ38865222
Hidden Markov Modeling with Detailed Balance and Its Application to Single Protein FoldingQ39183266
Single-Molecule Protein Folding Experiments Using High-Precision Optical TweezersQ39187447
Extension of Helix 12 in Munc18-1 Induces Vesicle Priming.Q39643764
P433issue7
P921main subjectoptical tweezersQ1066633
P304page(s)1252-1265
P577publication date2017-03-08
P1433published inProtein ScienceQ7251445
P1476titleEnergetics, kinetics, and pathway of SNARE folding and assembly revealed by optical tweezers
P478volume26

Reverse relations

cites work (P2860)
Q47210280Editorial Overview: Single-Molecule Approaches up to Difficult Challenges in Folding and Dynamics
Q41540634Integrated Method to Attach DNA Handles and Functionally Select Proteins to Study Folding and Protein-Ligand Interactions with Optical Tweezers
Q92725689Mutations in the Neuronal Vesicular SNARE VAMP2 Affect Synaptic Membrane Fusion and Impair Human Neurodevelopment
Q61806540SNARE machinery is optimized for ultrafast fusion
Q57454615Single-Molecule Optical Tweezers Study of Regulated SNARE Assembly
Q56876830Switching of the folding-energy landscape governs the allosteric activation of protein kinase A
Q64229653Symmetrical organization of proteins under docked synaptic vesicles
Q60951140The Complex Conformational Dynamics of Neuronal Calcium Sensor-1: A Single Molecule Perspective
Q47423503Two Disease-Causing SNAP-25B Mutations Selectively Impair SNARE C-terminal Assembly