Indoxyl Sulfate: A Novel Cardiovascular Risk Factor in Chronic Kidney Disease.

scientific article published on 7 February 2017

Indoxyl Sulfate: A Novel Cardiovascular Risk Factor in Chronic Kidney Disease. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1161/JAHA.116.005022
P932PMC publication ID5523780
P698PubMed publication ID28174171

P50authorChih-Cheng WuQ57016334
P2093author name stringDer-Cherng Tarng
Szu-Chun Hung
Ko-Lin Kuo
P2860cites workThe aryl hydrocarbon receptor-activating effect of uremic toxins from tryptophan metabolism: a new concept to understand cardiovascular complications of chronic kidney diseaseQ28382992
Indoxyl Sulfate Induces Leukocyte-Endothelial Interactions through Up-regulation of E-selectinQ30497600
Chronic kidney disease-induced cardiac fibrosis is ameliorated by reducing circulating levels of a non-dialysable uremic toxin, indoxyl sulfateQ31076633
Subtotal nephrectomy impairs ischemia-induced angiogenesis and hindlimb re-perfusion in ratsQ33241242
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Cardiovascular disease relates to intestinal uptake of p-cresol in patients with chronic kidney diseaseQ33780255
Impact of aortic stiffness on survival in end-stage renal diseaseQ33861423
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The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic reviewQ34103477
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Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and PreventiQ34272627
Indoxyl Sulfate–Induced Endothelial Dysfunction in Patients with Chronic Kidney Disease via an Induction of Oxidative StressQ34497254
p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney diseaseQ34593224
Association of indoxyl sulfate with heart failure among patients on hemodialysisQ34828638
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The cardiovascular effect of the uremic solute indole-3 acetic acidQ35228517
Uremic retention solute indoxyl sulfate level is associated with prolonged QTc interval in early CKD patientsQ35495467
Uremic serum and solutes increase post-vascular interventional thrombotic risk through altered stability of smooth muscle cell tissue factorQ35532690
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Microbiota-Derived Phenylacetylglutamine Associates with Overall Mortality and Cardiovascular Disease in Patients with CKD.Q36031714
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Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis BurdenQ36417895
Serum Indoxyl Sulfate Associates with Postangioplasty Thrombosis of Dialysis GraftsQ36746081
Role of Indoxyl Sulfate as a Predisposing Factor for Atrial Fibrillation in Renal DysfunctionQ36836055
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Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patientsQ37378435
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Normal and pathologic concentrations of uremic toxinsQ38012908
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Protein-bound uremic toxins: a long overlooked culprit in cardiorenal syndromeQ38826236
The harmful effect of indoxyl sulfate on neovascularization in chronic kidney diseaseQ39994491
Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migrationQ40866639
Dialysis Vascular Access Intervention and the Search for BiomarkersQ42925625
Serum protein-bound uraemic toxins and clinical outcomes in haemodialysis patientsQ43064207
Indoxyl sulfate upregulates expression of ICAM-1 and MCP-1 by oxidative stress-induced NF-kappaB activation.Q43100843
Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes?Q43202700
Free p-cresylsulphate is a predictor of mortality in patients at different stages of chronic kidney diseaseQ43241952
Association between AST-120 and abdominal aortic calcification in predialysis patients with chronic kidney diseaseQ43461034
Oral charcoal adsorbent (AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stressQ43609975
Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failureQ43803594
Traditional cardiovascular disease risk factors in dialysis patients compared with the general population: the CHOICE StudyQ44044868
Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathwayQ44141875
Bifidobacterium in gastro-resistant seamless capsule reduces serum levels of indoxyl sulfate in patients on hemodialysisQ44338020
Very low protein diet reduces indoxyl sulfate levels in chronic kidney diseaseQ44527821
The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repairQ44724729
Oral ADSORBENT AST-120 decreases carotid intima-media thickness and arterial stiffness in patients with chronic renal failureQ44820468
Chronic kidney disease alters intestinal microbial floraQ46042782
Indoxyl sulphate induces oxidative stress and the expression of osteoblast-specific proteins in vascular smooth muscle cells.Q46150965
Indoxyl sulfate inhibits nitric oxide production and cell viability by inducing oxidative stress in vascular endothelial cellsQ46171652
Indoxyl sulfate promotes proliferation of human aortic smooth muscle cells by inducing oxidative stress.Q46176151
All-cause mortality attributable to chronic kidney disease: a prospective cohort study based on 462 293 adults in TaiwanQ46513688
Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysisQ46610834
Free p-cresol is associated with cardiovascular disease in hemodialysis patientsQ46729408
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.Q46900369
Indoxyl sulfate predicts cardiovascular disease and renal function deterioration in advanced chronic kidney diseaseQ47274327
Indoxyl sulfate suppresses endothelial progenitor cell-mediated neovascularizationQ48063950
Kidney function and risk of peripheral arterial disease: results from the Atherosclerosis Risk in Communities (ARIC) Study.Q50795933
The uremic toxin indoxyl sulfate increases pulmonary vein and atrial arrhythmogenesis.Q53017670
Indoxyl sulfate stimulates proliferation of rat vascular smooth muscle cells.Q53627736
Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cellsQ58816342
Nontraumatic lower extremity amputations in the Medicare end-stage renal disease populationQ60484698
Accelerated atherosclerosis in prolonged maintenance hemodialysisQ69737869
Inhibition of the accumulation of uremic toxins in the blood and their precursors in the feces after oral administration of Lebenin, a lactic acid bacteria preparation, to uremic patients undergoing hemodialysisQ71728826
Rats with moderate renal failure show capillary deficit in heart but not skeletal muscleQ73686582
The protein metabolite hypothesis, a model for the progression of renal failure: an oral adsorbent lowers indoxyl sulfate levels in undialyzed uremic patientsQ73831646
Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive ratsQ80853636
A multicenter, randomized, double-blind, placebo-controlled, dose-ranging study of AST-120 (Kremezin) in patients with moderate to severe CKDQ82971657
Characteristics of sudden death in hemodialysis patientsQ83283477
Atrial fibrillation: the beat is faster than the answersQ83446442
Effects of AST-120 on left ventricular mass in predialysis patientsQ83448636
Serum free p-cresyl sulfate levels predict cardiovascular and all-cause mortality in elderly hemodialysis patients--a prospective cohort studyQ84888198
In acute kidney injury, indoxyl sulfate impairs human endothelial progenitor cells: modulation by statinQ86113659
P275copyright licenseCreative Commons Attribution-NonCommercialQ6936496
P433issue2
P921main subjectcardiovascular diseaseQ389735
chronic renal insufficiencyQ736715
risk factorQ1475848
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P577publication date2017-02-07
P1433published inJournal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseQ19880670
P1476titleIndoxyl Sulfate: A Novel Cardiovascular Risk Factor in Chronic Kidney Disease
P478volume6

Reverse relations

cites work (P2860)
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Q89397321Differences in peritoneal solute transport rates in peritoneal dialysis
Q89459610Echocardiography-based pressure-volume loop assessment in the evaluation for the effects of indoxyl sulfate on cardiovascular function
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Q92878090Indoxyl sulfate impairs valsartan-induced neovascularization
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Q52730786Phenyl sulfate, indoxyl sulfate and p-cresyl sulfate decrease glutathione level to render cells vulnerable to oxidative stress in renal tubular cells.
Q60922951Prognostic Utility of Indoxyl Sulfate for Patients with Acute Coronary Syndrome
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Q89799717[Gut-heart axis : How gut bacteria influence cardiovascular diseases]