Elk-1 a transcription factor with multiple facets in the brain

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Elk-1 a transcription factor with multiple facets in the brain is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FNINS.2011.00035
P932PMC publication ID3060702
P698PubMed publication ID21441990
P5875ResearchGate publication ID50868428

P50authorAntoine BesnardQ57699032
Jocelyne CabocheQ114416335
P2093author name stringPeter Vanhoutte
Beatriz Galan-Rodriguez
P2860cites workEts transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoterQ24301891
MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14Q24303450
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREBQ24319704
Net, a new ets transcription factor that is activated by RasQ24336684
Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response elementQ24337763
MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300.Q24540319
Spatial flexibility in ternary complexes between SRF and its accessory proteinsQ24555659
Activation of ternary complex factor Elk-1 by MAP kinasesQ24564310
Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)Q24568248
SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1Q24676460
MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cellsQ28140410
Opposing roles of Elk-1 and its brain-specific isoform, short Elk-1, in nerve growth factor-induced PC12 differentiationQ28142139
Mammalian Srb/Mediator complex is targeted by adenovirus E1A proteinQ28198008
Functional dissection of the transcription factor Elk-1Q28250819
c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factorsQ28257088
Long-term depression activates transcription of immediate early transcription factor genes: involvement of serum response factor/Elk-1.Q48449191
Region-directed phototransfection reveals the functional significance of a dendritically synthesized transcription factorQ48524690
Long-term depression in the adult hippocampus in vivo involves activation of extracellular signal-regulated kinase and phosphorylation of Elk-1.Q48661247
A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memoriesQ48971377
Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties.Q51423988
Comparative analysis of the activation of the Elk-1 transcription factor in the central nervous system of animals with different learning capacities.Q52086211
Predicting pathway perturbations in Down syndrome.Q52090826
Integration of MAP kinase signal transduction pathways at the serum response elementQ58415341
Molecular mechanisms of drug addictionQ59410663
Dynamic Interplay of the SUMO and ERK Pathways in Regulating Elk-1 Transcriptional ActivityQ60304925
Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3–CA1 synapsesQ61640741
The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoterQ69177591
Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fos production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockadeQ73553336
Chromatin structure analysis of the human c-fos promoter reveals a centrally positioned nucleosomeQ73698364
Molecular phylogeny of the ETS gene familyQ74450239
Interaction of transcription factors with serum response factor. Identification of the Elk-1 binding surfaceQ74465577
The ETS-domain transcription factor familyQ77199453
In vivo expression and regulation of Elk-1, a target of the extracellular-regulated kinase signaling pathway, in the adult rat brainQ28257720
Delta elk-1, a variant of elk-1, fails to interact with the serum response factor and binds to DNA with modulated specificityQ28265166
Activation of ternary complex factor Elk-1 by stress-activated protein kinasesQ28272395
Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCFQ28283139
Elk-1 associates with the mitochondrial permeability transition pore complex in neuronsQ28568322
Rapid phosphorylation of Elk-1 transcription factor and activation of MAP kinase signal transduction pathways in response to visual stimulationQ28576547
Sequestration of serum response factor in the hippocampus impairs long-term spatial memoryQ28579819
Phosphorylation of hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during contextual fear conditioning: interactions between Erk-1/2 and Elk-1Q28609343
Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos geneQ28609839
Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6Q28678886
In vivo protein transduction: delivery of a biologically active protein into the mouseQ29615482
MAPK cascade signalling and synaptic plasticityQ29619955
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domainQ29620270
Role of the ERK pathway in psychostimulant-induced locomotor sensitization.Q33235276
A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseasesQ33528960
Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatumQ33723743
Glutamate induces phosphorylation of Elk-1 and CREB, along with c-fos activation, via an extracellular signal-regulated kinase-dependent pathway in brain slicesQ33957030
Docking domains and substrate-specificity determination for MAP kinasesQ34023280
Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activationQ34308397
Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomesQ34372766
Regulation of cocaine reward by CREB.Q34483870
Mitogen-activated protein kinase/extracellular signal-regulated kinase induced gene regulation in brain: a molecular substrate for learning and memory?Q34510407
elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpointsQ34666320
The calcium/calmodulin-dependent protein phosphatase calcineurin is the major Elk-1 phosphataseQ34743578
Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinaseQ35186927
Mitogen-activated protein kinases in synaptic plasticity and memory.Q35803116
Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene familyQ35917053
