EBV-encoded LMP-1 sensitizes nasopharyngeal carcinoma cells to genotoxic drugs by down-regulating Cabin1 expression

scientific article published on March 2014

EBV-encoded LMP-1 sensitizes nasopharyngeal carcinoma cells to genotoxic drugs by down-regulating Cabin1 expression is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/JCP.24448
P698PubMed publication ID23939952

P2093author name stringChuck C-K Chao
Pu-Yuan Chang
Nian-Kang Sun
Zchong-Zcho Wu
P2860cites workElk-1 a transcription factor with multiple facets in the brainQ21129371
Cabin 1, a negative regulator for calcineurin signaling in T lymphocytesQ24313056
Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosisQ24599847
Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cellsQ24674634
The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosisQ28142953
Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2Q28146018
The complexity of p53 modulation: emerging patterns from divergent signalsQ28284854
The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor familyQ28307399
Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophyQ28343890
Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell deathQ28564504
Cain, a novel physiologic protein inhibitor of calcineurinQ28570296
Two-site interaction of nuclear factor of activated T cells with activated calcineurinQ28616392
Cofactor dynamics and sufficiency in estrogen receptor-regulated transcriptionQ29547846
Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteinsQ33891012
eIF-4E expression and its role in malignancies and metastases.Q35750118
Calcineurin activity is required for the initiation of skeletal muscle differentiationQ36327575
Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformationQ36575274
Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stressQ36619894
Living with p53, dying of p53.Q36919156
Targeting the eukaryotic translation initiation factor 4E for cancer therapyQ37075670
Cross-resistance to death ligand-induced apoptosis in cisplatin-selected HeLa cells associated with overexpression of DDB2 and subsequent induction of cFLIP.Q38332168
Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulationQ39477209
Knockdown of CITED2 using short-hairpin RNA sensitizes cancer cells to cisplatin through stabilization of p53 and enhancement of p53-dependent apoptosisQ39527015
Knockdown of NAPA using short-hairpin RNA sensitizes cancer cells to cisplatin: implications to overcome chemoresistanceQ39676804
Cabin1 restrains p53 activity on chromatin.Q39814358
Epstein-Barr virus-encoded latent membrane protein 1 promotes stress-induced apoptosis upstream of caspase-2-dependent mitochondrial perturbationQ40509666
Epstein-Barr virus latent membrane protein 1 induces micronucleus formation, represses DNA repair and enhances sensitivity to DNA-damaging agents in human epithelial cells.Q40600441
Apoptosis modulation of Epstein-Barr virus-encoded latent membrane protein 1 in the epithelial cell line HeLa is stimulus-dependentQ40680566
Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodelingQ40687983
Apaf-1 overexpression partially overcomes apoptotic resistance in a cisplatin-selected HeLa cell lineQ40779227
The Epstein-Barr virus latent membrane protein 1 (LMP1) enhances TNF alpha-induced apoptosis of intestine 407 epithelial cells: the role of LMP1 C-terminal activation regions 1 and 2.Q40882594
Activation of a ras-MAPK-dependent pathway by Epstein-Barr virus latent membrane protein 1 is essential for cellular transformationQ41068635
Epstein-Barr virus latent membrane protein inhibits human epithelial cell differentiationQ41736955
Amino-terminal-derived JNK fragment alters expression and activity of c-Jun, ATF2, and p53 and increases H2O2-induced cell deathQ42803661
Latent membrane protein 1 of Epstein-Barr virus sensitizes cancer cells to cisplatin by enhancing NF-κB p50 homodimer formation and downregulating NAPA expression.Q42805210
Three distinct signalling responses by murine fibroblasts to genotoxic stressQ42807014
Identification and functional analysis of genes which confer resistance to cisplatin in tumor cellsQ43110995
Cisplatin induction of ERCC-1 mRNA expression in A2780/CP70 human ovarian cancer cells.Q52184954
An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells.Q53541156
Three paths to stress reliefQ59054090
P433issue3
P921main subjectgenotoxicityQ1009245
P304page(s)309-322
P577publication date2014-03-01
P1433published inJournal of Cellular PhysiologyQ1524270
P1476titleEBV-encoded LMP-1 sensitizes nasopharyngeal carcinoma cells to genotoxic drugs by down-regulating Cabin1 expression
P478volume229

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cites work (P2860)
Q35032548Epstein-Barr Virus_Encoded LMP1 upregulates microRNA-21 to promote the resistance of nasopharyngeal carcinoma cells to cisplatin-induced Apoptosis by suppressing PDCD4 and Fas-L.
Q38633665JNK pathway inhibition enhances chemotherapeutic sensitivity to Adriamycin in nasopharyngeal carcinoma cells
Q35990061Novel Biomarker Proteins in Chronic Lymphocytic Leukemia: Impact on Diagnosis, Prognosis and Treatment
Q90687242iTRAQ-based quantitative proteomic analysis of differentially expressed proteins in chemoresistant nasopharyngeal carcinoma