Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach

scientific article published on March 2013

Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CHEMBIOL.2013.02.011
P932PMC publication ID3712830
P698PubMed publication ID23521799
P5875ResearchGate publication ID236073657

P50authorLisa HensleyQ4795006
John ConnorQ37368402
Claire Marie FiloneQ39189551
P2093author name stringFeng Ni
John K Snyder
G Guy Bushkin
Andrew Platt
Brian Honeyman
Erin N Hodges
Karla Boyd
Kyle Strom
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Mutations that confer resistance to mycophenolic acid and ribavirin on sindbis virus map to the nonstructural protein nsP1Q42986339
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Natural polymorphisms and resistance-associated mutations in the fusion protein of respiratory syncytial virus (RSV): effects on RSV susceptibility to palivizumabQ45360940
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Toxicity of antiretroviral nucleoside and nucleotide analogues: is mitochondrial toxicity the only mechanism?Q34122406
The mechanism of action of ribavirin: lethal mutagenesis of RNA virus genomes mediated by the viral RNA-dependent RNA polymeraseQ34608397
Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesisQ34805086
Potent inhibitors of hepatitis C core dimerization as new leads for anti-hepatitis C agentsQ34906082
Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agentQ35101611
Vesicular stomatitis viruses resistant to the methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylationQ35785366
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Host-directed drug targeting of factors hijacked by pathogensQ37224146
Preferential translation of vesicular stomatitis virus mRNAs is conferred by transcription from the viral genomeQ39320821
P433issue3
P921main subjectviral RNA synthesisQ115189418
P304page(s)424-433
P577publication date2013-03-01
P1433published inChemistry and BiologyQ15758410
P1476titleIdentification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach
P478volume20

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cites work (P2860)
Q37209733A novel Ebola virus expressing luciferase allows for rapid and quantitative testing of antivirals
Q50043318A polyamide inhibits replication of vesicular stomatitis virus by targeting RNA in the nucleocapsid.
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