EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity

scientific article published on 21 August 2013

EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-13-0044
P8608Fatcat IDrelease_fazelsf4pjhdthot5i64zdpesq
P932PMC publication ID3823187
P698PubMed publication ID23966292
P5875ResearchGate publication ID256076386

P50authorLecia V SequistQ90926732
Patricia GreningerQ91735291
P2093author name stringJeffrey Settleman
Meng Wang
Lee Zou
Liliana Gheorghiu
Cyril H Benes
Henning Willers
Kerstin Borgmann
Heike N Pfäffle
Natalie Ferraiolo
P2860cites workIdentification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2Q24337575
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repairQ24337655
EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatmentQ24338426
Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repairQ25257863
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategyQ27860519
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinomaQ27860881
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymeraseQ28131711
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathwayQ28203777
Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insightsQ28252640
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathwaysQ28274882
Systematic identification of genomic markers of drug sensitivity in cancer cellsQ29547695
Fanconi anemia pathway heterogeneity revealed by cisplatin and oxaliplatin treatmentsQ33520771
Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapyQ33598694
DNA interstrand crosslink repair in mammalian cells: step by stepQ33669915
Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repairQ33762568
FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link RepairQ34128701
New driver mutations in non-small-cell lung cancerQ34161395
Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathwayQ34285356
Trapping of PARP1 and PARP2 by Clinical PARP InhibitorsQ34309488
BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.Q34449830
Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsiesQ34550979
An oncogene-induced DNA damage model for cancer developmentQ34759268
Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathwayQ34835796
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutatedQ35741383
Randomized phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB 30406 trialQ36097426
DNA interstrand crosslink repair and cancerQ36576047
Erlotinib attenuates homologous recombinational repair of chromosomal breaks in human breast cancer cellsQ36982835
First-line use of EGFR tyrosine kinase inhibitors in patients with NSCLC containing EGFR mutations.Q37729803
FANCP/SLX4: a Swiss army knife of DNA interstrand crosslink repairQ37870047
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EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaksQ38609721
In tumor cells regulation of DNA double strand break repair through EGF receptor involves both NHEJ and HR and is independent of p53 and K-Ras statusQ39526236
FANCD2 but not FANCA promotes cellular resistance to type II topoisomerase poisonsQ39574588
The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-linksQ39807128
AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51.Q39916383
Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinomaQ40124686
Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinaseQ40401323
Mutant rodent cell lines sensitive to ultraviolet light, ionizing radiation and cross-linking agents: a comprehensive survey of genetic and biochemical characteristicsQ40484333
Mechanism of RAD51-dependent DNA interstrand cross-link repair.Q41070024
Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotypeQ42481495
Detection of impaired homologous recombination repair in NSCLC cells and tissues.Q43246772
Association of epidermal growth factor receptor activating mutations with low ERCC1 gene expression in non-small cell lung cancerQ46225965
Cisplatin-mediated DNA double-strand breaks in replicating but not in quiescent cells of the yeast Saccharomyces cerevisiaeQ46540743
Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinibQ46618741
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibitionQ64388338
The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatinQ64388522
Allele-dependent variation in the relative cellular potency of distinct EGFR inhibitorsQ80315104
EGFR mutant lung adenocarcinomas in patients with germline BRCA mutationsQ81562470
P433issue20
P407language of work or nameEnglishQ1860
P921main subjectphenotypeQ104053
P304page(s)6254-6263
P577publication date2013-08-21
P1433published inCancer ResearchQ326097
P1476titleEGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity
P478volume73

Reverse relations

cites work (P2860)
Q92877857Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity
Q36073749DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity
Q39846614Disruption of SLX4-MUS81 Function Increases the Relative Biological Effectiveness of Proton Radiation
Q42513590EGFR Mutations Compromise Hypoxia-Associated Radiation Resistance through Impaired Replication Fork-Associated DNA Damage Repair
Q92241385EGFR exon 19-deletion aberrantly regulate ERCC1 expression that may partly impaired DNA damage repair ability in non-small cell lung cancer
Q26768267Enhancing tumor-targeting monoclonal antibodies therapy by PARP inhibitors
Q41964099Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells
Q92027154Induction of Acquired Resistance towards EGFR Inhibitor Gefitinib in a Patient-Derived Xenograft Model of Non-Small Cell Lung Cancer and Subsequent Molecular Characterization
Q64087613Metformin reverses PARP inhibitors-induced epithelial-mesenchymal transition and PD-L1 upregulation in triple-negative breast cancer
Q40456709Minocycline Improves the Efficacy of EGFR Inhibitor Therapy: A Hypothesis.
Q28540769Preclinical assessment of carboplatin treatment efficacy in lung cancer by 18F-ICMT-11-positron emission tomography
Q64988279Prospect for Application of PARP Inhibitor in Patients with HER2 Negative Breast Cancer.
Q103826099Role of PARP1-mediated autophagy in EGFR-TKI resistance in non-small cell lung cancer
Q34453444Structural insights into 5' flap DNA unwinding and incision by the human FAN1 dimer
Q89861185Synergistic Anti-Tumour Effect of Syk Inhibitor and Olaparib in Squamous Cell Carcinoma: Roles of Syk in EGFR Signalling and PARP1 Activation

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