Induction of Acquired Resistance towards EGFR Inhibitor Gefitinib in a Patient-Derived Xenograft Model of Non-Small Cell Lung Cancer and Subsequent Molecular Characterization

scientific article published on 18 July 2019

Induction of Acquired Resistance towards EGFR Inhibitor Gefitinib in a Patient-Derived Xenograft Model of Non-Small Cell Lung Cancer and Subsequent Molecular Characterization is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/CELLS8070740
P932PMC publication ID6678194
P698PubMed publication ID31323891

P50authorLeanne de KoningQ92027149
P2093author name stringWolfgang Sommergruber
Cordula Tschuch
Anne-Lise Peille
Julia Schueler
Kerstin Klingner
Eva Oswald
Daniel Bug
Hagen Klett
P2860cites workHER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitorsQ24297102
AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomasQ24336818
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A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma.Q46093038
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Next-generation sequencing reveals novel resistance mechanisms and molecular heterogeneity in EGFR-mutant non-small cell lung cancer with acquired resistance to EGFR-TKIsQ47374429
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Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistanceQ33977056
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EGFR inhibition evokes innate drug resistance in lung cancer cells by preventing Akt activity and thus inactivating Ets-1 functionQ35895556
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STAT1 Activation Is Enhanced by Cisplatin and Variably Affected by EGFR Inhibition in HNSCC CellsQ36030906
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STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3Q36351195
An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistanceQ36597042
Tumor models for efficacy determinationQ36623519
Epidermal growth factor receptor tyrosine kinase inhibitor-resistant diseaseQ36660669
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Prognostic value of a newly identified MALAT1 alternatively spliced transcript in breast cancerQ37174025
The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial-mesenchymal transitionQ37306549
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IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancerQ37532498
ERK1/2 blockade prevents epithelial-mesenchymal transition in lung cancer cells and promotes their sensitivity to EGFR inhibitionQ37661108
Next-generation sequencing of non-small cell lung cancer using a customized, targeted sequencing panel: Emphasis on small biopsy and cytologyQ37736978
The tumor stroma as mediator of drug resistance--a potential target to improve cancer therapy?Q37878534
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P921main subjectnon-small-cell lung carcinomaQ3658562
P577publication date2019-07-18
P1433published inCellsQ27724621
P1476titleInduction of Acquired Resistance towards EGFR Inhibitor Gefitinib in a Patient-Derived Xenograft Model of Non-Small Cell Lung Cancer and Subsequent Molecular Characterization
P478volume8

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cites work (P2860)
Q98188949Genipin suppression of growth and metastasis in hepatocellular carcinoma through blocking activation of STAT-3
Q92678621Sodium cantharidate targets STAT3 and abrogates EGFR inhibitor resistance in osteosarcoma
Q93173743Triptolide inhibits epithelial‑mesenchymal transition and induces apoptosis in gefitinib‑resistant lung cancer cells

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