Transcriptional dysregulation in Down syndrome: predictions for altered protein complex stoichiometries and post-translational modifications, and consequences for learning/behavior genes ELK, CREB, and the estrogen and glucocorticoid receptorsQ36406679
Role of ERK in cocaine addiction.Q36644835
ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte developmentQ36652758
Functional versatility of transcription factors in the nervous system: the SRF paradigmQ37566994
Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factorsQ37592367
Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.Q37625844
Coordinated control of the gene expression machineryQ37728264
Heterogeneity of ternary complex factors in HeLa cell nuclear extracts.Q38304330
Mitogen-induced recruitment of ERK and MSK to SRE promoter complexes by ternary complex factor Elk-1.Q38315112
PIASx acts as an Elk-1 coactivator by facilitating derepressionQ39366507
Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1.Q39458882
Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylationQ39631004
The ETS domain transcription factor Elk-1 contains a novel class of repression domainQ39695530
Overlapping promoter targeting by Elk-1 and other divergent ETS-domain transcription factor family membersQ39793598
Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machineryQ39811506
Regulation of ERK1/2 phosphorylation by acute and chronic morphine - implications for the role of cAMP-responsive element binding factor (CREB)-dependent and Ets-like protein-1 (Elk-1)-dependent transcription; small interfering RNA-based strategyQ39963045
Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation.Q40034016
PIASxalpha differentially regulates the amplitudes of transcriptional responses following activation of the ERK and p38 MAPK pathwaysQ40277497
Mice deficient for the ets transcription factor elk-1 show normal immune responses and mildly impaired neuronal gene activationQ40376816
The ETS domain transcription factor Elk-1 regulates the expression of its partner protein, SRF.Q40494681
alpha-Synuclein forms a complex with transcription factor Elk-1.Q40816103
MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP.Q41150603
Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoterQ41612990
Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinases is negatively regulated by protein phosphatase 2B (calcineurin).Q41665357
MAP kinase-mediated c-fos regulation relies on a histone acetylation relay switchQ41834867
The mechanism of phosphorylation-inducible activation of the ETS-domain transcription factor Elk-1.Q42005729
Effects of acute cocaine on ERK and DARPP-32 phosphorylation pathways in the caudate-putamen of Fischer ratsQ42369179
The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo.Q42488934
Molecular cloning of Elk-3, a new member of the Ets family expressed during mouse embryogenesis and analysis of its transcriptional repression activityQ42526217
ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometryQ42806499
Functional analysis of a growth factor-responsive transcription factor complexQ42810320
Induction-independent recruitment of CREB-binding protein to the c-fos serum response element through interactions between the bromodomain and Elk-1.Q42834097
Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjectsQ43594315
Docking sites on substrate proteins direct extracellular signal-regulated kinase to phosphorylate specific residuesQ43616462
Delta 9-tetrahydrocannabinol-induced MAPK/ERK and Elk-1 activation in vivo depends on dopaminergic transmission.Q43734938
Amphetamine increases phosphorylation of extracellular signal-regulated kinase and transcription factors in the rat striatum via group I metabotropic glutamate receptorsQ44177810
Modulation of taste-induced Elk-1 activation by identified neurotransmitter systems in the insular cortex of the behaving rat.Q44249636
Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor inductionQ44712085
Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons.Q44752355
Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain.Q44840053
Regulations of methamphetamine reward by extracellular signal-regulated kinase 1/2/ets-like gene-1 signaling pathway via the activation of dopamine receptorsQ44854959
Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death.Q45307003
Endocytosis controls glutamate-induced nuclear accumulation of ERK.Q45364300
Molecular substrates for retrieval and reconsolidation of cocaine-associated contextual memoryQ46269232
Elk-1 interacts with neuronal microtubules and relocalizes to the nucleus upon phosphorylationQ46712826
Effector immediate-early gene arc in the amygdala plays a critical role in alcoholismQ46717130
Cocaine induction of ERK proteins in dorsal striatum of Fischer rats.Q46792014
A TAT-DEF-Elk-1 peptide regulates the cytonuclear trafficking of Elk-1 and controls cytoskeleton dynamics.Q46832190
Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice.Q46843660
Serum response factor controls neuronal circuit assembly in the hippocampusQ46896180
SUMO promotes HDAC-mediated transcriptional repressionQ48017954
Differential effects of acute and chronic nicotine on Elk-1 in rat hippocampus.Q48272228
DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylationQ48300617
Specific and differential activation of mitogen-activated protein kinase cascades by unfamiliar taste in the insular cortex of the behaving rat.Q48346507
Extracellular signal-regulated kinase (ERK) controls immediate early gene induction on corticostriatal stimulation.Q48367956
P407language of work or nameEnglishQ1860
P921main subjectbrainQ1073
P304page(s)35
P577publication date2011-01-01
P1433published inFrontiers in NeuroscienceQ2177807
P1476titleElk-1 a transcription factor with multiple facets in the brain
P478volume5

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